Shefali Chaudhary
Postdoctoral AssociateAbout
Research
Publications
2026
Anxiety modulates odour-linked brain connectivity and alcohol dependence risk
Agarwal K, Chaudhary S, Parma V, Balhara Y, Sarkar S. Anxiety modulates odour-linked brain connectivity and alcohol dependence risk. Brain Communications 2026, 8: fcag096. PMID: 41907314, PMCID: PMC13023364, DOI: 10.1093/braincomms/fcag096.Peer-Reviewed Original ResearchAlcohol use disorderOdor identification scoresNeurobiological modelsAlcohol dependenceBrain connectivityNeurobiological models of addictionAlcohol useCompulsive alcohol useRisky drinkingResting-state functional MRIAlcohol risk groupModels of addictionBrain-behavior interactionsAlcohol-related outcomesIdentification scoresFrontal-parietal connectivityAlcohol dependence riskRisky alcohol useReward circuitTransdiagnostic featureHuman Connectome ProjectDSM scoresUse disorderBrain regionsFunctional MRIAlcohol misuse and negative emotion processing in neurotypical drinkers: Sex differences in behavioral and neural markers
Chaudhary S, Chen Y, Wong H, Chao H, Li C. Alcohol misuse and negative emotion processing in neurotypical drinkers: Sex differences in behavioral and neural markers. Psychiatry Research Neuroimaging 2026, 358: 112174. PMID: 41691915, PMCID: PMC12990894, DOI: 10.1016/j.pscychresns.2026.112174.Peer-Reviewed Original ResearchConceptsNegative emotion processingMiddle frontal gyrusEmotional processingNegative emotionsSex differencesAlcohol misuseProblem drinkingMiddle frontal gyrus activationAssociated with individual differencesBilateral middle frontal gyrusHigher-level cognitive processesPrefrontal cortical activityWhole-brain regressionAlcohol Use Disorders Identification TestAUDIT scoreDisorders Identification TestImpact of negative emotionsFrontal gyrusCommunity sampleIndividual differencesCognitive processesImpact of alcohol misuseNeural markersAlcohol useIdentification TestFunctional inputs to the subgenual cingulate cortex differentiate levels of depressive symptom severity in neurotypical young adults: granger causality and clustering analyses
Li H, Chen Y, Chaudhary S, Ide J, Li C. Functional inputs to the subgenual cingulate cortex differentiate levels of depressive symptom severity in neurotypical young adults: granger causality and clustering analyses. The International Journal Of Neuropsychopharmacology 2026, 29: pyag005. PMID: 41665262, PMCID: PMC12962302, DOI: 10.1093/ijnp/pyag005.Peer-Reviewed Original ResearchConceptsDepressive symptom severityLevels of depressive symptom severityNeurotypical young adultsSymptom severityGranger causality analysisCingulate cortexNeurotypical populationSubgenual anterior cingulate cortexSubgenual cingulate cortexAnterior cingulate cortexAdult Self-ReportYoung adultsScores of depressionHuman Connectome ProjectOrbitofrontal cortexDepressive disorderAnterior insulaComorbid symptomsDepressive traitsFronto-parietalExternalizing problemsSgACCTemporal cortexBrain regionsFunctional connectivity
2025
Morphometric characterization of early- and late-onset Parkinson's disease: An ROI-based study of classification and correlation
Kumari S, Rana B, Chaudhary S, Rajan R, Kumaran S, Srivastava A, Devarajan L. Morphometric characterization of early- and late-onset Parkinson's disease: An ROI-based study of classification and correlation. Neuroscience Informatics 2025, 5: 100228. DOI: 10.1016/j.neuri.2025.100228.Peer-Reviewed Original ResearchLate-onset PDWhite matter volumeGray matter volumeAge-related healthy controlsEarly diagnosisCortical thicknessGyrification indexUPDRS IIIMatter volumeData augmentationParkinson's diseaseClass balanceClassification accuracyCortico-basal ganglia-thalamo-cortical circuitAutomatic diagnosisMachine learningCombined featuresT1-weighted MRICAT12 softwareDiagnosis of PDHealthy controlsClinical variablesAssociated with progressive neurodegenerationEarly diagnosis of PDCorrelation of gray matter volumeNeurobiochemical alterations in patients with idiopathic Parkinson’s disease in sensorimotor cortex using 1H-MRS
Kumari S, Kumaran S, Rajan R, Arora S, Chaudhary S, Srivastava A, Edden R. Neurobiochemical alterations in patients with idiopathic Parkinson’s disease in sensorimotor cortex using 1H-MRS. Neuroscience 2025, 588: 1-10. PMID: 41086931, DOI: 10.1016/j.neuroscience.2025.10.014.Peer-Reviewed Original ResearchConceptsIdiopathic Parkinson's diseaseHealthy controlsUnified Parkinson's Disease Rating ScaleLate-onset PDSensory motor cortexEarly-onset PDCreatine ratioContralateral hemispherePathophysiology of idiopathic Parkinson's diseaseUnified Parkinson's Disease Rating Scale part IProton magnetic resonance spectroscopyTotal N-acetylaspartatePotential in vivo biomarkersIdiopathic Parkinson's disease patientsNo significant group differencesSignificant group differencesTotal UPDRS scoreNeurochemical alterationsParkinson's diseaseN-acetylaspartateClinical severityDisease durationParkinson's Disease Rating ScaleDisease progressionSingle-voxelCingulate and frontopolar cortical projections to the cerebellar vermis support prolonged reaction time in identifying negative emotional scenes in women
