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Associate Research Scientist
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Comparative Medicine
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Research at a Glance
Publications Timeline
A big-picture view of Vinayak Juvekar's research output by year.
20Publications
559Citations
Publications
2026
Dye‐Combination Micelles for Two‐Photon Phototherapy
Lee D, Juvekar V, Cao Y, Baek J, Kang J, Park M, Sauraj, Sadashivan A, Cho M, Lee G, Park T, Kang H, Shin S, Liu Z, Kim H. Dye‐Combination Micelles for Two‐Photon Phototherapy. Advanced Healthcare Materials 2026, e05557. PMID: 41580942, DOI: 10.1002/adhm.202505557.Peer-Reviewed Original ResearchConceptsTwo-photon excitationHuman colon tumor tissuesIntegrin-mediated uptakeCarrier-free nanoparticlesOrganelle functionType I photosensitizersColon tumor tissuesSubcellular targetingTwo-photon absorptionMitochondria-targeted derivativePeptide sequencesTumor selectivityTumor environmentTherapeutic efficacyTumor tissuesROS generationCancer cellsAmphiphilic propertiesFunctional groupsMinimal invasivenessAntitumor activityClinical translationCo-assemblyEfficient ROS generationPDT efficacy
2024
Development of a small molecule-based two-photon photosensitizer for targeting cancer cells
Lee D, Cao Y, Juvekar V, Sauraj, Noh C, Shin S, Liu Z, Kim H. Development of a small molecule-based two-photon photosensitizer for targeting cancer cells. Journal Of Materials Chemistry B 2024, 12: 12232-12238. PMID: 39469993, DOI: 10.1039/d4tb01706d.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsTarget cancer cellsReactive oxygen speciesPhotodynamic therapyCancer cellsDiverse cell linesInduced ROS productionColon cancer tissuesTwo-photon (TPCell deathLow dark toxicityCancer modelsTwo-photon photosensitizerROS productionCancer selectivityInduce cell damageThree-dimensional spheroidsCell linesTP excitationImaging-guided photodynamic therapyCancer tissuesOxygen speciesTP-PDTOvercoming melanin interference in melanocyte photodynamic therapy with a pyrene-derived two-photon photosensitizer
Juvekar V, Cao Y, Koh C, Lee D, Kwak S, Kim S, Park T, Park S, Liu Z, Kim H. Overcoming melanin interference in melanocyte photodynamic therapy with a pyrene-derived two-photon photosensitizer. Chemical Engineering Journal 2024, 493: 152796. DOI: 10.1016/j.cej.2024.152796.Peer-Reviewed Original ResearchCitationsConceptsPhotodynamic therapyPhotodynamic therapy efficacyPlasma membrane of melanoma cellsMelanoma cellsInhibition of tumor growthReactive oxygen speciesConventional photodynamic therapyTails of miceTreatment of skin diseasesTumor modelTreat melanomaTumor growthMelanin contentMulticellular tumor spheroidsSkin cancerMelanomaVisible light irradiationPDT efficacySkin diseasesMelanin interferenceVisible light excitationBroad absorption spectraChlorin e6ROS generation efficiencyTP-PDTTwo-photon excitation photosensitizers for photodynamic therapy: From small-molecules to nano-complex systems
Juvekar V, Lee D, Park T, Samanta R, Kasar P, Kim C, Rotermund F, Kim H. Two-photon excitation photosensitizers for photodynamic therapy: From small-molecules to nano-complex systems. Coordination Chemistry Reviews 2024, 506: 215711. DOI: 10.1016/j.ccr.2024.215711.Peer-Reviewed Original ResearchCitations
2023
Recent advances in organelle-specific two-photon small-molecule fluorescent probes for bioanalysis in live tissues
