Yale researchers may have found a treatment target for a spectrum of genetic disorders that lead to brain malformations, seizures, and intellectual disability.
The Louvi Laboratory
Mechanisms of Brain Morphogenesis and Pathogenesis
Copy Link
Our laboratory is interested in understanding the molecular basis of neurological disease. Utilizing model organisms, patient-derived induced pluripotent stem cells and cerebral organoids, we bridge developmental neuroscience with cell and molecular biology to study the cellular and molecular mechanisms underlying neurovascular and structural brain disorders. We investigate conditions such as primary microcephaly, lissencephaly spectrum disorders, cerebral cavernous malformations, and intracranial aneurysms, aiming to gain insight into fundamental neurodevelopmental processes and to develop targeted therapeutic approaches.
About Angeliki Louvi
Copy Link
Angeliki Louvi is a Professor at Yale School of Medicine, Deputy Director of the MD-PhD Program, and a member of the Yale Program on Neurogenetics and the Interdepartmental Neuroscience Program. She obtained her PhD from the Department of Genetics and Development at Columbia University Irving Medical Center and did post-doctoral work at the École normale supérieure and at the University of Chicago. She came to Yale in 2004.
Principal Investigator
Copy Link