Yan Zhang
Research
Publications
2026
Insomnia and Incident Cardiovascular Disease in US Hispanic/Latino Adults: Results From HCHS/SOL.
Lü W, Wang Y, Wu S, Wang M, Huang J, Tang X, Zhang Y, Ren R. Insomnia and Incident Cardiovascular Disease in US Hispanic/Latino Adults: Results From HCHS/SOL. Journal Of The American Heart Association 2026, 15: e045593. PMID: 41717941, DOI: 10.1161/jaha.125.045593.Peer-Reviewed Original ResearchConceptsIncident cardiovascular diseaseUS Hispanic/Latino adultsHispanic/Latino adultsCardiovascular diseaseHazard of cardiovascular diseaseWomen's Health Initiative Insomnia Rating ScaleEarly morning awakeningRisk of incident cardiovascular diseaseHazard ratioAssociated with CVD riskInsomnia Rating ScaleCox proportional hazards modelsCardiovascular risk factorsProportional hazards modelMorning awakeningEffect modificationCVD riskSleep interventionsIndependent cardiovascular risk factorOlder individualsPrimary outcomeSleep durationLongitudinal evidenceRating Scale scoresHazards model
2025
Longitudinal symptom network analysis of perinatal depression in 5002 women: A dynamic perspective from pregnancy to postpartum
Peng Z, Wang M, Geng L, Meng Z, Zhang Y, Liu B, Liu J, Peng L, Peng Y, Qin X, Xiong J, Xu S, Zhang L, Liang H. Longitudinal symptom network analysis of perinatal depression in 5002 women: A dynamic perspective from pregnancy to postpartum. Journal Of Affective Disorders 2025, 397: 120974. PMID: 41422955, DOI: 10.1016/j.jad.2025.120974.Peer-Reviewed Original ResearchConceptsEdinburgh Postnatal Depression ScaleMultilevel mixed-effects modelsPerinatal depressive symptomsDepressive symptomsPerinatal depressionPostnatal Depression ScalePregnancy to postpartumLongitudinal studySelf-report questionnairesShenzhen Baoan WomeSpecific depressive symptomsDepression ScaleScreen-positive rateProportion of individualsClinical intervention strategiesHigher parityPostpartum periodSymptom pathwaysMixed-effects modelsEffective clinical intervention strategiesIntervention strategiesNon-completionOlder ageRisk factorsEmergence of anxietyAssociations of the triglyceride-glucose index and its combined indices with non-suicidal self-injury in adolescents with depressive disorders: the mediating role of sleep quality
Liu P, Gao S, Zhang Y, Li J, Du J, Yang N, Dong Q. Associations of the triglyceride-glucose index and its combined indices with non-suicidal self-injury in adolescents with depressive disorders: the mediating role of sleep quality. Frontiers In Psychiatry 2025, 16: 1689128. PMID: 41446291, PMCID: PMC12722861, DOI: 10.3389/fpsyt.2025.1689128.Peer-Reviewed Original ResearchNon-Suicidal Self-InjuryMajor depressive disorderDepressive disorderSelf-injurySleep qualityNon-suicidal self-injury groupAssociated with non-suicidal self-injuryDSM-5 criteriaNon-NSSI groupTyG indexIdentification of adolescentsDSM-5Combination indexHigher TyG index valuesMediation analysisTyG index valuesTriglyceride-glucose indexModerate predictive accuracyMultivariate logistic regressionAdolescentsFemale adolescentsAdjusted regression modelsTyG-WCSleepTriglyceride-glucoseForecasting the burden of insomnia: A call to action
Bao W, Ren R, Tang X, Zhang Y. Forecasting the burden of insomnia: A call to action. Sleep Medicine Reviews 2025, 84: 102211. PMID: 41313962, DOI: 10.1016/j.smrv.2025.102211.Peer-Reviewed Original ResearchPrevalence of obsessive‐compulsive disorder and related healthcare utilisation in China: a cross‐sectional epidemiological survey
Liu B, Cheng J, Liu Z, Huang Y, Rehman S, Shen M, Liu J, Ju Y, Yu Y, Xu X, Wang Z, Xu Y, Li T, Xu G, Xu X, Wang L, Yan Y, Xiao S, Zhang T, Yan J, Li L, Yin H, Zhang Y. Prevalence of obsessive‐compulsive disorder and related healthcare utilisation in China: a cross‐sectional epidemiological survey. General Psychiatry 2025, 38: e102013. PMID: 41246565, PMCID: PMC12612746, DOI: 10.1136/gpsych-2024-102013.Peer-Reviewed Original ResearchObsessive-compulsive disorderPopulation-based dataHealthcare utilisationComposite International Diagnostic Interview 3.0Disease surveillance pointsCross-sectional epidemiological surveyData of adultsArea probability sampleLifetime obsessive-compulsive disorderPrevalence of obsessive-compulsive disorderTrained interviewersSurveillance pointsWorld Health OrganizationMental disordersDisabling conditionDiagnostic InterviewProbability sampleRole impairmentMood disordersHealth OrganizationEpidemiological surveyEpidemiological dataHealthcareInterviewsResponse rateEfficacy and safety of perospirone as adjunctive therapy in major depressive disorder patients with inadequate response to antidepressants: a randomized clinical trial
