Sayoko Nishimura, MD, PhD
Associate Research Scientist in NeurosurgeryDownloadHi-Res Photo
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Neurosurgery
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Associate Research Scientist in Neurosurgery
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Neurosurgery
Associate Research ScientistPrimary
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Research at a Glance
Yale Co-Authors
Frequent collaborators of Sayoko Nishimura's published research.
Publications Timeline
A big-picture view of Sayoko Nishimura's research output by year.
Angeliki Louvi, PhD
Murat Günel, MD, FACS, FAHA, FAANS
Kaya Bilguvar, MD, PhD
Ketu Mishra-Gorur, MSc, MS, PhD
4Publications
98Citations
Publications
2018
Cerebrovascular disorders associated with genetic lesions
Karschnia P, Nishimura S, Louvi A. Cerebrovascular disorders associated with genetic lesions. Cellular And Molecular Life Sciences 2018, 76: 283-300. PMID: 30327838, PMCID: PMC6450555, DOI: 10.1007/s00018-018-2934-5.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsCerebrovascular disordersGenetic lesionsCerebral blood flowRational therapeutic approachMolecular mechanismsCerebrovascular diseaseMechanistic understandingTherapeutic approachesBlood flowDisease pathogenesisSporadic formsGenomic findingsCurrent knowledgeGenetic formsDisordersLesionsBlood vessel structureWider implicationsPathogenesisAbnormalitiesDiseaseVessel structure
2017
Combined HMG-COA reductase and prenylation inhibition in treatment of CCM
Nishimura S, Mishra-Gorur K, Park J, Surovtseva YV, Sebti SM, Levchenko A, Louvi A, Gunel M. Combined HMG-COA reductase and prenylation inhibition in treatment of CCM. Proceedings Of The National Academy Of Sciences Of The United States Of America 2017, 114: 5503-5508. PMID: 28500274, PMCID: PMC5448170, DOI: 10.1073/pnas.1702942114.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsMeSH KeywordsAnimalsAstrocytesDiphosphonatesDrosophilaDrug Evaluation, PreclinicalDrug Therapy, CombinationEndothelial CellsFatty Acids, MonounsaturatedFemaleFluvastatinHemangioma, Cavernous, Central Nervous SystemHigh-Throughput Screening AssaysHydroxymethylglutaryl-CoA Reductase InhibitorsImidazolesIndolesMaleMAP Kinase Signaling SystemMicePregnancyProtein PrenylationZoledronic AcidConceptsCerebral cavernous malformationsTreatment of CCMsCommon vascular anomaliesPotential pharmacological treatment optionsFocal neurological deficitsPharmacological treatment optionsCCM diseaseAcute mouse modelCentral nervous systemNeurological deficitsHemorrhagic strokePharmacological therapyLesion burdenVascular deficitsSymptomatic lesionsCombination therapyTreatment optionsVascular anomaliesGlial cellsCavernous malformationsMouse modelPrimary astrocytesNervous systemDrug AdministrationSustained inhibition
2015
Functional Synergy between Cholecystokinin Receptors CCKAR and CCKBR in Mammalian Brain Development
Nishimura S, Bilgüvar K, Ishigame K, Sestan N, Günel M, Louvi A. Functional Synergy between Cholecystokinin Receptors CCKAR and CCKBR in Mammalian Brain Development. PLOS ONE 2015, 10: e0124295. PMID: 25875176, PMCID: PMC4398320, DOI: 10.1371/journal.pone.0124295.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsMeSH KeywordsAnimalsAnimals, NewbornBone Morphogenetic Protein 7Cell MovementChemokine CXCL12CholecystokininCorpus CallosumEmbryo, MammalianGene Expression ProfilingGene Expression Regulation, DevelopmentalHomozygoteHumansInterneuronsMiceMice, KnockoutMidline Thalamic NucleiMutationNeocortexNeuropilin-2Receptor, Cholecystokinin AReceptor, Cholecystokinin BReceptors, N-Methyl-D-AspartateSignal TransductionTranscriptomeConceptsCCK receptorsBrain developmentMammalian neocortical developmentCentral nervous systemCortical interneuron migrationHomozygous mutant miceMammalian brain developmentPeripheral organsReceptor lossCorpus callosumCortical developmentPostnatal brainAbundant neuropeptideNervous systemInterneuron migrationMutant miceEmbryonic neocortexNeocortical developmentReceptorsPeptide hormonesG proteinsCholecystokininReciprocal expressionCCKBRBrain
2014
Ccm3, a gene associated with cerebral cavernous malformations, is required for neuronal migration
Louvi A, Nishimura S, Günel M. Ccm3, a gene associated with cerebral cavernous malformations, is required for neuronal migration. Journal Of Cell Science 2014, 127: e1-e1. DOI: 10.1242/jcs.152207.Peer-Reviewed Original Research
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