Sam Olyha
she/her/hers
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About
Biography
Sam Olyha is an MD/PhD student in the lab of Dr. Carrie Lucas. Her graduate work explores the role of transcription factor ELF4 in regulating the poising of CD4+ T cells towards an inflammatory state.
Education & Training
- MRes
- University of Oxford, Oncology (2016)
- BS
- Cornell University, Biological Sciences (2014)
Research
Research at a Glance
Yale Co-Authors
Frequent collaborators of Sam Olyha's published research.
Publications Timeline
A big-picture view of Sam Olyha's research output by year.
Andrés S Martin, MD, PhD
Carrie L Lucas, PhD
Liza Konnikova, MD/PhD, FAAP
Saquib A. Lakhani, MD
Thilan Wijesekera, MD, MHS
Xiangyun Yin
5Publications
59Citations
Publications
2024
“Deficiency in ELF4, X-Linked”: a Monogenic Disease Entity Resembling Behçet’s Syndrome and Inflammatory Bowel Disease
Olyha S, O’Connor S, Kribis M, Bucklin M, Uthaya Kumar D, Tyler P, Alam F, Jones K, Sheikha H, Konnikova L, Lakhani S, Montgomery R, Catanzaro J, Du H, DiGiacomo D, Rothermel H, Moran C, Fiedler K, Warner N, Hoppenreijs E, van der Made C, Hoischen A, Olbrich P, Neth O, Rodríguez-Martínez A, Lucena Soto J, van Rossum A, Dalm V, Muise A, Lucas C. “Deficiency in ELF4, X-Linked”: a Monogenic Disease Entity Resembling Behçet’s Syndrome and Inflammatory Bowel Disease. Journal Of Clinical Immunology 2024, 44: 44. PMID: 38231408, PMCID: PMC10929603, DOI: 10.1007/s10875-023-01610-8.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsDEX patientsClass-switched memory B cellsInborn errors of immunityTreated with anti-inflammatory agentsLow natural killerX-linkedMemory B cellsErrors of immunityCohort of patientsIncreased inflammatory cytokinesLoss-of-function variantsHeterogeneous clinical phenotypesInflammatory bowel diseaseTargeted therapeutic interventionsNatural killerAnti-inflammatory agentsAphthous ulcersTherapeutic responseAutoinflammatory syndromeInflammatory markersClinical manifestationsB cellsBehcet's syndromeGastrointestinal symptomsMechanisms of disease
2022
A new tolerogenic cell RORs onto the scene.
Olyha SJ, Eisenbarth SC. A new tolerogenic cell RORs onto the scene. Science Immunology 2022, 7: eadf0767. PMID: 36206352, DOI: 10.1126/sciimmunol.adf0767.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and Concepts
2020
Five Medical Education Podcasts You Need to Know.
Lomayesva NL, Martin AS, Dowley PA, Davies NW, Olyha SJ, Wijesekera TP. Five Medical Education Podcasts You Need to Know. The Yale Journal Of Biology And Medicine 2020, 93: 461-466. PMID: 32874153, PMCID: PMC7448387.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsFlow cytometric identification of T fh 13 cells in mouse and human
Chen JS, Grassmann JDS, Gowthaman U, Olyha SJ, Simoneau T, Berin MC, Eisenbarth SC, Williams A. Flow cytometric identification of T fh 13 cells in mouse and human. Journal Of Allergy And Clinical Immunology 2020, 147: 470-483. PMID: 32709424, PMCID: PMC7854882, DOI: 10.1016/j.jaci.2020.04.063.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsIgE antibodiesHigh affinity IgE antibodiesLife-threatening allergic reactionFollicular helper THigh-affinity IgEIgE productionHelper TAllergic reactionsMast cellsSevere reactionsMouse modelCytometric identificationCellular mechanismsBetter therapeuticsAllergyMiceAntibodiesCellsAnaphylaxisIgEPatientsHumansAeroallergensBasophils
2019
IL-10-Dependent Crosstalk between Murine Marginal Zone B Cells, Macrophages, and CD8α+ Dendritic Cells Promotes Listeria monocytogenes Infection
Liu D, Yin X, Olyha SJ, Nascimento MSL, Chen P, White T, Gowthaman U, Zhang T, Gertie JA, Zhang B, Xu L, Yurieva M, Devine L, Williams A, Eisenbarth SC. IL-10-Dependent Crosstalk between Murine Marginal Zone B Cells, Macrophages, and CD8α+ Dendritic Cells Promotes Listeria monocytogenes Infection. Immunity 2019, 51: 64-76.e7. PMID: 31231033, PMCID: PMC6685086, DOI: 10.1016/j.immuni.2019.05.011.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsListeria monocytogenes infectionB cellsMonocytogenes infectionInducible nitric oxide synthase (iNOS) expressionNitric oxide synthase expressionExchange factor DOCK8Conventional dendritic cellsOxide synthase expressionMarginal zone B cellsMarginal zoneMZ B cellsIntracellular ListeriaPrime CD8Dendritic cellsIL-10Cell primingInterleukin-10Listeria infectionSynthase expressionWhite pulpCell activationMetallophilic macrophagesBacterial infectionsCD8Infection
Academic Achievements and Community Involvement
honor Marshall Scholarship
International AwardDetails09/15/2014United Kingdom
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