Terril Luce, PhD
Assistant Professor of PsychiatryCards
About
Research
Publications
2025
Genotype‐by‐sex interaction analyses for alcohol use disorder across biobanks
Zhou H, Wang L, Mao Z, Deans P, Kember R, Chen Q, Zakiniaeiz Y, Kohler R, Peltier M, Verplaetse T, Program V, Potenza M, Brennand K, Justice A, Kranzler H, Gelernter J, McKee S. Genotype‐by‐sex interaction analyses for alcohol use disorder across biobanks. Alcohol Clinical And Experimental Research 2025 PMID: 41017299, DOI: 10.1111/acer.70173.Peer-Reviewed Original ResearchExpression quantitative trait lociAlcohol use disorderMillion Veteran ProgramGenotype-by-sexSingle-nucleotide polymorphismsAlcohol use disorder casesAncestry samplesGenetic basisCross-ancestry meta-analysisUse disorderQuantitative trait lociAfrican ancestry samplesPhenome-wide association analysisAlcohol use disorder riskHistory of alcohol addictionSelf-reported historyCross-ancestryTrait lociGenetic variationAssociation analysisMultiple genesLociAlcohol addictionExpression changesBiological underpinningsEmpirical Derivation and Prediction of Treatment Trajectories in Harmonized AUD Clinical Trial Datasets
Kohler R, Zakiniaeiz Y, Verplaetse T, Chavez C, Peltier M, Zhou H, McKee S, Roberts W. Empirical Derivation and Prediction of Treatment Trajectories in Harmonized AUD Clinical Trial Datasets. Addiction Biology 2025, 30: e70069. PMID: 40700031, PMCID: PMC12285684, DOI: 10.1111/adb.70069.Peer-Reviewed Original ResearchConceptsAlcohol use disorderTreatment response phenotypesAlcohol use disorder treatmentTreatment response trajectoriesAUD-related phenotypesFollow-up analysisBaseline drinkingPhase of treatmentUse disorderAlcohol consumption patternsPhase 2 randomized clinical trialDrinking dataResponse trajectoriesAlcohol usePatient responsePhase 3 trialResponse phenotypesExploratory analysisAlcohol consumptionTreatment trajectoryDrinking ratesNIAAANo significant differenceMild drinkersPatient's clinical needsAlcohol use during pregnancy: the impact of social determinants of health on alcohol consumption among pregnant women
Peltier M, Verplaetse T, Bici V, Mokwuah A, Chavez C, Zakiniaeiz Y, Kohler R, Garcia-Rivas V, Banini B, Zhou H, Raval N, Pittman B, McKee S. Alcohol use during pregnancy: the impact of social determinants of health on alcohol consumption among pregnant women. Biology Of Sex Differences 2025, 16: 49. PMID: 40598644, PMCID: PMC12219128, DOI: 10.1186/s13293-025-00731-6.Peer-Reviewed Original ResearchConceptsSocial determinants of healthDeterminants of healthImpact of SDoHMonthly binge drinkingMonth alcohol useAlcohol useLikelihood of alcohol useSocial determinantsLikelihood of binge drinkingPregnant womenBinge drinkingImpact of social determinants of healthAlcohol consumptionNational Survey of Drug Use and HealthNational surveyMethodsCross-sectional dataDrug Use and HealthRates of prenatal alcohol exposureHigh school educationCriminal justice involvementPast-month alcohol useHealthcare providersSDOHTime of alcohol consumptionPrenatal alcohol exposurePreclinical and clinical sex differences in the effects of alcohol on measures of brain dopamine: a systematic review
