Takeshi Ito, MD, PhD
Associate Research ScientistAbout
Research
Publications
2024
Booster COVID-19 mRNA vaccination ameliorates impaired B-cell but not T-cell responses in older adults
Kometani K, Yorimitsu T, Jo N, Yamaguchi E, Kikuchi O, Fukahori M, Sawada T, Tsujimoto Y, Sunami A, Li M, Ito T, Pretemer Y, Gao Y, Hidaka Y, Yamamoto M, Kaku N, Nakagama Y, Kido Y, Grifoni A, Sette A, Nagao M, Morita S, Nakajima T, Muto M, Hamazaki Y. Booster COVID-19 mRNA vaccination ameliorates impaired B-cell but not T-cell responses in older adults. Frontiers In Immunology 2024, 15: 1455334. PMID: 39717779, PMCID: PMC11663736, DOI: 10.3389/fimmu.2024.1455334.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge FactorsAgedAged, 80 and overAntibodies, ViralB-LymphocytesCD8-Positive T-LymphocytesCOVID-19COVID-19 VaccinesFemaleHumansImmunity, HumoralImmunization, SecondaryImmunoglobulin GImmunologic MemoryMaleMemory B CellsMiddle AgedmRNA VaccinesSARS-CoV-2Spike Glycoprotein, CoronavirusYoung AdultConceptsB cell responsesT cell responsesB cellsT cellsBooster vaccinationT cell-mediated cellular immunityCD8+ T cell responsesCytotoxic CD8+ T cell responsesReduced PD-1 expressionMemory T cell activationMemory B cell responsesCOVID-19 mRNA booster vaccinationPD-1 expressionCOVID-19 mRNA vaccinesMemory T cellsImpaired humoral immunityImpaired B cellYoung adultsT cell activationMRNA booster vaccinationEnhanced IgG responseSpike-specificCellular immunityMRNA vaccinesAge-associated differencesNeutrophils insert elastase into hepatocytes to regulate calcium signaling in alcohol-associated hepatitis
Ogino N, Leite M, Guerra M, Kruglov E, Asashima H, Hafler D, Ito T, Pereira J, Peiffer B, Sun Z, Ehrlich B, Nathanson M. Neutrophils insert elastase into hepatocytes to regulate calcium signaling in alcohol-associated hepatitis. Journal Of Clinical Investigation 2024, 134: e171691. PMID: 38916955, PMCID: PMC11324315, DOI: 10.1172/jci171691.Peer-Reviewed Original ResearchAlcohol-associated hepatitisReduced cell proliferationCalcium channel expressionCalcium signaling mechanismsIntracellular calcium channelsCell proliferationRegulate calcium signalingNeutrophil extracellular trapsChannel expressionNeutrophil granule proteinsCalcium channelsNeutrophil infiltrationPatient specimensGranule proteasesMouse modelHealthy subjectsLiver diseaseExtracellular trapsCalcium signalingSerpin E2NeutrophilsElastase activityHepatitisTissue remodelingSignaling mechanisms
2022
Dysregulated stem cell niches and altered lymphocyte recirculation cause B and T cell lymphopenia in WHIM syndrome
Zehentmeier S, Lim VY, Ma Y, Fossati J, Ito T, Jiang Y, Tumanov AV, Lee HJ, Dillinger L, Kim J, Csomos K, Walter JE, Choi J, Pereira JP. Dysregulated stem cell niches and altered lymphocyte recirculation cause B and T cell lymphopenia in WHIM syndrome. Science Immunology 2022, 7: eabo3170. PMID: 36149943, PMCID: PMC9614684, DOI: 10.1126/sciimmunol.abo3170.Peer-Reviewed Original ResearchConceptsSecondary lymphoid organsWHIM syndromeMesenchymal stem cellsInterleukin-7B lymphopeniaBone marrowBM mesenchymal stem cellsT cell numbersIL-7 productionT-cell lymphopeniaLymphotoxin beta receptorEarly progenitor stageLymphoid organsCell lymphopeniaMouse modelBeta receptorsB cellsB cell developmentLymphopeniaStromal cellsLeukocyte retentionSyndromeGOF mutationsLymphopoietic activityCritical pathways
2020
Bone Marrow Endothelial Cells Take Up Blood-Borne Immune Complexes via Fcγ Receptor IIb2 in an Erythropoietin-Dependent Manner.
