Tanina Arab, PhD
she/her/hers
Associate Research ScientistCards
About
Research
Publications
2025
Aberrant splicing exonizes C9orf72 repeat expansion in ALS/FTD
Yang S, Wijegunawardana D, Sheth U, Veire A, Salgado J, Arab T, Agrawal M, Zhou J, Pereira J, Gendron T, Guo J. Aberrant splicing exonizes C9orf72 repeat expansion in ALS/FTD. Nature Neuroscience 2025, 28: 2034-2043. PMID: 40790269, PMCID: PMC12720984, DOI: 10.1038/s41593-025-02039-5.Peer-Reviewed Original ResearchSerine/arginine-rich splicing factor 1Nucleotide repeat expansionsSpliced isoformsDipeptide repeat (DPR) proteinsRepeat expansionAlternative 5' splice sitesCytoplasmic translation machineryAberrant splicing isoformsPatient-derived fibroblastsSplicing factor 1Amyotrophic lateral sclerosisFrontotemporal dementiaC9orf72 repeat expansionPathogen transcriptsRNA segmentsTranslation machinerySplice siteC9-ALS/FTDAberrant splicingExon 1Antisense oligonucleotidesRNAFactor 1IsoformsLateral sclerosis
2024
Characterization of spinal cord tissue-derived extracellular vesicles in neuroinflammation
Jank L, Kesharwani A, Ryu T, Joshi D, Ladakis D, Smith M, Singh S, Arab T, Witwer K, Calabresi P, Na C, Bhargava P. Characterization of spinal cord tissue-derived extracellular vesicles in neuroinflammation. Journal Of Neuroinflammation 2024, 21: 154. PMID: 38851724, PMCID: PMC11162576, DOI: 10.1186/s12974-024-03147-y.Peer-Reviewed Original ResearchConceptsExperimental autoimmune encephalomyelitisCentral nervous systemMultiple sclerosisExtracellular vesiclesInduction of experimental autoimmune encephalomyelitisNeuroinflammatory modelModel of MSBlood-brain barrierAutoimmune encephalomyelitisImmune modulationGlial cell typesPlasma biomarkersProteomic changesDisease-associated changesTherapeutic vehiclesNervous systemDisease processCell typesSynaptic proteinsEV biomarkersPathological processesBiomarkersSynaptic pathologyMinimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches.
Welsh JA, Goberdhan DCI, O'Driscoll L, Buzas EI, Blenkiron C, Bussolati B, Cai H, Di Vizio D, Driedonks TAP, Erdbrügger U, Falcon-Perez JM, Fu QL, Hill AF, Lenassi M, Lim SK, Mahoney MG, Mohanty S, Möller A, Nieuwland R, Ochiya T, Sahoo S, Torrecilhas AC, Zheng L, Zijlstra A, Abuelreich S, Bagabas R, Bergese P, Bridges EM, Brucale M, Burger D, Carney RP, Cocucci E, Crescitelli R, Hanser E, Harris AL, Haughey NJ, Hendrix A, Ivanov AR, Jovanovic-Talisman T, Kruh-Garcia NA, Ku'ulei-Lyn Faustino V, Kyburz D, Lässer C, Lennon KM, Lötvall J, Maddox AL, Martens-Uzunova ES, Mizenko RR, Newman LA, Ridolfi A, Rohde E, Rojalin T, Rowland A, Saftics A, Sandau US, Saugstad JA, Shekari F, Swift S, Ter-Ovanesyan D, Tosar JP, Useckaite Z, Valle F, Varga Z, van der Pol E, van Herwijnen MJC, Wauben MHM, Wehman AM, Williams S, Zendrini A, Zimmerman AJ, MISEV Consortium, Théry C, Witwer KW. Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches. J Extracell Vesicles 2024, 13: e12404. PMID: 38326288, DOI: 10.1002/jev2.12404.Peer-Reviewed Original Research
2023
Towards a human brain EV atlas: Characteristics of EVs from different brain regions, including small RNA and protein profiles (4/2023)
Huang Y, Arab T, Russell A, Mallick E, Nagaraj R, Gizzie E, Redding‐Ochoa J, Troncoso J, Pletnikova O, Turchinovich A, Routenberg D, Witwer K. Towards a human brain EV atlas: Characteristics of EVs from different brain regions, including small RNA and protein profiles (4/2023). Interdisciplinary Medicine 2023, 1 DOI: 10.1002/inmd.12064.Peer-Reviewed Original ResearchToward a human brain extracellular vesicle atlas: Characteristics of extracellular vesicles from different brain regions, including small RNA and protein profiles
Huang Y, Arab T, Russell A, Mallick E, Nagaraj R, Gizzie E, Redding‐Ochoa J, Troncoso J, Pletnikova O, Turchinovich A, Routenberg D, Witwer K. Toward a human brain extracellular vesicle atlas: Characteristics of extracellular vesicles from different brain regions, including small RNA and protein profiles. Interdisciplinary Medicine 2023, 1: e20230016. PMID: 38089920, PMCID: PMC10712435, DOI: 10.1002/inmd.20230016.Peer-Reviewed Original ResearchBrain-derived EVsExtracellular vesiclesCharacteristics of extracellular vesiclesEV heterogeneityBrain-derived extracellular vesiclesBrain regionsProtein profilesRNA contentCell typesCentral nervous systemParticle yieldsPathological functionsRNAProteinVesiclesAnatomical brain regionsPostcentral gyrusExosomes, microvesicles, and other extracellular vesicles—a Keystone Symposia report
