Sheng Zhang, PhD
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Psychiatry
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Associate Research Scientist in Psychiatry
Appointments
Psychiatry
Associate Research ScientistPrimary
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Education & Training
- Postdoctoral Associate
- Yale University (2012)
- PhD
- University of Science and Technology of China (2007)
Research
Research at a Glance
Yale Co-Authors
Frequent collaborators of Sheng Zhang's published research.
Publications Timeline
A big-picture view of Sheng Zhang's research output by year.
Chiang-Shan Ray Li, MD, PhD
Carolyn M. Mazure, PhD
Jaime Ide, PhD
Shefali Chaudhary
Ying Chen, MD, PhD
Herta Chao, MD, PhD
16Publications
1,495Citations
Publications
2024
Age-related reduction in anxiety and neural encoding of negative emotional memory
Chaudhary S, Zhang S, Chen Y, Dominguez J, Chao H, Li C. Age-related reduction in anxiety and neural encoding of negative emotional memory. Frontiers In Aging Neuroscience 2024, 16: 1375435. DOI: 10.3389/fnagi.2024.1375435.Peer-Reviewed Original ResearchConceptsNegative emotional memoriesSpielberger State-Trait Anxiety InventoryEmotional memoryAge-related reductionSpielberger State-Trait Anxiety Inventory scoresWhole-brain regressionNegative emotional imagesState-Trait Anxiety InventoryTrait Anxiety InventoryAge-related differencesSignal detection theoryMemory taskNeutral imagesAge-related changesEmotional imagesAnxiety InventoryMediation analysisAnxietyPost-scanCortical activityNeural encodingState scoresMemoryOlder adultsDetection theorySex differences in the effects of individual anxiety state on regional responses to negative emotional scenes
Chaudhary S, Wong H, Chen Y, Zhang S, Li C. Sex differences in the effects of individual anxiety state on regional responses to negative emotional scenes. Biology Of Sex Differences 2024, 15: 15. PMID: 38351045, PMCID: PMC10863151, DOI: 10.1186/s13293-024-00591-6.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsMedial prefrontal cortexState-Trait Anxiety InventoryFunctional magnetic resonance imagingState-Trait Anxiety Inventory scoresSuperior frontal gyrusGeneralized psychophysiological interactionEmotional processingFrontal gyrusLingual gyrusMedial prefrontal cortex connectivityMedial prefrontal cortex activationSex differencesRight inferior frontal gyrusResponse to negative emotionsRight superior frontal gyrusFunctional magnetic resonance imaging dataReaction timeImpact emotional processingNegative emotion processingInferior frontal gyrusLeft parahippocampal gyrusNegative emotional scenesMarkers of anxietyRepeated-measures analysis of covarianceLevels of anxiety
2013
Ventromedial prefrontal cortex and the regulation of physiological arousal
Zhang S, Hu S, Chao HH, Ide JS, Luo X, Farr OM, Li CS. Ventromedial prefrontal cortex and the regulation of physiological arousal. Social Cognitive And Affective Neuroscience 2013, 9: 900-908. PMID: 23620600, PMCID: PMC4090954, DOI: 10.1093/scan/nst064.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsSkin conductance levelVentromedial prefrontal cortexPrefrontal cortexDorsal anterior cingulate cortexCausal roleAnterior cingulate cortexFunctional magnetic resonance imagingMagnetic resonance imagingCerebral blood oxygenationSkin conductance measurementsHealthy adultsPhysiological arousalUnderstanding of dysfunctionCingulate cortexResonance imagingBrain regionsBlood oxygenationAnxiety disordersAltered controlCortexGranger causality analysisSkin conductance responsesBehavioral tasksPhasic skin conductance responsesSkin conductanceError processing and gender-shared and -specific neural predictors of relapse in cocaine dependence
Luo X, Zhang S, Hu S, Bednarski SR, Erdman E, Farr OM, Hong KI, Sinha R, Mazure CM, Li CS. Error processing and gender-shared and -specific neural predictors of relapse in cocaine dependence. Brain 2013, 136: 1231-1244. PMID: 23485852, PMCID: PMC3613717, DOI: 10.1093/brain/awt040.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsDorsal anterior cingulate cortexFunctional magnetic resonance imagingCognitive controlError-related activationError processingCocaine-dependent individualsAnterior cingulate cortexSignal taskCingulate cortexCocaine dependenceFunctional magnetic resonance imaging (fMRI) dataStop-signal taskTreatment-seeking individualsCross-sectional findingsModerate-sized cohortsBrain activationBehavioral treatmentNeural predictorsDrug useMagnetic resonance imaging dataStatistical Parametric Mapping 8Regional activationPsychosocial factorsSuccess trialsMagnetic resonance imaging
2012
Saliency Processing and Obesity: A Preliminary Imaging Study of the Stop Signal Task
