Josh Saskin
he/him/his
About
Research
Publications
2026
Discovery and design of potent cell surface display elements
Fang Z, Saskin J, Lee SH, Zou C, Xin S, Huang X, Pan X, Dong C, Abiri A, Feng Y, Sahni N, Yi SS, Peng L, Chen S. Discovery and design of potent cell surface display elements. Nature Biotechnology 2026 DOI: 10.1038/s41587-026-03144-x.Peer-Reviewed Original ResearchOR7A10 GPCR engineering boosts CAR-NK therapy against solid tumours
Yang L, Renauer P, Tang K, Saskin J, Zhou L, Zou C, Lee S, Fox M, Johnson-Noya S, Weiss B, Deng S, Fang P, Chen B, Sferruzza G, Fooladi S, Zhao K, Park D, Zhang F, Tu J, Chen J, Moliterno J, Gunel M, Peng L, Chen S. OR7A10 GPCR engineering boosts CAR-NK therapy against solid tumours. Nature 2026, 652: 740-751. PMID: 41741641, DOI: 10.1038/s41586-026-10149-8.Peer-Reviewed Original ResearchThis study investigates OR7A10-engineered CAR-NK cells, showing they enhance tumor-killing ability, persistence, and survival in solid tumor models, offering a scalable cancer therapy.
2025
Hypothalamic opsin 3 suppresses MC4R signaling and potentiates Kir7.1 to promote food consumption
Haddad H, Mercado-Reyes J, Mustafá E, D’Souza S, Chung C, Nestor R, Olinski L, Damonte V, Saskin J, Vemaraju S, Raingo J, Kauer J, Lang R, Oancea E. Hypothalamic opsin 3 suppresses MC4R signaling and potentiates Kir7.1 to promote food consumption. Proceedings Of The National Academy Of Sciences Of The United States Of America 2025, 122: e2403891122. PMID: 39951488, PMCID: PMC11874419, DOI: 10.1073/pnas.2403891122.Peer-Reviewed Original Research
2024
Integrative functional genomic analyses identify genetic variants influencing skin pigmentation in Africans
Feng Y, Xie N, Inoue F, Fan S, Saskin J, Zhang C, Zhang F, Hansen M, Nyambo T, Mpoloka S, Mokone G, Fokunang C, Belay G, Njamnshi A, Marks M, Oancea E, Ahituv N, Tishkoff S. Integrative functional genomic analyses identify genetic variants influencing skin pigmentation in Africans. Nature Genetics 2024, 56: 258-272. PMID: 38200130, PMCID: PMC11005318, DOI: 10.1038/s41588-023-01626-1.Peer-Reviewed Original Research
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Sep 202628Monday
Yale Only Josh Saskin - Cara Ly