Adjunct Faculty
Adjunct faculty typically have an academic or research appointment at another institution and contribute or collaborate with one or more School of Medicine faculty members or programs.
Adjunct rank detailsSinan Guloksuz, MD, PhD
Associate Professor Adjunct in PsychiatryAbout
Research
Publications
2026
Sex differences in the effect of childhood adversity and coping strategies on psychosis expression: A TwinssCan study.
Karaçam Doğan M, Prachason T, Fusar-Poli L, Menne-Lothmann C, Decoster J, van Winkel R, Collip D, Delespaul P, De Hert M, Derom C, Thiery E, Jacobs N, Wichers M, Rutten B, van Os J, Pries L, Guloksuz S. Sex differences in the effect of childhood adversity and coping strategies on psychosis expression: A TwinssCan study. European Psychiatry 2026, 69: e42. PMID: 41714187, DOI: 10.1192/j.eurpsy.2026.10173.Peer-Reviewed Original ResearchConceptsChildhood adversityCoping strategiesSocial supportCommunity assessmentPsychosis expressionCommunity Assessment of Psychic ExperiencesCAPE scoresMixed linear regression analysesUtrecht Coping ListEffects of childhood adversityAdaptive coping strategiesSex-specific effectsEmotional neglectPhysical abuseReassuring thoughtsPhysical neglectSex differencesCoping stylesLinear regression analysisGeneral populationCoping mechanismsEmotional abuseAssociation of PESexual abuseChildhood Trauma QuestionnaireSituating problematic gaming and psychotic-like experiences in the adolescent landscape of affordances: A cohort study
Paquin V, Lavallee Z, Huot-Lavoie M, Ku B, Díaz-Caneja C, Gülöksüz S. Situating problematic gaming and psychotic-like experiences in the adolescent landscape of affordances: A cohort study. Journal Of Behavioral Addictions 2026, 15: 320-331. PMID: 41586822, PMCID: PMC13132357, DOI: 10.1556/2006.2025.00094.Peer-Reviewed Original ResearchPsychotic-like experiencesFamily environmentProtect schoolsFamily environment variablesSchool environmentPositive schoolProblematic gamingSchoolDigital gamesLevels of psychotic-like experiencesPeer environmentAdolescent Brain Cognitive Development StudyAssociated with problematic gamingPeerAffordance theoryCognitive Development StudyLandscape of affordancesAssociated with lower levelsAssociated with higher levelsDevelopment studiesAffordabilityEnvironment variablesYouthPartial supportAntipsychotic plasma concentration as predictor of movement disorders and cardiometabolic side-effects: A comparison with prescription dose
Liu Y, Sommer I, Schoretsanitis G, Hamers I, Scheurink T, Begemann M, Gangadin S, van Beveren N, Consortium H, Sommer I, de Haan L, Veling W, van Os J, Smit F, Begemann M, Koops S, Marcelis M, Kikkert M, van Beveren N, Boonstra N, Rosema B, Bakker P, Gülöksüz S, Lokkerbol J, Wijnen B, Brand B, Gangadin S, van ’t H, Oomen P, Voppel A, de Beer F, Kamphuis S, Hamers I, Djordjevic M, Scheurink T, Noorman J, van Amelsvoort T, Bak M, Berendsen S, van den Brink T, Faber G, Grootens K, de Jonge M, Knegtering H, Kurkamp J, Pijnenborg G, Staring A, Veen N, Veerman S, Wiersma S, Batalla A, Curfs R, Hage J, Graveland E, Hoornaar J, Hobus I, Huizer K, Koops S, Bakker P. Antipsychotic plasma concentration as predictor of movement disorders and cardiometabolic side-effects: A comparison with prescription dose. European Neuropsychopharmacology 2026, 105: 112769. PMID: 41576855, DOI: 10.1016/j.euroneuro.2026.112769.Peer-Reviewed Original ResearchConceptsFirst-episode psychosisCardiometabolic side effectsFirst-episode psychosis patientsBarnes Akathisia Rating ScaleRating ScaleSt. Hans Rating ScaleMovement disordersTherapeutic drug monitoringAntipsychotic plasma concentrationsStriatal dopamine receptorsPrescription dosePlasma concentrationsSide effectsTardive dyskinesiaDopamine receptorsTardive dystoniaWaist circumferenceCardiometabolic indicesMedian 6-month follow-upLongitudinal associationsLow-density-lipoprotein cholesterolDisordersNon-high-density-lipoprotein cholesterolNon-high-density-lipoproteinBody mass indexSex differences in the independent and combined effects of genomic and exposomic risks for schizophrenia on distressing psychotic experiences: insights from the ABCD study