Liu J, Gao S, Liu B, Ju Y, Liao M, Zhang L, Li Z, Zhang Q, Zhao X, Tang H, Jiang R, Zhou J, Yan D, Wang Z, Zheng Y, Cai D, Wei N, Zhang Y, Yu H, Ding L, Wang B, Liu G, Li K, Hu S, Yang F, Kuang L, Yao Z, Zhang Y, Li L. Efficacy and safety of perospirone as adjunctive therapy in major depressive disorder patients with inadequate response to antidepressants: a randomized clinical trial. EClinicalMedicine 2025, 90: 103626. PMID: 41497519, PMCID: PMC12766416, DOI: 10.1016/j.eclinm.2025.103626.Peer-Reviewed Original ResearchMajor depressive disorderInadequate response to antidepressantsMajor depressive disorder patientsSerotonin-norepinephrine reuptake inhibitorsResponse to antidepressantsSecond-generation antipsychoticsReuptake inhibitorsWeeks of antidepressant treatmentTotal scoreDiscontinuation rate due to adverse eventsScores of MADRSDepressive disorder patientsSerotonin reuptake inhibitorsNorepinephrine reuptake inhibitorsModerate-to-severe depressionTolerability of adjunctive therapyWeek 8Antidepressant treatmentExtrapyramidal symptomsSGA treatmentDepressive disorderAdjunctive therapyConfirmatory randomized controlled trialDisorder patientsAdverse eventsAssociations of Sleep-Disordered Breathing and Insomnia with Incident Metabolic Syndrome – The Hispanic Community Health Study/Study of Latinos
Wang Y, Lyu W, Feng X, Tang X, Zhang Y, Ren R. Associations of Sleep-Disordered Breathing and Insomnia with Incident Metabolic Syndrome – The Hispanic Community Health Study/Study of Latinos. Nature And Science Of Sleep 2025, 17: 2919-2931. PMID: 41245951, PMCID: PMC12619538, DOI: 10.2147/nss.s546410.Peer-Reviewed Original ResearchHispanic Community Health Study/StudyAssociated with incident MSSleep-disordered breathingIncident MSAssociation of sleep-disordered breathingHispanic/Latino populationMetabolic syndromeLongitudinal associationsHispanic Community Health Study/Study of LatinosUS Hispanic/Latino populationIncident metabolic syndromeComorbidity of sleep-disordered breathingRisk factorsHigh riskSleep disordersMultiple cardiovascular risk factorsCardiovascular risk factorsCox regression analysisFollow-up periodHispanic/Latino cohortSmoking statusLatino StudyLongitudinal relationshipManagement of MSMS riskReduced Slow Wave Sleep Is Associated with Increased Risk of Short Stature in Children: A Cross-Sectional Study
Chen Z, Shi Y, Lei F, Feng X, Tan L, Li T, Zhou J, Sun Y, Liao J, Li Y, Yu Z, Jiao J, Wang Y, Sanford L, Vitiello M, Zhang Y, Ren R, Tang X. Reduced Slow Wave Sleep Is Associated with Increased Risk of Short Stature in Children: A Cross-Sectional Study. Nature And Science Of Sleep 2025, 17: 2957-2967. PMID: 41281159, PMCID: PMC12640098, DOI: 10.2147/nss.s475390.Peer-Reviewed Original ResearchNon-OSA childrenObstructive sleep apneaSlow wave sleepObstructive sleep apnea childrenShort statureZ-scoreOSA childrenLogistic regression modelsMean values of Z-scoresReduction of slow wave sleepRisk of short statureHigher oddsValues of Z-scoresPopulation-based evidenceCross-sectional studyNon-OSASleep apneaHeight of childrenPrepubertal childrenRegression modelsSleep qualitySubgroup analysisPolysomnography dataHeight quartileLowest quartileBiological and social reproductive factors and late‐life cognitive function in middle‐aged and older Chinese women
Li X, Zhao W, Zheng H, Liu B, He H, Liu J, Li L, Zhang Y. Biological and social reproductive factors and late‐life cognitive function in middle‐aged and older Chinese women. Alzheimer's & Dementia 2025, 21: e70824. PMID: 41122811, PMCID: PMC12541285, DOI: 10.1002/alz.70824.Peer-Reviewed Original ResearchConceptsOlder Chinese womenReproductive factorsPoor cognitionDementia prevention strategiesLate-life cognitive functionAssociated with late-life cognitionChinese womenLate-life cognitionAssociated with better cognitive performanceLonger reproductive spanChina HealthLifestyle factorsMultivariate regression modelCurrent healthYears of agePrevention strategiesMiddle-agedReproductive spanLive birthsRegression modelsCognitive agingCognitive functionWomenCognitive performanceHealthThe efficacy and safety of pharmacological treatment for major depressive episode with mixed features specifier: a systematic review and meta-analysis
Gao S, Chen Y, Liu J, Zhang Q, Zhao X, Liu B, Zhang Y, Li L, Wang G. The efficacy and safety of pharmacological treatment for major depressive episode with mixed features specifier: a systematic review and meta-analysis. Psychological Medicine 2025, 55: e294. PMID: 41054794, PMCID: PMC12527531, DOI: 10.1017/s0033291725101955.Peer-Reviewed Original ResearchConceptsManic symptomsBD patientsDepressive episodeMood stabilizersBipolar disorderYoung Mania Rating Scale scoresMania Rating Scale scoresRisk of manic switchPharmacological treatmentEffects of antidepressantsMajor depressive episodePrevalence of Major Depressive EpisodeSafety of pharmacological treatmentsRating Scale scoresStandardized mean differenceFeatures specifierManic switchDepressive disorderSubgroup analysisAntipsychoticsPost Hoc AnalysisRelative riskMeta-analysisPrimary efficacy outcomePrimary safety outcome