Sinan Guloksuz, MD, PhD
About
Research
Publications
2025
Exposome-Wide Gene-By-Environment Interaction Study of Psychotic Experiences in the UK Biobank
Lin B, Pries L, Arias-Magnasco A, Klingenberg B, Linden D, Blokland G, van der Meer D, Luykx J, Rutten B, Guloksuz S. Exposome-Wide Gene-By-Environment Interaction Study of Psychotic Experiences in the UK Biobank. Biological Psychiatry Global Open Science 2025, 5: 100460. DOI: 10.1016/j.bpsgos.2025.100460.Peer-Reviewed Original ResearchGene-by-environment interactionsPRS-SCZUK BiobankExposome-wide association studyPsychotic experiencesPolygenic risk scoresAssociated with psychotic experiencesMental distressRisk scoreAssociation studiesSleep problemsBiobankAdditive interactionPsychosis riskAgnostic analysisCorrelation testXWASGenetic vulnerabilityDistressParticipantsScoresCorrelation analysisExposureStudyRiskIndependent and joint effects of genomic and exposomic loads for schizophrenia on psychotic experiences in adolescents of European ancestry
Di Vincenzo M, Prachason T, Sampogna G, Arias-Magnasco A, Lin B, Pries L, van Os J, Rutten B, Barzilay R, Fiorillo A, Guloksuz S. Independent and joint effects of genomic and exposomic loads for schizophrenia on psychotic experiences in adolescents of European ancestry. Schizophrenia 2025, 11: 26. PMID: 39984505, PMCID: PMC11845623, DOI: 10.1038/s41537-025-00569-2.Peer-Reviewed Original ResearchRisk due to interactionDistressing psychotic experiencesExcess risk due to interactionPsychotic experiencesEuropean ancestryMultilevel logistic regression modelsPolygenic risk scoresAdditive interactionStrength of associationLogistic regression modelsEarly adolescenceJoint associationsExposome scoreIncreasing strength of associationSecondary outcomesRisk scorePrimary outcomeRegression modelsStudy dataAdolescent brainSchizophreniaAdolescentsFollow-upJoint effectsOutcomesInternational perspectives on physician knowledge, attitudes, and practices related to medical cannabis
Syed S, Singh J, Elkholy H, Palavra I, Tomicevic M, Eric A, da Costa M, Guloksuz S, Radhakrishnan R. International perspectives on physician knowledge, attitudes, and practices related to medical cannabis. Frontiers In Public Health 2025, 13: 1463871. PMID: 40051509, PMCID: PMC11882600, DOI: 10.3389/fpubh.2025.1463871.Peer-Reviewed Original ResearchConceptsPhysicians' knowledgeStrength of evidenceMedical cannabisCross-sectional survey of physiciansSurvey of physiciansCross-sectional surveyYears of clinical experienceNegative health outcomesCannabis useClinical experienceRefractory chronic neuropathic painClinical decision-makingHealth outcomesPhysicians' attitudesPhysicians' willingnessChronic neuropathic painMedical use of cannabisRisk of psychosisDaily cannabis useMedication useDescriptive statisticsRisk of addictionMedical indicationsUse of cannabisPhysiciansMapping the exposome of mental health: exposome-wide association study of mental health outcomes among UK Biobank participants
Arias-Magnasco A, Lin B, Pries L, Guloksuz S. Mapping the exposome of mental health: exposome-wide association study of mental health outcomes among UK Biobank participants. Psychological Medicine 2025, 55: e16. PMID: 39917825, DOI: 10.1017/s0033291724003015.Peer-Reviewed Original ResearchConceptsMental health phenotypesMental health outcomesExposome-wide association studySymptom dimensionsDiagnostic domainsCommon psychiatric disordersHealth phenotypesHealth outcomesEarly life experiencesMental Health SurveyImproving mental well-beingMental health frameworkAssociation studiesUK Biobank participantsCannabis usePsychiatric disordersEating disordersChildhood adversityPublic health policiesTraumatic eventsMental well-beingMultivariate modelDifferential associationsNeurodevelopmental disordersMental healthNew diagnosis in psychiatry: beyond heuristics
McGorry P, Hickie I, Kotov R, Schmaal L, Wood S, Allan S, Altınbaş K, Boyce N, Bringmann L, Caspi A, Cuthbert B, Gawęda Ł, Groen R, Guloksuz S, Hartmann J, Krueger R, Mei C, Nieman D, Öngür D, Raballo A, Scheffer M, Schreuder M, Shah J, Wigman J, Yuen H, Nelson B. New diagnosis in psychiatry: beyond heuristics. Psychological Medicine 2025, 55: e26. PMID: 39911018, DOI: 10.1017/s003329172400223x.Peer-Reviewed Original ResearchConceptsHierarchical Taxonomy of PsychopathologyMechanisms of mental disordersTaxonomy of PsychopathologyResearch Domain CriteriaTransdiagnostic modelTransdiagnostic researchMental disordersHierarchical taxonomyCategorical approachMental healthRDoCHiTOPPsychiatryNosologyResearch utilizationClinical utilityParadigmPsychopathologyHeuristic modelDSMDisordersIllnessResearchNew diagnosesClinicThe Moderating Role of Genetic and Environmental Risk Factors for Schizophrenia on the Relationship between Autistic Traits and Psychosis Expression in the General Population