Barrios N, Riordan W, Garcia-Rivas V, Peltier M, Roberts W, Verplaetse T, Kohler R, Zhou H, Banini B, McKee S, Cosgrove K, Zakiniaeiz Y. Preclinical and clinical sex differences in the effects of alcohol on measures of brain dopamine: a systematic review. Biology Of Sex Differences 2025, 16: 24. PMID: 40200334, PMCID: PMC11980350, DOI: 10.1186/s13293-025-00706-7.Peer-Reviewed Original ResearchConceptsAlcohol use disorderAlcohol-induced dopamine releaseEffects of alcoholSex differencesAlcohol exposureDopamine measurementsMu-opioid receptorsDopamine releaseEffects of sexProgression of alcohol use disorderDopamine D1 receptor availabilityAlcohol use disorder developmentEffects of prenatal alcohol exposureD1 receptor availabilityStriatal dopamine concentrationsAir-exposed controlsAlcohol-exposed animalsMu-opioid receptor activationPrenatal alcohol exposureDuration of alcohol exposureVentral striatumBrain dopamineReward processingNeurobiological mechanismsReceptor availabilitySex-based Influences on White Matter Tract Integrity in Alcohol Use Disorder: a Systematic Review
Barrios N, Nartey N, Yue J, Riordan W, Kohler R, Verplaetse T, Roberts W, Carretta R, Banini B, Zhou H, Garcia-Rivas V, Blackford J, Zakiniaeiz Y. Sex-based Influences on White Matter Tract Integrity in Alcohol Use Disorder: a Systematic Review. Current Addiction Reports 2025, 12: 10. PMID: 40343159, PMCID: PMC12058214, DOI: 10.1007/s40429-025-00624-z.Peer-Reviewed Original ResearchWhite matter tract integrityAlcohol use disorderTract integritySex differencesUse disorderNeurotoxic effects of alcoholAlcohol-related health consequencesExamined sex differencesEffects of alcoholAlcohol use historyWell-characterized sampleDiffusion magnetic resonance imagingEvidence of sex-related differencesNeurobiological mechanismsPsychiatric comorbiditiesSubstance useSystematic reviewSex-related differencesNeurotoxic effectsIndividualized treatment optionsMagnetic resonance imagingDisordersAlcoholGoogle Scholar databasesTreatment options
2024
Digital phenotyping from wearables using AI characterizes psychiatric disorders and identifies genetic associations
Liu J, Borsari B, Li Y, Liu S, Gao Y, Xin X, Lou S, Jensen M, Garrido-Martín D, Verplaetse T, Ash G, Zhang J, Girgenti M, Roberts W, Gerstein M. Digital phenotyping from wearables using AI characterizes psychiatric disorders and identifies genetic associations. Cell 2024, 188: 515-529.e15. PMID: 39706190, PMCID: PMC12278733, DOI: 10.1016/j.cell.2024.11.012.Peer-Reviewed Original ResearchGenome-wide association studiesCase-control genome-wide association studyMultivariate genome-wide association studyGenetic lociAssociation studiesGenetic dataGenetic associationPhenotypeGeneticsEnvironmental factorsDetection powerELFN1Adolescent Brain Cognitive DevelopmentLociGenesPsychiatric disordersADORA3Digital phenotypingGender differences in alcohol use disorder trends from 2009–2019: An intersectional analysis
Verplaetse T, Carretta R, Struble C, Pittman B, Roberts W, Zakiniaeiz Y, Peltier M, McKee S. Gender differences in alcohol use disorder trends from 2009–2019: An intersectional analysis. Alcohol 2024, 123: 101-107. PMID: 39579801, PMCID: PMC11871986, DOI: 10.1016/j.alcohol.2024.11.003.Peer-Reviewed Original ResearchRates of alcohol use disordersAlcohol use disorderMarital statusRates of alcohol useDrug Use and Health (NSDUHNational Survey on Drug Use and Health (NSDUHGender differencesIntersectional lensIntersectional analysisEffects of sociodemographic variablesDisorder trendsHousehold incomeNational surveyEmployment statusSociodemographic variablesAlcohol useEducation levelHeightened riskGenderLogistic regressionDemographic characteristicsEmploymentIncomeUrbanizationAdult menThe Causes and Consequences of Stigma Among Individuals Involved in the Criminal Legal System: A Systematic Review