Ito T, Kometani K, Minato N, Hamazaki Y. Bone Marrow Endothelial Cells Take Up Blood-Borne Immune Complexes via Fcγ Receptor IIb2 in an Erythropoietin-Dependent Manner. The Journal Of Immunology 2020, 205: 2008-2015. PMID: 32907997, DOI: 10.4049/jimmunol.1901101.Peer-Reviewed Original ResearchConceptsImmune complexesHealthy miceBone marrowUptake of ICsEndothelial cellsAdministration of erythropoietinSoluble immune complexesLiver reticuloendothelial systemSinusoidal endothelial cellsBone marrow endothelial cellsMarrow endothelial cellsEPO administrationKupffer cellsTransgenic miceAnemic conditionBM erythroblastsReticuloendothelial systemSinusoidal vasculatureMiceBMECsEPO receptorHematopoietic cellsAdministrationEPOHematopoietic nicheSelective expression of claudin-5 in thymic endothelial cells regulates the blood–thymus barrier and T-cell export
Nagatake T, Zhao Y, Ito T, Itoh M, Kometani K, Furuse M, Saika A, Node E, Kunisawa J, Minato N, Hamazaki Y. Selective expression of claudin-5 in thymic endothelial cells regulates the blood–thymus barrier and T-cell export. International Immunology 2020, 33: 171-182. PMID: 33038259, PMCID: PMC7936066, DOI: 10.1093/intimm/dxaa069.Peer-Reviewed Original ResearchConceptsCortico-medullary junctionBlood-thymus barrierEndothelial cellsClaudin-5Biotin tracerCortical vasculatureBlood-borne moleculesCentral tolerance inductionT cell exportThymic endothelial cellsEC cell linesSphingosine-1-PhosphateT cell developmentDendritic cellsThymic cortexTolerance inductionTrans-endothelial resistanceThymocyte egressVascular permeabilityThymic microenvironmentMature thymocytesMedullaBlood circulationSelective expressionMedullary parenchyma
2018
A single-center retrospective analysis of extramedullary relapse after allogeneic stem cell transplantation for myeloid neoplasms
Ito T, Kondo T, Yamashita K, Takaori-Kondo A. A single-center retrospective analysis of extramedullary relapse after allogeneic stem cell transplantation for myeloid neoplasms. Journal Of Hematopoietic Cell Transplantation 2018, 7: 138-144. DOI: 10.7889/hct-18-004.Peer-Reviewed Original Research
2017
Bone marrow endothelial cells induce immature and mature B cell egress in response to erythropoietin
Ito T, Hamazaki Y, Takaori-Kondo A, Minato N. Bone marrow endothelial cells induce immature and mature B cell egress in response to erythropoietin. Cell Structure And Function 2017, 42: 17018. PMID: 29070774, DOI: 10.1247/csf.17018.Peer-Reviewed Original ResearchConceptsBone marrow endothelial cellsMarrow endothelial cellsStromal cellsEndothelial cellsEmergency hematopoiesisBone marrow stromal cellsMature B cellsPhosphorylation of STAT5Immature B cellsSpecific lineagesB cell egressCxcl12 transcriptionMarrow stromal cellsB cell retentionErythropoietin receptorBone marrow microenvironmentBone marrowHematopoietic stemB cellsPrecursor cellsPhenylhydrazine-induced hemolytic anemiaExpression levelsErythropoietin stimulationMesenchymal stromal cellsMarrow microenvironment
2014
In vivo imaging reveals PKA regulation of ERK activity during neutrophil recruitment to inflamed intestines
Mizuno R, Kamioka Y, Kabashima K, Imajo M, Sumiyama K, Nakasho E, Ito T, Hamazaki Y, Okuchi Y, Sakai Y, Kiyokawa E, Matsuda M. In vivo imaging reveals PKA regulation of ERK activity during neutrophil recruitment to inflamed intestines. Journal Of Experimental Medicine 2014, 211: 1123-1136. PMID: 24842369, PMCID: PMC4042632, DOI: 10.1084/jem.20132112.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnti-Inflammatory Agents, Non-SteroidalBenzamidesCell AdhesionCell MovementCyclic AMP-Dependent Protein KinasesDiphenylamineEndothelial CellsEnteritisExtracellular Signal-Regulated MAP KinasesFemaleFluorescence Resonance Energy TransferGreen Fluorescent ProteinsIntestine, SmallMaleMethyl EthersMiceMice, Inbred C57BLMice, TransgenicMicroscopy, Fluorescence, MultiphotonNaphthalenesNeutrophil InfiltrationNeutrophilsPhenylbutyratesReceptors, Prostaglandin E, EP4 SubtypeTime-Lapse ImagingConceptsNonsteroidal antiinflammatory drugsExtracellular signal-regulated kinaseChemical mediatorsNeutrophil recruitmentEndothelial cellsInterstitial tissueSuch chemical mediatorsInflamed intestinal tissueProstaglandin receptor EP4Migration of neutrophilsProtein kinase ANeutrophil recruitment cascadeInflamed intestineEP4 agonistReceptor EP4ERK activityEP4 receptorsAntiinflammatory drugsIntravenous administrationInflammatory sitesIntestinal tissueTransgenic miceSignal-regulated kinaseNeutrophilsRecruitment cascade
2012
Splenic Irradiation as a Component of a Reduced-Intensity Conditioning Regimen for Hematopoietic Stem Cell Transplantation in Myelofibrosis with Massive Splenomegaly
Ito T, Akagi K, Kondo T, Kawabata H, Ichinohe T, Takaori-Kondo A. Splenic Irradiation as a Component of a Reduced-Intensity Conditioning Regimen for Hematopoietic Stem Cell Transplantation in Myelofibrosis with Massive Splenomegaly. The Tohoku Journal Of Experimental Medicine 2012, 228: 295. PMID: 23117264, DOI: 10.1620/tjem.228.295.Peer-Reviewed Original ResearchConceptsHematopoietic stem cell transplantationAllogeneic hematopoietic stem cell transplantationStem cell transplantationSplenic irradiationMassive splenomegalyCell transplantationSurgical morbidityPrimary myelofibrosisPeripheral blood stem cell transplantationBlood stem cell transplantationReduced-intensity conditioning regimenReduced-intensity conditioning regimensUnrelated bone marrow transplantationPost-essential thrombocythemia myelofibrosisOnly curative strategyHLA-identical siblingsProportion of patientsTime of transplantationBone marrow transplantationBone marrow fibrosisDonor cell engraftmentSimilar clinical conditionsConditioning regimenConditioning regimensElderly patients
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