Lee H, Juvekar V, Lee D, Kim H. Recent advances in organelle-specific two-photon small-molecule fluorescent probes for bioanalysis in live tissues. TrAC Trends In Analytical Chemistry 2023, 165: 117128. DOI: 10.1016/j.trac.2023.117128.Peer-Reviewed Original ResearchCitationsAltmetricConceptsOrganelle dynamicsEndoplasmic reticulumCellular organellesPlasma membraneTwo-photon probeOrganellesLipid dropletsSmall-molecule fluorescent probesBiological eventsNear-infrared photonsFluorescent probeTwo-photon microscopyExcitation sourceHigh-resolution imagesGolgiLiving samplesMitochondriaReticulumLysosomesProbeLiving tissuesPhoto-physical propertiesPhotonsTwo-photon Fluorescent Probes
Juvekar V, Kim H. Two-photon Fluorescent Probes. 2023, 106-123. DOI: 10.1039/9781839167324-00106.Peer-Reviewed Original ResearchCitations
2022
Two-photon fluorescent probes for quantitative bio-imaging analysis in live tissues
Juvekar V, Lee H, Lee D, Kim H. Two-photon fluorescent probes for quantitative bio-imaging analysis in live tissues. TrAC Trends In Analytical Chemistry 2022, 157: 116787. DOI: 10.1016/j.trac.2022.116787.Peer-Reviewed Original ResearchCitationsConceptsFluorescent probeTwo-photon fluorescent probeDeep tissue imagingNeutral moleculesLow-energy lightTP fluorescent probesExcitation sourceHigh-resolution fluorescence imagingBio-thiolsTarget analytesMetal ionsEnergy lightReactive speciesMillimeter depthLight scatteringNear-infrared windowLiving systemsScatteringDesign strategyProbe design strategyExcitationTP probesAnalytesProbeBio-imaging analysis
2021
Cancer-Targeted Azo Dye for Two-Photon Photodynamic Therapy in Human Colon Tissue
Lee D, Juvekar V, Lee H, Kim E, Noh C, Shin S, Kim H. Cancer-Targeted Azo Dye for Two-Photon Photodynamic Therapy in Human Colon Tissue. Analytical Chemistry 2021, 93: 16821-16827. PMID: 34886662, DOI: 10.1021/acs.analchem.1c03429.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsHuman colon tissueReactive oxygen speciesColon tissuesCancer tissuesColon cancer tissuesCancer ablationCancer managementCancer sensitivityCancer therapyPhotodynamic therapyType I photodynamic therapyTherapyTP treatmentCancer diagnosisSimultaneous cancer diagnosisCancerTissueCellular behaviorTherapeutic assessmentHighly Stable Red-Emissive Ratiometric Probe for Monitoring β‑Galactosidase Activity Using Fluorescence Microscopy and Flow Cytometry
Lee H, Juvekar V, Lee D, Kim S, Kim H. Highly Stable Red-Emissive Ratiometric Probe for Monitoring β‑Galactosidase Activity Using Fluorescence Microscopy and Flow Cytometry. Analytical Chemistry 2021, 93: 14778-14783. PMID: 34705435, DOI: 10.1021/acs.analchem.1c03453.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsCell sorting flow cytometryB-galactosidase activitySorting flow cytometryReporter enzymeFluorescence-activated cell sorting flow cytometryB-galFlow cytometryLiving cellsEnzyme activityB-galactosidaseFluorescence microscopyEnzymeRatiometric imagingOvarian cancerRatiometric probeFluorescent probeMinimal cytotoxicityEmission color changeCytometryProbeA red-emissive two-photon fluorescent probe for mitochondrial sodium ions in live tissue
Juvekar V, Cho M, Lee H, Lee D, Kang H, Song J, Je J, Kim H. A red-emissive two-photon fluorescent probe for mitochondrial sodium ions in live tissue. Chemical Communications 2021, 57: 8929-8932. PMID: 34397047, DOI: 10.1039/d1cc03617c.Peer-Reviewed Original ResearchCitationsMeSH Keywords and Concepts
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