Moore K, Phillips S, Kromash R, Siebert S, Roberts W, Peltier M, Smith M, Verplaetse T, Marotta P, Burke C, Allison G, McKee S. The Causes and Consequences of Stigma Among Individuals Involved in the Criminal Legal System: A Systematic Review. Stigma And Health 2024, 9: 224-235. PMID: 39381322, PMCID: PMC11456775, DOI: 10.1037/sah0000483.Peer-Reviewed Original ResearchImaging a putative marker of brain cortisol regulation in alcohol use disorder
Verplaetse T, Hillmer A, Bhatt S, Rusowicz A, Li S, Nabulsi N, Matuskey D, Huang Y, McKee S, Cosgrove K. Imaging a putative marker of brain cortisol regulation in alcohol use disorder. Neurobiology Of Stress 2024, 29: 100609. PMID: 38304303, PMCID: PMC10832501, DOI: 10.1016/j.ynstr.2024.100609.Peer-Reviewed Original ResearchAlcohol use disorderAnterior cingulate cortexDrinking days/weekModerate to severe alcohol use disorderHealthy controlsHypothalamic-pituitary-adrenal (HPA) axisSevere alcohol use disorderPositron emission tomographyHPA axis dysfunctionHPA axis functionRelease of glucocorticoid hormonesAlcohol consumptionAssociated with drinkingVentromedial PFCCingulate cortexHigh-resolution research tomographHPA activityUse disorderDrinking episodesCortisol regulationAxis functionVmPFCPeripheral cortisolBrain availabilityDisordered backgroundThe role of neurosteroids in posttraumatic stress disorder and alcohol use disorder: A review of 10 years of clinical literature and treatment implications
Peltier M, Verplaetse T, Altemus M, Zakiniaeiz Y, Ralevski E, Mineur Y, Gueorguieva R, Picciotto M, Cosgrove K, Petrakis I, McKee S. The role of neurosteroids in posttraumatic stress disorder and alcohol use disorder: A review of 10 years of clinical literature and treatment implications. Frontiers In Neuroendocrinology 2024, 73: 101119. PMID: 38184208, PMCID: PMC11185997, DOI: 10.1016/j.yfrne.2023.101119.Peer-Reviewed Original ResearchPosttraumatic stress disorderAlcohol use disorderStress disorderContext of PTSDPTSD/AUDConcurrent posttraumatic stress disorderUnderlying neurobiological mechanismsUse disordersAlcohol-related variablesNeurobiological mechanismsPTSD diagnosisTreatment developmentTreatment implicationsBody of literatureNovel interventionsClinical literatureRole of neurosteroidsDisordersTreatment outcomesYears of researchAlcohol consumptionExogenous pregnenolonePharmacological treatmentBiological variablesAllopregnanolone
Clinical Trials
Current Trials
The Effect of Acute Stress and Inflammation on Drinking
HIC ID2000028772RolePrincipal InvestigatorPrimary Completion Date06/30/2022Recruiting ParticipantsGenderBothAge21 years - 65 yearsEligibility for Participation in Neuroimaging Studies
HIC ID2000027842RoleSub InvestigatorPrimary Completion Date12/31/2023Recruiting ParticipantsHPA axis function in the brains of PTSD, Trauma Exposed, or Otherwise Healthy research participants utilizing PET and MRI imaging
HIC ID2000028748RoleSub InvestigatorPrimary Completion Date08/31/2025Recruiting ParticipantsGenderBothAge18 years - 55 yearsCombining Varenicline and Guanfacine for Smoking Cessation
HIC ID2000026630RoleSub InvestigatorPrimary Completion Date09/30/2020Recruiting ParticipantsGenderBothAge18+ yearsBehavioral and Neurochemical Mechanisms Underlying Stress-Precipitated Drinking
HIC ID2000021685RolePrincipal InvestigatorPrimary Completion Date09/30/2022Recruiting ParticipantsGenderBothAge21 years - 55 years
Academic Achievements & Community Involvement
News
News
- December 19, 2024Source: Yale News
Using Smartwatches to Better Understand Psychiatric Illness
- October 15, 2024
Verplaetse, Snell, Harvanek Awarded Brain & Behavior Research Foundation Grants
- November 02, 2022
Verplaetse Presents to NIDA and NIAAA