Ryan Cool
Research Assistant 2 HSSAbout
Research
Publications
2025
Neural Signatures of Bipolar Disorder and Psychotropic Medication Effects: A Multimodal PET–MRI Study
Asch R, Fan S, Cool R, Boster S, DellaGioia N, Naganawa M, Nabulsi N, Lacadie C, Pietrzak R, Esterlis I. Neural Signatures of Bipolar Disorder and Psychotropic Medication Effects: A Multimodal PET–MRI Study. Biological Psychiatry 2025 PMID: 41325959, DOI: 10.1016/j.biopsych.2025.11.018.Peer-Reviewed Original ResearchGray matter volumeBipolar disorderMedication effectsNeural signaturesPsychotropic medicationsFronto-limbic brain regionsAssociated with greater impulsivityPositron emission tomographyC]UCB-J positron emission tomographyNeurobiology of bipolar disorderSynaptic densitySynaptic vesicle glycoprotein 2AIllness-related changesMatter volumeSV2A densityBD individualsBrain regionsFunctional MRIBrain structuresGroup differencesSynaptic deficitsNeuroimaging findingsPET-MRI studiesMedical statusIn vivo evidenceEffects of Age and BMI on Histamine H3 Receptor Availability in Healthy Humans
Yang Y, Ibrahim W, Gravel P, Pittman B, Hoye J, Cool R, Sadabad F, Zheng M, Pittenger C, Gallezot J, Carson R, Huang H, Radhakrishnan R, Matuskey D. Effects of Age and BMI on Histamine H3 Receptor Availability in Healthy Humans. Molecular Imaging And Biology 2025, 27: 832-838. PMID: 40938339, DOI: 10.1007/s11307-025-02047-8.Peer-Reviewed Original ResearchHigh-resolution research tomographBody mass indexPositron emission tomographyEffects of ageAnterior cingulate cortexPotential confounding effects of ageAge-related declineTwo-tissue compartment modelCingulate cortexReceptor availabilityFrontal cortexParietal cortexOlfactory cortexSubcortical regionsHealthy humansRegional VTCortexConfounding effects of ageCerebellum cortexEmission tomographyTwo-tissueMass indexHealthy individualsInsulaAssessed alterations