Dogan M, Prachason T, Lin B, Pries L, Arias-Magnasco A, Bortoletto R, Menne-Lothmann C, Decoster J, van Winkel R, Collip D, Delespaul P, De Hert M, Derom C, Thiery E, Jacobs N, van Os J, Rutten B, Brondino N, Colizzi M, Luykx J, Fusar-Poli L, Guloksuz S. The Moderating Role of Genetic and Environmental Risk Factors for Schizophrenia on the Relationship between Autistic Traits and Psychosis Expression in the General Population. Schizophrenia Bulletin Open 2025, 6: sgaf005. PMID: 40123716, PMCID: PMC11926675, DOI: 10.1093/schizbullopen/sgaf005.Peer-Reviewed Original ResearchPsychotic experiencesNegative life eventsAutistic traitsLife eventsCommunity Assessment of Psychic ExperiencesAssociated with psychotic experiencesAutism Spectrum QuotientModerating rolePsychosis expressionInteraction effectsPolygenic risk scoresRisk factorsEmotional neglectPsychic ExperiencesPhysical neglectModeration analysisCT subtypesAutism spectrumBonferroni correctionEmotional abuseGenetic overlapMultilevel linear regression modelsTrauma screeningSexual abusePhysical abusePositive associations between mean ambient temperature and involuntary admissions to psychiatric facilities
Joore N, van der Horst M, Noorthoorn E, Strous J, Vruwink F, Guloksuz S, Siegmund P, Luykx J. Positive associations between mean ambient temperature and involuntary admissions to psychiatric facilities. European Psychiatry 2025, 68: e2. PMID: 39791337, PMCID: PMC11795429, DOI: 10.1192/j.eurpsy.2024.1800.Peer-Reviewed Original ResearchConceptsInvoluntary psychiatric admissionsContext of climate changeInvoluntary admissionMean ambient temperatureThin plate regression splinesWeather stationsMeteorological variablesMeteorological dataPsychiatric admissionsClimate changeGeneralized additive modelModeling studiesMental health outcomesPositive association
2024
The Exposome Paradigm: Applications in Psychopathology and Psychopharmacology
Fusar-Poli L, Guloksuz S. The Exposome Paradigm: Applications in Psychopathology and Psychopharmacology. 2024, 337-349. DOI: 10.1007/978-3-031-61992-2_20.Peer-Reviewed Original ResearchES-SCZNonclinical populationsMental disordersResponse to psychopharmacologic treatmentCourse of mental disordersSchizophrenia spectrum disordersPsychopharmacological treatmentClinical psychiatrySpectrum disorderGlobal functioningDevelopmental trajectoriesExposome scoreGeneral populationSchizophreniaEnvironmental risk factorsPsychopathologyPsychopharmacologyDisordersExposome paradigmPsychiatryPhysical outcomesParadigmEnvironmental exposuresPotential utilityClinical characterizationFurther evidence for the association between childhood trauma and suicidal ideation in young individuals: A twin based study
Moreno-Gamazo N, Pries L, Marqués-Feixa L, Papiol S, Romero S, Menne-Lothmann C, Decoster J, van Winkel R, Collip D, Delespaul P, De Hert M, Derom C, Thiery E, Jacobs N, Wichers M, van Os J, Rutten B, Fañanás L, Guloksuz S. Further evidence for the association between childhood trauma and suicidal ideation in young individuals: A twin based study. Journal Of Affective Disorders 2024, 370: 118-123. PMID: 39488234, DOI: 10.1016/j.jad.2024.10.125.Peer-Reviewed Original ResearchChildhood traumaSuicidal ideationPsychiatric evaluation of patientsSCL-90-R.Environmental risk factorsGene-environment correlationHistory of CTSample of twinsTwin analysesGenetic vulnerabilityPsychiatric evaluationRisk factorsTwin studiesTwin pairsPhysical abuseEvaluation of patientsDizygotic twinsGenetic riskIdeationProtective factorsPsychosocial environmentIndividual characteristicsGenetic predispositionIncreased riskTotal CTThe association between aberrant salience and psychotic experiences in general population twins, and genetic vulnerability as a modifier
Drukker M, Todor T, Bongaarts J, Broggi E, Kelkar M, Wigglesworth T, Verhiel K, van Leeuwen K, Koster M, Derom C, Thiery E, De Hert M, Menne-Lothmann C, Decoster J, Collip D, van Winkel R, Jacobs N, Guloksuz S, Rutten B, van Os J. The association between aberrant salience and psychotic experiences in general population twins, and genetic vulnerability as a modifier. BMC Psychiatry 2024, 24: 736. PMID: 39462331, PMCID: PMC11515186, DOI: 10.1186/s12888-024-06176-2.Peer-Reviewed Original ResearchConceptsAberrant salienceGeneral population twinsPsychotic experiencesGenetic vulnerabilityGeneral population samplePsychotic symptomsAssociated with psychotic experiencesUltra-high-risk patientsPositive symptom scalesSubclinical psychotic symptomsWhite noise taskEpisode psychosis patientsAssociated with psychosisPopulation samplePsychosis spectrumPsychosis patientsSymptom ScaleNoise taskSaliencePsychosisSevere endVulnerabilitySymptomsTaskAssociation