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Research Associate 2, MS
Research
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Research at a Glance
Yale Co-Authors
Frequent collaborators of Srividhya Venkatesan's published research.
Publications Timeline
A big-picture view of Srividhya Venkatesan's research output by year.
Nikhil Joshi, PhD
Begona Lainez-Mas
Dhanpat Jain, MD, MBBS
Hong Zheng
Jennifer Loza
Jiaming He
10Publications
359Citations
Publications
2025
Distinct T cell functions enable efficient immunoediting and prevent tumor emergence of developing sarcomas
Cheung J, Hunt B, Wahed S, Cheng E, Connolly K, Venkatesan S, Loza J, Bansal I, Fagerberg E, Kessler E, Riffard C, Buck J, Attanasio J, Borr E, Wei W, William I, Fitzgerald B, Joshi N. Distinct T cell functions enable efficient immunoediting and prevent tumor emergence of developing sarcomas. Cancer Cell 2025, 43: 2311-2326.e4. PMID: 41043437, PMCID: PMC12693725, DOI: 10.1016/j.ccell.2025.09.005.Peer-Reviewed Original ResearchAltmetric
2023
PD-1 maintains CD8 T cell tolerance towards cutaneous neoantigens
Damo M, Hornick N, Venkat A, William I, Clulo K, Venkatesan S, He J, Fagerberg E, Loza J, Kwok D, Tal A, Buck J, Cui C, Singh J, Damsky W, Leventhal J, Krishnaswamy S, Joshi N. PD-1 maintains CD8 T cell tolerance towards cutaneous neoantigens. Nature 2023, 619: 151-159. PMID: 37344588, PMCID: PMC10989189, DOI: 10.1038/s41586-023-06217-y.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsEffector CD8 T cellsCD8 T cellsAntigen-specific effector CD8 T cellsAntigen-specific CD8 T cellsAntigen-expressing cellsT cell tolerancePD-1T cellsAdverse eventsCell toleranceCD8 T cell toleranceImmune-related adverse eventsPeripheral T cell repertoirePeripheral T cell toleranceNon-lesional skinT cell repertoireT-cell antigensPeripheral toleranceCheckpoint receptorsSkin biopsiesLocal infiltrationLocal pathologyCell repertoireMouse modelSkin tolerance
2022
An In Vivo Model for Elucidating the Role of an Erythroid-Specific Isoform of Nuclear Export Protein Exportin 7 (Xpo7) in Murine Erythropoiesis
Modepalli S, Martinez-Morilla S, Venkatesan S, Fasano J, Paulsen K, Görlich D, Hattangadi S, Kupfer G. An In Vivo Model for Elucidating the Role of an Erythroid-Specific Isoform of Nuclear Export Protein Exportin 7 (Xpo7) in Murine Erythropoiesis. Experimental Hematology 2022, 114: 22-32. PMID: 35973480, PMCID: PMC10165728, DOI: 10.1016/j.exphem.2022.08.001.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsErythroid-specific isoformStress erythropoiesisNuclear condensationPenetrant embryonic lethalityStress response factorsGene-targeted mouse modelsEmbryonic lethalityTerminal erythropoiesisDefinitive erythropoiesisExportin-7Cell divisionSteady-state erythropoiesisUbiquitous isoformErythroid isoformComplete knockdownMurine erythropoiesisSpecific isoformsXPO7Response factorIsoformsFunctional differencesExon 4Fetal liverErythropoiesisExpression
2021
Roles of Bone Morphogenetic Protein Receptor 1A in Germinal Centers and Long-Lived Humoral Immunity
Tomayko MM, Karaaslan S, Lainez B, Conter LJ, Song E, Venkatesan S, Mishina Y, Shlomchik MJ. Roles of Bone Morphogenetic Protein Receptor 1A in Germinal Centers and Long-Lived Humoral Immunity. ImmunoHorizons 2021, 5: 284-297. PMID: 33975878, PMCID: PMC12221147, DOI: 10.4049/immunohorizons.2100019.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsBone marrow-resident plasma cellsBone morphogenetic protein receptor 1AMemory B cellsMultiple stem cell populationsGene deletionStrong selective pressureGC B cellsStem cell populationGerminal centersB cellsReceptor 1aSelective pressureExpression studiesResultant establishmentNovel roleClass-switched memory B cellsEGFP reporter mice
2018
miR-181a regulates erythroid enucleation via the regulation of Xpo7 expression
Figueroa A, Fasano JD, Martinez-Morilla S, Venkatesan S, Kupfer G, Hattangadi SM. miR-181a regulates erythroid enucleation via the regulation of Xpo7 expression. Haematologica 2018, 103: e341-e344. PMID: 29567782, PMCID: PMC6068031, DOI: 10.3324/haematol.2017.171785.Commentaries, Editorials and LettersCitationsAltmetric
2014
Histones to the cytosol: exportin 7 is essential for normal terminal erythroid nuclear maturation
Hattangadi SM, Martinez-Morilla S, Patterson HC, Shi J, Burke K, Avila-Figueroa A, Venkatesan S, Wang J, Paulsen K, Görlich D, Murata-Hori M, Lodish HF. Histones to the cytosol: exportin 7 is essential for normal terminal erythroid nuclear maturation. Blood 2014, 124: 1931-1940. PMID: 25092175, PMCID: PMC4168348, DOI: 10.1182/blood-2013-11-537761.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsMost nuclear proteinsExportin-7Nuclear proteinsLate erythroblastsNuclear protein exportTerminal erythroid maturationFetal liver erythroblastsNuclear export proteinErythroid nucleiProtein exportTerminal erythropoiesisHistone H2AChromatin condensationErythroid differentiationExport proteinErythroid maturationNuclear condensationProteomic examinationProteinXPO7HistonesHemoglobin accumulationSevere inhibitionErythroblastsFetal liver
