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Safety Advisor – Team Lead
Biography
Dr. Shumin Bian was trained in biochemistry and biophysics at Ohio
State University before joining Professor Edward Moczydlowski’s lab in
the Pharmacology Department at Yale School of Medicine to study the
mechanisms of calcium activation of BK channels. Now he is a member of
Fred Sigworth’s lab working on the biochemistry of ion channels,
particularly using cryoEM for structure-functional study. He is also
interested in channel-associated proteins and the involvement of ion
channels in signal transduction.
Last Updated on April 07, 2025.
Research
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Research at a Glance
Yale Co-Authors
Frequent collaborators of Shumin Bian's published research.
Publications Timeline
A big-picture view of Shumin Bian's research output by year.
Joseph Santos-Sacchi, PhD
Alberto Rivetta
Former YSMJun-Ping Bai, PhD
Lei Song, MD, PhD
Yangyang Yan
Former YSMYangyu Wu
Former YSM
14Publications
358Citations
Publications
2025
CryoEM structures of Kv1.2 potassium channels, conducting and non-conducting
Wu Y, Yan Y, Yang Y, Bian S, Rivetta A, Allen K, Sigworth F. CryoEM structures of Kv1.2 potassium channels, conducting and non-conducting. ELife 2025, 12: rp89459. PMID: 39945513, PMCID: PMC11825129, DOI: 10.7554/elife.89459.Peer-Reviewed Original ResearchCitationsAltmetricCryoEM structures of Kv1.2 potassium channels, conducting and non-conducting
Wu Y, Yan Y, Yang Y, Bian S, Rivetta A, Allen K, Sigworth F. CryoEM structures of Kv1.2 potassium channels, conducting and non-conducting. ELife 2025, 12 DOI: 10.7554/elife.89459.4.Peer-Reviewed Original ResearchCitations
2017
Current carried by the Slc26 family member prestin does not flow through the transporter pathway
Bai JP, Moeini-Naghani I, Zhong S, Li FY, Bian S, Sigworth FJ, Santos-Sacchi J, Navaratnam D. Current carried by the Slc26 family member prestin does not flow through the transporter pathway. Scientific Reports 2017, 7: 46619. PMID: 28422190, PMCID: PMC5395958, DOI: 10.1038/srep46619.Peer-Reviewed Original ResearchCitations
2013
Real Time Measures of Prestin Charge and Fluorescence during Plasma Membrane Trafficking Reveal Sub-Tetrameric Activity
Bian S, Navaratnam D, Santos-Sacchi J. Real Time Measures of Prestin Charge and Fluorescence during Plasma Membrane Trafficking Reveal Sub-Tetrameric Activity. PLOS ONE 2013, 8: e66078. PMID: 23762468, PMCID: PMC3677934, DOI: 10.1371/journal.pone.0066078.Peer-Reviewed Original ResearchCitations
2012
Expression, Purification and Functional Reconstitution of Slack Sodium-Activated Potassium Channels
Yan Y, Yang Y, Bian S, Sigworth FJ. Expression, Purification and Functional Reconstitution of Slack Sodium-Activated Potassium Channels. The Journal Of Membrane Biology 2012, 245: 667-674. PMID: 22729647, PMCID: PMC3903048, DOI: 10.1007/s00232-012-9425-7.Peer-Reviewed Original ResearchCitations
2011
Interactions between β-Catenin and the HSlo Potassium Channel Regulates HSlo Surface Expression
Bian S, Bai JP, Chapin H, Le Moellic C, Dong H, Caplan M, Sigworth FJ, Navaratnam DS. Interactions between β-Catenin and the HSlo Potassium Channel Regulates HSlo Surface Expression. PLOS ONE 2011, 6: e28264. PMID: 22194818, PMCID: PMC3237428, DOI: 10.1371/journal.pone.0028264.Peer-Reviewed Original ResearchCitationsAltmetricMeSH KeywordsAmino Acid SequenceAnimalsbeta CateninBinding SitesBiological AssayCell MembraneChickensGene Knockdown TechniquesHair Cells, AuditoryHEK293 CellsHumansImmunoprecipitationIntercellular JunctionsKineticsLarge-Conductance Calcium-Activated Potassium Channel alpha SubunitsModels, MolecularMolecular Sequence DataMutant ProteinsMutationPhosphorylationProtein BindingProtein TransportRNA, Small InterferingSequence DeletionTransfectionWnt Signaling PathwayEvaluating Prestin's Changing Biophysical Attributes in Development Using a Tet‐Induced Cell Line
Bian S, Koo B, Kelleher S, Santos-Sacchi J, Navaratnam D, Shera C, Olson E. Evaluating Prestin's Changing Biophysical Attributes in Development Using a Tet‐Induced Cell Line. AIP Conference Proceedings 2011, 1403: 143-147. DOI: 10.1063/1.3658075.Peer-Reviewed Original ResearchCitationsExtracellular chloride regulation of Kv2.1, contributor to the major outward Kv current in mammalian outer hair cells
Li X, Surguchev A, Bian S, Navaratnam D, Santos-Sacchi J. Extracellular chloride regulation of Kv2.1, contributor to the major outward Kv current in mammalian outer hair cells. American Journal Of Physiology - Cell Physiology 2011, 302: c296-c306. PMID: 21940671, PMCID: PMC4054960, DOI: 10.1152/ajpcell.00177.2011.Peer-Reviewed Original ResearchCitations
2010
A highly expressing Tet-inducible cell line recapitulates in situ developmental changes in prestin's Boltzmann characteristics and reveals early maturational events
Bian S, Koo BW, Kelleher S, Santos-Sacchi J, Navaratnam DS. A highly expressing Tet-inducible cell line recapitulates in situ developmental changes in prestin's Boltzmann characteristics and reveals early maturational events. American Journal Of Physiology - Cell Physiology 2010, 299: c828-c835. PMID: 20631244, PMCID: PMC3774197, DOI: 10.1152/ajpcell.00182.2010.Peer-Reviewed Original ResearchCitationsCombinatorial Cysteine Mutagenesis Reveals a Critical Intramonomer Role for Cysteines in Prestin Voltage Sensing
Bai JP, Surguchev A, Bian S, Song L, Santos-Sacchi J, Navaratnam D. Combinatorial Cysteine Mutagenesis Reveals a Critical Intramonomer Role for Cysteines in Prestin Voltage Sensing. Biophysical Journal 2010, 99: 85-94. PMID: 20655836, PMCID: PMC2895379, DOI: 10.1016/j.bpj.2010.03.066.Peer-Reviewed Original ResearchCitations
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