Wong H, Chaudhary S, Chen Y, Ide J, Zhang S, Li C. Cingulate and frontopolar cortical projections to the cerebellar vermis support prolonged reaction time in identifying negative emotional scenes in women. NeuroImage 2025, 319: 121435. PMID: 40882825, PMCID: PMC12462808, DOI: 10.1016/j.neuroimage.2025.121435.Peer-Reviewed Original ResearchConceptsGranger causality mappingNegative emotional scenesEmotional scenesIndividual anxietyIdentification of negative emotionsSex differencesReaction timeWhole-brain regressionCerebellar vermisProlonged RTNeutral imagesBehavioral paradigmsAnxiety statesNeural mechanismsBrain regionsNegative emotionsWhole-brainNeural markersAnxietyNeural circuitsAnxiety levelsCerebellar circuitsProlonged reaction timeNeurotypical womenState scoresImaging markers of neuroinflammation in aging and Alzheimer's disease and related dementia: A comprehensive review
Chaudhary S, Chao H, Agarwal K, Gupta S, Li C. Imaging markers of neuroinflammation in aging and Alzheimer's disease and related dementia: A comprehensive review. Neuroscience & Biobehavioral Reviews 2025, 176: 106270. PMID: 40578495, PMCID: PMC12239030, DOI: 10.1016/j.neubiorev.2025.106270.Peer-Reviewed Original ResearchFunctional brain changesBrain changesMagnetic resonance imagingCognitive declineWhite matter deficitsImaging marker of neuroinflammationFunctional brain impairmentAlzheimer's diseaseImpact of neuroinflammationDiffusion tensor imagingMarkers of neuroinflammationFunctional connectivityBrain impairmentAssessment of blood-brain barrierNeural markersBody of researchDevelopment of Alzheimer's diseaseTensor imagingBlood-brain barrierOlder adultsGray matterNeuroinflammatory processesMagnetization transfer imagingStructural imagingRelated dementiaA comparative study of volume and surface changes in early onset Parkinson’s Disease compared to age related controls
Kumari S, Arora S, Chaudhary S, Bhat P, Jaiswal A, Rajan R, Kumaran S, Devarajan L, Srivastava A. A comparative study of volume and surface changes in early onset Parkinson’s Disease compared to age related controls. Proceedings Of The International Society For Magnetic Resonance In Medicine ... Scientific Meeting And Exhibition. 2025 DOI: 10.58530/2025/4896.Peer-Reviewed Original ResearchCortical complexityEarly-onset Parkinson's disease patientsPatterns of brain atrophyBrain atrophyGray matterEarly-onset Parkinson's diseaseHigher medication dosesBrain gray matterParkinson's diseaseGM volumeBrain areasCognitive functionGM atrophyCortical alterationsMotor impairmentMedication dosesHealthy controlsProgressive natureMonitoring of treatmentBrainRelative controlsSevere motor impairmentClinical variablesCortical featuresEarly onset Parkinson's diseasePrediction of alcohol intake patterns with olfactory and gustatory brain connectivity networks
Agarwal K, Chaudhary S, Tomasi D, Volkow N, Joseph P. Prediction of alcohol intake patterns with olfactory and gustatory brain connectivity networks. Neuropsychopharmacology 2025, 50: 1167-1175. PMID: 39962224, PMCID: PMC12089591, DOI: 10.1038/s41386-025-02058-7.Peer-Reviewed Original ResearchVentral attention networkBrain connectivity patternsHuman Connectome ProjectResting-state fMRI dataConnectivity patternsRisk of AUDYoung adultsBrain network connectivityAlcohol intake patternsAlcohol intakeAlcohol consumption behaviorOlfactory perceptionFMRI dataFunctional connectomePast-weekLongitudinal researchAttention networkYoung adult cohortChemosensory cuesBrain connectivity networksConnectome ProjectPast-yearConnectivity networksAlcohol drinkersAlcohol
2024
Drinking severity mediates the relationship between hypothalamic connectivity and rule-breaking/intrusive behavior differently in young women and men: an exploratory study
Li G, Dong Y, Chen Y, Li B, Chaudhary S, Bi J, Sun H, Yang C, Liu Y, Li C. Drinking severity mediates the relationship between hypothalamic connectivity and rule-breaking/intrusive behavior differently in young women and men: an exploratory study. Quantitative Imaging In Medicine And Surgery 2024, 14: 6669683-6666683. PMID: 39281112, PMCID: PMC11400642, DOI: 10.21037/qims-24-815.Peer-Reviewed Original ResearchLeft temporo-parietal junctionHypothalamic connectionsIntrusion scoresParacentral lobuleAlcohol misuseAdult Self-Report ScaleSeverity of alcohol useSeverity of alcohol misuseTemporo-parietal junctionWhole-brain regressionSeverity of drinkingSelf-report scalesHypothalamic functional connectivityImpact of problem drinkingMotivational circuitsDrinking severityHuman Connectome ProjectMotivated behaviorDrinking measuresFunctional connectivityMediation analysisProblem drinkingRule-breakingAlcohol useNeural circuits