Cable J, Witwer K, Coffey R, Milosavljevic A, von Lersner A, Jimenez L, Pucci F, Barr M, Dekker N, Barman B, Humphrys D, Williams J, de Palma M, Guo W, Bastos N, Hill A, Levy E, Hantak M, Crewe C, Aikawa E, Adamczyk A, Zanotto T, Ostrowski M, Arab T, Rabe D, Sheikh A, da Silva D, Jones J, Okeoma C, Gaborski T, Zhang Q, Gololobova O. Exosomes, microvesicles, and other extracellular vesicles—a Keystone Symposia report. Annals Of The New York Academy Of Sciences 2023, 1523: 24-37. PMID: 36961472, PMCID: PMC10715677, DOI: 10.1111/nyas.14974.Peer-Reviewed Original ResearchConceptsExtracellular vesiclesBiology of extracellular vesiclesExtracellular environmentTissue homeostasisEV fieldKeystone SymposiumDistant tissuesPrognostic biomarkerInvasive diagnosticsClinical utilityVesiclesMinimally invasive diagnosticsDrug delivery vehiclesBioactive moleculesRNASignal particlesProteinHomeostasisTissue
2022
Brain Tissue-Derived Extracellular Vesicles in Alzheimer’s Disease Display Altered Key Protein Levels Including Cell Type-Specific Markers
Huang Y, Driedonks T, Cheng L, Rajapaksha H, Routenberg D, Nagaraj R, Redding J, Arab T, Powell B, Pletniková O, Troncoso J, Zheng L, Hill A, Mahairaki V, Witwer K. Brain Tissue-Derived Extracellular Vesicles in Alzheimer’s Disease Display Altered Key Protein Levels Including Cell Type-Specific Markers. Journal Of Alzheimer’s Disease 2022, 90: 1057-1072. PMID: 36213994, PMCID: PMC9741741, DOI: 10.3233/jad-220322.Peer-Reviewed Original ResearchConceptsAlzheimer's diseaseCell type-specific surface markersExtracellular vesiclesP-tauIntact extracellular vesiclesT-tauCell type-specific markersLevels of T-tauAntioxidant peroxiredoxinAD patientsProteomic differencesMolecular profilingType-specific markersProteomicsAD mechanismsCell-specific markersTotal-tauVesiclesProtein levelsPeroxiredoxinBrain tissueTauAlzheimerMarkersCell markersRelationships of APOE Genotypes With Small RNA and Protein Cargo of Brain Tissue Extracellular Vesicles From Patients With Late-Stage AD
Huang Y, Driedonks T, Cheng L, Rajapaksha H, Turchinovich A, Routenberg D, Nagaraj R, Redding-Ochoa J, Arab T, Powell B, Pletnikova O, Troncoso J, Zheng L, Hill A, Mahairaki V, Witwer K. Relationships of APOE Genotypes With Small RNA and Protein Cargo of Brain Tissue Extracellular Vesicles From Patients With Late-Stage AD. Neurology Genetics 2022, 8: e200026. PMID: 36405397, PMCID: PMC9667865, DOI: 10.1212/nxg.0000000000200026.Peer-Reviewed Original ResearchSmall RNAsLate-stage ADAD brainProtein profilesAlzheimer's diseaseProtein cargoExtracellular vesiclesLate-stage AD brainsSource tissuesEV-associated moleculesBinding partner interactionsSporadic Alzheimer's diseasePotential regulatory roleBrain-derived EVsIndividual RNAsGene regulationAD pathogenesisRNA sequencingProteomic analysisBrain-derived extracellular vesiclesAD pathophysiologyBioinformatics analysisAD developmentAD progressionRNANeutral sphingomyelinase 2 inhibition attenuates extracellular vesicle release and improves neurobehavioral deficits in murine HIV
Zhu X, Hollinger K, Huang Y, Borjabad A, Kim B, Arab T, Thomas A, Moniruzzaman M, Lovell L, Turchinovich A, Witwer K, Volsky D, Haughey N, Slusher B. Neutral sphingomyelinase 2 inhibition attenuates extracellular vesicle release and improves neurobehavioral deficits in murine HIV. Neurobiology Of Disease 2022, 169: 105734. PMID: 35462006, PMCID: PMC9202342, DOI: 10.1016/j.nbd.2022.105734.Peer-Reviewed Original ResearchConceptsMajor depressive disorderEcoHIV-infected miceCognitive impairmentAssociated with major depressive disorderRates of cognitive impairmentMiR-429-3pDepressive disorderCognitive deficitsBehavioral testsBiochemical effectsWeeks of treatmentNeurobehavioral deficitsExtracellular vesiclesBrain-derived extracellular vesiclesDaily treatmentDeficitsEcoHIV infectionNSMase2 inhibitionInhibition of nSMase2General populationMiR-200c-3pMiR-200b-3pTherapeutic strategiesEcoHIVExtracellular vesicle release
2021
Characterization of extracellular vesicles and synthetic nanoparticles with four orthogonal single‐particle analysis platforms
Arab T, Mallick E, Huang Y, Dong L, Liao Z, Zhao Z, Gololobova O, Smith B, Haughey N, Pienta K, Slusher B, Tarwater P, Tosar J, Zivkovic A, Vreeland W, Paulaitis M, Witwer K. Characterization of extracellular vesicles and synthetic nanoparticles with four orthogonal single‐particle analysis platforms. Journal Of Extracellular Vesicles 2021, 10: e12079. PMID: 33850608, PMCID: PMC8023330, DOI: 10.1002/jev2.12079.Peer-Reviewed Original Research
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