Prachason T, Arias-Magnasco A, Lin B, van Os J, Rutten B, Pries L, Guloksuz S. Sex differences in the independent and combined effects of genomic and exposomic risks for schizophrenia on distressing psychotic experiences: insights from the ABCD study. Archives Of Women's Mental Health 2026, 29: 7. PMID: 41493491, PMCID: PMC12775040, DOI: 10.1007/s00737-025-01644-4.Peer-Reviewed Original ResearchConceptsDistressing psychotic experiencesPsychotic experiencesPRS-SCZES-SCZEarly adolescenceSex differencesCognitive Development StudySex-dependent effectsJoint associationsAssociated with lifetimeAdolescent brainMultilevel logistic regression modelsABCD studyExposome scorePolygenic riskSchizophreniaSex-stratified analysesConclusionThe influenceSex-dependentLogistic regression modelsAdolescentsFollow-up dataGenomic riskSecondary outcomesPE outcomes
2025
Epigenetic biomarkers of inflammation in studies on mental health: Current applications, limitations, and future directions
Schalkwijk W, de Witte L, Gigase F, Cecil C, Suderman M, Gülöksüz S, Rutten B, Boks M. Epigenetic biomarkers of inflammation in studies on mental health: Current applications, limitations, and future directions. Brain Behavior And Immunity 2025, 133: 106245. PMID: 41475675, DOI: 10.1016/j.bbi.2025.106245.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsEpigenome-wide association studiesMental healthDNA methylationMental illnessDNA methylation markersEpigenetic biomarkersBiomarkers of inflammationC-reactive proteinHealth-related outcomesPhysical health outcomesMental health researchMental Health StudyEWAS studiesLevels of DNA methylationMarkers of inflammationLong-term associationHealth linkHealth outcomesHealth StudyHealth researchComprehensive literature reviewDNA methylation biomarkersHealth risk exposureBlood levelsAssociation studiesLongitudinal Prediction of Mental Health Outcomes in Vulnerable Youth using Machine Learning
Pujadas E, Díaz-Caneja C, Stevanovic D, Quintero M, Martín-Isla C, Hernández-González J, Atehortúa A, Lazrak N, Pries L, Delespaul P, Camacho M, Gülöksüz S, Rutten B, Lekadir K. Longitudinal Prediction of Mental Health Outcomes in Vulnerable Youth using Machine Learning. Cognitive Computation 2025, 17: 152. DOI: 10.1007/s12559-025-10509-y.Peer-Reviewed Original ResearchMental health outcomesMental health statusMental distressHealth outcomesHealth statusPredictive of mental health outcomesUK Millennium Cohort StudyMillennium Cohort StudyGeneral mental distressMental illnessEmotional distressModifiable factorsLongitudinal predictionPrevention strategiesVulnerable populationsCohort studyVulnerable young peopleDistressEarly interventionHigh riskBalanced random forest modelVulnerable youthYoung peopleSleep patternsSchool environmentAssociation between the exposome score for schizophrenia and functioning in remitted first-episode psychosis: results from the HAMLETT study
Kamphuis S, Arias-Magnasco A, Gangadin S, Begemann M, Wijnen B, Veling W, de Haan L, Consortium H, Sommer I, van Os J, Bakker P, Gülöksüz S. Association between the exposome score for schizophrenia and functioning in remitted first-episode psychosis: results from the HAMLETT study. Schizophrenia Research 2025, 285: 223-231. PMID: 41056900, DOI: 10.1016/j.schres.2025.09.023.Peer-Reviewed Original ResearchConceptsES-SCZFEP patientsGAF scoresExposome scoreEpisode of psychosisFirst-episode psychosisGlobal assessmentAntipsychotic typeCannabis useSymptomatic remissionAdverse domainsWinter birthEnvironmental risk factorsGAFFunctional impairmentSchizophreniaPsychosisFEPHearing impairmentLiability scoreLinear regression modelsMultiple linear regression modelImpairmentRisk factorsMigrant statusImpact of puberty timing, status and oestradiol on psychotic experiences in the context of exposomic and genomic vulnerability to schizophrenia in female adolescents: longitudinal ABCD study.
