Sreya Das, PhD
Associate Research ScientistAbout
Research
Publications
2026
Dual recruitment of two CCM2 molecules to KRIT1 suppresses KLF4 expression
Huet-Calderwood C, Fisher O, Das S, Su V, Boggon T, Calderwood D. Dual recruitment of two CCM2 molecules to KRIT1 suppresses KLF4 expression. Nature Communications 2026, 17: 2719. PMID: 41688454, PMCID: PMC13013565, DOI: 10.1038/s41467-026-69595-7.Peer-Reviewed Original ResearchThis study investigates how two CCM2 proteins must bind a single KRIT1 protein to regulate KLF4 expression, a process critical for vascular health.
2025
Genetic and oncogenic features of RASGRF fusions
Das S, Lenchner D, Jaeger E, Hunihan L, DeSantis D, Fragkogianni S, Ronski K, Wilson F. Genetic and oncogenic features of RASGRF fusions. Npj Precision Oncology 2025, 9: 224. PMID: 40615519, PMCID: PMC12227644, DOI: 10.1038/s41698-025-01017-1.Peer-Reviewed Original Research
2021
IL-9 Abrogates the Metastatic Potential of Breast Cancer by Controlling Extracellular Matrix Remodeling and Cellular Contractility.
Das S, Surve V, Marathe S, Wad S, Karulkar A, Srinivasan S, Dwivedi A, Barthel S, Purwar R. IL-9 Abrogates the Metastatic Potential of Breast Cancer by Controlling Extracellular Matrix Remodeling and Cellular Contractility. The Journal Of Immunology 2021, 206: 2740-2752. PMID: 34021045, DOI: 10.4049/jimmunol.2000383.Peer-Reviewed Original ResearchMultiomics Analysis and Systems Biology Integration Identifies the Roles of IL-9 in Keratinocyte Metabolic Reprogramming
Marathe S, Dhamija B, Kumar S, Jain N, Ghosh S, Dharikar J, Srinivasan S, Das S, Sawant A, Desai S, Khan F, Syiemlieh A, Munde M, Nayak C, Gandhi M, Kumar A, Srivastava S, Venkatesh K, Barthel S, Purwar R. Multiomics Analysis and Systems Biology Integration Identifies the Roles of IL-9 in Keratinocyte Metabolic Reprogramming. Journal Of Investigative Dermatology 2021, 141: 1932-1942. PMID: 33667432, DOI: 10.1016/j.jid.2021.02.013.Peer-Reviewed Original Research
2019
Blockade of ROCK inhibits migration of human primary keratinocytes and malignant epithelial skin cells by regulating actomyosin contractility
Srinivasan S, Das S, Surve V, Srivastava A, Kumar S, Jain N, Sawant A, Nayak C, Purwar R. Blockade of ROCK inhibits migration of human primary keratinocytes and malignant epithelial skin cells by regulating actomyosin contractility. Scientific Reports 2019, 9: 19930. PMID: 31882703, PMCID: PMC6934852, DOI: 10.1038/s41598-019-56447-2.Peer-Reviewed Original ResearchHydrogel scaffold with substrate elasticity mimicking physiological-niche promotes proliferation of functional keratinocytes
Mogha P, Srivastava A, Kumar S, Das S, Kureel S, Dwivedi A, Karulkar A, Jain N, Sawant A, Nayak C, Majumder A, Purwar R. Hydrogel scaffold with substrate elasticity mimicking physiological-niche promotes proliferation of functional keratinocytes. RSC Advances 2019, 9: 10174-10183. PMID: 31304009, PMCID: PMC6592153, DOI: 10.1039/c9ra00781d.Peer-Reviewed Original ResearchDifferential Influence of IL-9 and IL-17 on Actin Cytoskeleton Regulates the Migration Potential of Human Keratinocytes
Das S, Srinivasan S, Srivastava A, Kumar S, Das G, Das S, Dwivedi A, Karulkar A, Makkad K, Bilala R, Gupta A, Sawant A, Nayak C, Tayalia P, Purwar R. Differential Influence of IL-9 and IL-17 on Actin Cytoskeleton Regulates the Migration Potential of Human Keratinocytes. The Journal Of Immunology 2019, 202: 1949-1961. PMID: 30760620, DOI: 10.4049/jimmunol.1800823.Peer-Reviewed Original Research
2017
Blockade of Rho-associated protein kinase (ROCK) inhibits the contractility and invasion potential of cancer stem like cells
Srinivasan S, Ashok V, Mohanty S, Das A, Das S, Kumar S, Sen S, Purwar R. Blockade of Rho-associated protein kinase (ROCK) inhibits the contractility and invasion potential of cancer stem like cells. Oncotarget 2017, 5: 21418-21428. PMID: 28199964, PMCID: PMC5400594, DOI: 10.18632/oncotarget.15248.Peer-Reviewed Original Research
2015
Reversible induction of translational isoforms of p53 in glucose deprivation
Khan D, Katoch A, Das A, Sharathchandra A, Lal R, Roy P, Das S, Chattopadhyay S, Das S. Reversible induction of translational isoforms of p53 in glucose deprivation. Cell Death & Differentiation 2015, 22: 1203-1218. PMID: 25721046, PMCID: PMC4572868, DOI: 10.1038/cdd.2014.220.Peer-Reviewed Original Research
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