Hendrick OM, Luo X, Zhang S, Li C. Saliency Processing and Obesity: A Preliminary Imaging Study of the Stop Signal Task. Obesity 2012, 20: 1796-1802. PMID: 21720427, PMCID: PMC3653271, DOI: 10.1038/oby.2011.180.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsStop-signal taskObese femalesBrain activationCognitive controlAltered cerebral functionSupplementary motor areaSignal taskRegional brain activationInferior parietal cortexSaliency processingCerebral functionLean femalesMotor areaFunctional magnetic resonance imagesParietal cortexSimilar behavioral performanceImaging studiesStop trialsPreliminary imaging studyObesityMagnetic resonance imagesTrialsGreater activationResonance imagesResponse inhibitionCerebral correlates of skin conductance responses in a cognitive task
Zhang S, Hu S, Chao HH, Luo X, Farr OM, Li CS. Cerebral correlates of skin conductance responses in a cognitive task. NeuroImage 2012, 62: 1489-1498. PMID: 22634217, PMCID: PMC3408848, DOI: 10.1016/j.neuroimage.2012.05.036.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsSkin conductance responsesSupplementary motor areaControl of arousalDorsal anterior cingulate cortexAnterior cingulate cortexRegional activationFunctional magnetic resonance imagingMagnetic resonance imagingMedial prefrontal cortexLower skin conductance responsesMotor areaCingulate cortexResonance imagingPrefrontal cortexCerebral correlatesConductance responsesTrialsSuccess trialsNeural activityStop successSignal taskPhysiological arousalCognitive performanceNeural correlatesCortexNeural Processes of an Indirect Analog of Risk Taking in Young Nondependent Adult Alcohol Drinkers—An fMRI Study of the Stop Signal Task
Bednarski SR, Erdman E, Luo X, Zhang S, Hu S, Li C. Neural Processes of an Indirect Analog of Risk Taking in Young Nondependent Adult Alcohol Drinkers—An fMRI Study of the Stop Signal Task. Alcohol Clinical And Experimental Research 2012, 36: 768-779. PMID: 22339607, PMCID: PMC3647608, DOI: 10.1111/j.1530-0277.2011.01672.x.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsStop-signal taskAlcohol useNeural processesSignal taskSocial drinkingRisk takingYoung adult social drinkersFrequency of drinkingAdult social drinkersRight superior frontal gyrusFunctional magnetic resonanceSelf-reported alcohol useSuperior frontal gyrusBrain imaging dataSuperior frontal cortexDangerous alcohol consumptionCognitive factorsNeural correlatesFMRI studyFrontal gyrusSocial drinkersHigh-level drinkingCorresponding effect sizesNumber of drinksNondependent drinkersTask-Related, Low-Frequency Task-Residual, and Resting State Activity in the Default Mode Network Brain Regions
Zhang S, Li CS. Task-Related, Low-Frequency Task-Residual, and Resting State Activity in the Default Mode Network Brain Regions. Frontiers In Psychology 2012, 3: 172. PMID: 22661964, PMCID: PMC3362743, DOI: 10.3389/fpsyg.2012.00172.Peer-Reviewed Original ResearchCitationsConceptsDefault mode networkPosterior cingulate cortexBlood oxygen level-dependent (BOLD) signalLow-frequency fluctuation (fALFF) signalsLevel-dependent signalStop-signal taskCingulate cortexBrain regionsBrain functionTask-related eventsFractional amplitudePrecuneusMode networkDMN regionsSignal taskDMN activityBrain activityCognitive performanceUseful indexLatter findingRestingDMN responseTask eventsTask conditionsFALFF
2011
Functional connectivity mapping of the human precuneus by resting state fMRI
Zhang S, Li CS. Functional connectivity mapping of the human precuneus by resting state fMRI. NeuroImage 2011, 59: 3548-3562. PMID: 22116037, PMCID: PMC3288461, DOI: 10.1016/j.neuroimage.2011.11.023.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsVentral precuneusGreater connectivityDorsal precuneusFrontal gyrusSelf-related processingLess connectivityDorsal anteriorSuperior temporal gyrusMiddle frontal gyrusPosterior parietal cortexDefault mode networkMiddle occipital gyrusOrbital frontal gyrusAnterior cingulate gyrusHippocampus/parahippocampusMental imageryEpisodic memoryCognitive processesPosterior precuneusVisual imageryHuman precuneusFunctional neuroanatomyAngular gyrusTemporal gyrusNegative connectivityDeficits in default mode network activity preceding error in cocaine dependent individuals
Bednarski SR, Zhang S, Hong KI, Sinha R, Rounsaville BJ, Li CS. Deficits in default mode network activity preceding error in cocaine dependent individuals. Drug And Alcohol Dependence 2011, 119: e51-e57. PMID: 21703783, PMCID: PMC3188675, DOI: 10.1016/j.drugalcdep.2011.05.026.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsDefault mode networkCocaine dependenceCocaine useHealthy controlsTask-related cerebral activationBlood oxygenation level-dependent (BOLD) signalDemographics-matched healthy controlsGray matter volumeDefault mode network activityLevel-dependent signalChronic cocaine useRegional brain activationPosterior cingulate cortexStatistical parametric mappingCerebral functionBilateral precuneusCocaine-dependent individualsCerebral activationHealthy peopleMatter volumeCingulate cortexVentromedial prefrontal cortexBrain regionsCognitive deficitsCocaine misuse
Clinical Trials
Current Trials
Thalamus and hypothalamus in cocaine dependence
HIC ID2000023121RolePrincipal InvestigatorPrimary Completion Date03/31/2027Recruiting ParticipantsGenderBothAge18 years - 55 years
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