Pries L, Prachason T, Arias-Magnasco A, Lin B, Rutten B, Guloksuz S. Impact of puberty timing, status and oestradiol on psychotic experiences in the context of exposomic and genomic vulnerability to schizophrenia in female adolescents: longitudinal ABCD study. The British Journal Of Psychiatry 2025, 1-8. PMID: 40899184, DOI: 10.1192/bjp.2025.36.Peer-Reviewed Original ResearchPsychotic experiencesPRS-SCZES-SCZAssociated with greater likelihoodAdolescent Brain Cognitive Development StudyAssociation of psychotic experiencesDevelopment of psychosisCognitive Development StudyFemale adolescentsPuberty statusNo significant interactionGreater likelihoodPubertal Development ScaleMental health outcomesAnnual follow-up assessmentsFollow-up assessmentAbsence of interactive effectsPsychosis scalesPolygenic risk scoresABCD studySchizophreniaOestradiol concentrationsFemale participantsDevelopment ScalePsychosisMental healthcare expenditure among adults by type of mental healthcare and its association with age and sex in the Netherlands between 2015 and 2020
Dijkstra L, Gülöksüz S, Batalla A, van Os J. Mental healthcare expenditure among adults by type of mental healthcare and its association with age and sex in the Netherlands between 2015 and 2020. PLOS ONE 2025, 20: e0330365. PMID: 40853948, PMCID: PMC12377576, DOI: 10.1371/journal.pone.0330365.Peer-Reviewed Original ResearchConceptsSpecialized mental healthcareMental healthcare expenditureMental healthcare costsMental healthcareHealthcare expendituresHealthcare costsMental health careType of careAge groupsYounger age groupsHealth careAssociated with ageOlder adultsYoung menHealth insuranceCohort studyHealthcareInteraction of ageCareYoung womenWomenLinear regressionSexAgeMenExamining psychological protective mechanisms as moderators of the association between autistic traits and psychosis expression in a general population twin sample
Karaçam Doğan M, Fusar-Poli L, Arias-Magnasco A, Pries L, Lin B, Klingenberg B, Bortoletto R, Colizzi M, Menne-Lothmann C, Decoster J, van Winkel R, Collip D, Delespaul P, De Hert M, Derom C, Thiery E, Jacobs N, van Os J, Rutten B, Luykx J, Prachason T, Guloksuz S. Examining psychological protective mechanisms as moderators of the association between autistic traits and psychosis expression in a general population twin sample. Schizophrenia Research 2025, 284: 133-140. PMID: 40774025, DOI: 10.1016/j.schres.2025.08.003.Peer-Reviewed Original ResearchCommunity Assessment of Psychic ExperiencesPsychosis expressionAutistic traitsOptimal parentingCommunity assessmentCoping stylesMultilevel linear regression modelsPsychosis vulnerabilityRisk factorsGeneral population twin samplePsychological protective factorsRisk of psychosisAutism Spectrum QuotientTotal frequency scoreReassuring thoughtsPsychological protective mechanismsSocial supportLinear regression modelsPrevention strategiesEngagement copingTwin samplePsychic ExperiencesCopingFrequency scoreExtraversion