2011
Memory T cells from minor histocompatibility antigen–vaccinated and virus-immune donors improve GVL and immune reconstitution
Li N, Matte-Martone C, Zheng H, Cui W, Venkatesan S, Tan HS, McNiff J, Demetris AJ, Roopenian D, Kaech S, Shlomchik WD. Memory T cells from minor histocompatibility antigen–vaccinated and virus-immune donors improve GVL and immune reconstitution. Blood 2011, 118: 5965-5976. PMID: 21917752, PMCID: PMC3228506, DOI: 10.1182/blood-2011-07-367011.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsMeSH KeywordsAnimalsCell ProliferationGraft vs Leukemia EffectHematopoiesisImmunologic MemoryLymphocytesLymphocytic ChoriomeningitisLymphocytic choriomeningitis virusMiceMice, Inbred C3HMice, Inbred C57BLMice, KnockoutMinor Histocompatibility AntigensT-LymphocytesTissue DonorsTransplantation ImmunologyUp-RegulationVaccinationConceptsDonor T cellsMemory T cellsImmune reconstitutionT cellsAllogeneic hematopoietic stem cell transplantationSingle minor histocompatibility antigenHematopoietic stem cell transplantationVirus-immune donorsLeukemia cellsStem cell transplantationMinor histocompatibility antigensT-cell manipulationChronic myeloid leukemiaLymphocytic choriomeningitis virusGVL effectLeukemia relapseAdoptive immunotherapyMinor histocompatibilityTreatment failureCell transplantationMyeloid leukemiaHistocompatibility antigensGVHDVaccinationInfectionGraft-versus-Leukemia (GVL) against Mouse Blast-Crisis Chronic Myelogenous Leukemia (BC-CML) and Chronic-Phase Chronic Myelogenous Leukemia (CP-CML): Shared Mechanisms of T Cell Killing, but Programmed Death Ligands Render CP-CML and Not BC-CML GVL Resistant
Matte-Martone C, Venkatesan S, Tan HS, Athanasiadis I, Chang J, Pavisic J, Shlomchik WD. Graft-versus-Leukemia (GVL) against Mouse Blast-Crisis Chronic Myelogenous Leukemia (BC-CML) and Chronic-Phase Chronic Myelogenous Leukemia (CP-CML): Shared Mechanisms of T Cell Killing, but Programmed Death Ligands Render CP-CML and Not BC-CML GVL Resistant. The Journal Of Immunology 2011, 187: 1653-1663. PMID: 21768400, PMCID: PMC3150287, DOI: 10.4049/jimmunol.1100311.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsMeSH KeywordsAnimalsApoptosis Regulatory ProteinsBlast CrisisGenes, ablGraft vs Leukemia EffectHomeodomain ProteinsHumansLeukemia, Myelogenous, Chronic, BCR-ABL PositiveMiceMice, Inbred BALB CMice, KnockoutNuclear Pore Complex ProteinsOncogene Proteins, FusionRetroviridaeT-LymphocytesTransduction, GeneticConceptsChronic myelogenous leukemiaChronic phase chronic myelogenous leukemiaT cell killingBlast crisis chronic myelogenous leukemiaMyelogenous leukemiaBC-CMLCP-CMLPD-L1/L2Cell killingTNFR1/R2Donor T cellsT cell targetingGene-deficient miceTCR-MHC interactionsT cell recognitionTypes of leukemiaCell-intrinsic mechanismsDeath-1Leukemia burdenAcute leukemiaT cellsICAM-1Bone marrowMHC moleculesLeukemiaGraft-versus-Host Disease Is Independent of Innate Signaling Pathways Triggered by Pathogens in Host Hematopoietic Cells
Li H, Matte-Martone C, Tan HS, Venkatesan S, McNiff J, Demetris AJ, Jain D, Lakkis F, Rothstein D, Shlomchik WD. Graft-versus-Host Disease Is Independent of Innate Signaling Pathways Triggered by Pathogens in Host Hematopoietic Cells. The Journal Of Immunology 2011, 186: 230-241. PMID: 21098219, PMCID: PMC5822434, DOI: 10.4049/jimmunol.1002965.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsT cell responsesHost APCsHost diseaseAPC maturationT cellsAllogeneic hematopoietic stem cell transplantationAlloreactive donor T cellsCell responsesAdaptive T cell responsesHematopoietic stem cell transplantationHost hematopoietic cellsHost IL-12Donor T cellsAlloreactive T cellsStem cell transplantationT cell productionType I IFNInnate signaling pathwaysPattern recognition receptorsHematopoietic cellsMyD88/IL-12Cell transplantationIL-1βInflammatory cytokines
2010
Langerhans cells are not required for graft-versus-host disease
Li H, Kaplan DH, Matte-Martone C, Tan HS, Venkatesan S, Johnson K, Demetris AJ, McNiff J, Shlomchik MJ, Shlomchik WD. Langerhans cells are not required for graft-versus-host disease. Blood 2010, 117: 697-707. PMID: 20944073, PMCID: PMC3031488, DOI: 10.1182/blood-2010-07-299073.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsAntigen-presenting cellsDonor T cellsDonor Langerhans cellsLangerhans cellsT cellsAPC subsetsHost diseaseMajor histocompatibility complex-mismatched modelAlloreactive donor T cellsHost Langerhans cellsDiphtheria toxin AGVHD preventionSkin GVHDControl miceVirtue of expressionToxin AGVHDBone marrowCD8CD4EngraftmentGraftWild-type hostsDiseaseMice
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