Voluntary Faculty
Voluntary faculty are typically clinicians or others who are employed outside of the School but make significant contributions to department programs at the medical center or at affiliate institutions.
Voluntary rank detailsRobert Ostroff, MD
Clinical ProfessorAbout
Research
Publications
2026
Non-inferiority, comparative effectiveness study of intravenous ketamine v. intranasal esketamine for treatment-resistant depression: The EQUIVALENCE trial protocol
Wilkinson S, Prashad S, Dalthorp R, Harding L, Kitay B, Parikh S, Dziura J, Clayton A, Fram G, Lepoutre V, Brown J, Ostroff R, Sanacora G. Non-inferiority, comparative effectiveness study of intravenous ketamine v. intranasal esketamine for treatment-resistant depression: The EQUIVALENCE trial protocol. Contemporary Clinical Trials 2026, 164: 108273. PMID: 41780747, DOI: 10.1016/j.cct.2026.108273.Peer-Reviewed Original ResearchQuick Inventory of Depressive SymptomatologyTreatment-resistant depressionIntranasal esketamineInventory of Depressive SymptomatologyIV ketamineS-enantiomer of ketamineRapid-acting antidepressantsIN esketamineAnxious distressAnxiety severityDepression severityDepressive symptomatologyPsychiatric illnessEsketamineComparative effectiveness studiesWeeks of treatmentDepressionNon-inferiorityRemission rateKetamineFDA-approved therapiesNon-inferiority studyPatient-reported outcomesAdjunctive therapyClinical differences
2024
Blood pressure changes during ketamine infusion for the treatment of depression
Ansari M, Pittman B, Tylee D, Ostroff R, Wilkinson S, Nikayin S. Blood pressure changes during ketamine infusion for the treatment of depression. General Hospital Psychiatry 2024, 90: 62-67. PMID: 38991311, DOI: 10.1016/j.genhosppsych.2024.07.001.Peer-Reviewed Original ResearchKetamine infusionBlood pressure changesBlood pressureRetrospective chart review of patientsChart review of patientsMedical history of hypertensionRetrospective chart reviewHistory of hypertensionSignificant blood pressureDiastolic blood pressureTreatment of depressionSevere hypertensionPatient demographicsHypertensive patientsInfusion sessionsMedical historyHypertensive eventsInfusionPatientsKetamineBP surgeCardiovascular monitoringBloodHypertensionPressure changesKetamine vs Electroconvulsive Therapy for Treatment-Resistant Depression
Jha M, Wilkinson S, Krishnan K, Collins K, Sanacora G, Murrough J, Goes F, Altinay M, Aloysi A, Asghar-Ali A, Barnett B, Chang L, Costi S, Malone D, Nikayin S, Nissen S, Ostroff R, Reti I, Wolski K, Wang D, Hu B, Mathew S, Anand A. Ketamine vs Electroconvulsive Therapy for Treatment-Resistant Depression. JAMA Network Open 2024, 7: e2417786. PMID: 38916891, PMCID: PMC11200139, DOI: 10.1001/jamanetworkopen.2024.17786.Peer-Reviewed Original ResearchConceptsTreatment-resistant depressionQIDS-SR16 scoresElectroconvulsive therapy groupElectroconvulsive therapyQIDS-SR16Measure of premorbid intelligencePosttraumatic stress disorder diagnosisTrial of electroconvulsive therapyNonpsychotic depressive episodeImpaired memory recallAssociated with differential improvementStress disorder diagnosisIntravenous ketamineEnd-of-treatment visitInfusion of ketamineMADRS scorePremorbid intelligenceResistant depressionDepressive episodeMeasures mixed-effects modelsFalse discovery rate adjustmentDisorder diagnosisMemory recallSevere depressionDifferential improvement
2023
Ketamine versus ECT for Nonpsychotic Treatment-Resistant Major Depression
Anand A, Mathew S, Sanacora G, Murrough J, Goes F, Altinay M, Aloysi A, Asghar-Ali A, Barnett B, Chang L, Collins K, Costi S, Iqbal S, Jha M, Krishnan K, Malone D, Nikayin S, Nissen S, Ostroff R, Reti I, Wilkinson S, Wolski K, Hu B. Ketamine versus ECT for Nonpsychotic Treatment-Resistant Major Depression. The New England Journal Of Medicine 2023, 388: 2315-2325. PMID: 37224232, DOI: 10.1056/nejmoa2302399.Peer-Reviewed Original ResearchConceptsTreatment-resistant major depressionPatient-reported qualityElectroconvulsive therapyMajor depressionECT groupKetamine groupTreatment phaseMusculoskeletal adverse effectsSubanesthetic intravenous ketamineWeeks of treatmentInitial treatment phaseIntravenous ketamineSecondary outcomesPrimary outcomeNoninferiority marginTrial groupECT clinicsNoninferiority trialPatientsComparative effectivenessKetamineClinical sitesAdverse effectsDepressionThree times
2019
Adjustment of pulse wave parameters to optimize effective ect treatment
Ostroff R, Kitay B. Adjustment of pulse wave parameters to optimize effective ect treatment. Brain Stimulation 2019, 12: 385. DOI: 10.1016/j.brs.2018.12.229.Peer-Reviewed Case Reports and Technical Notes
2018
The Successful Use of Electroconvulsive Therapy in a Patient With Cerebral Aneurysms and a Pituitary Lesion
Kitay B, Katz R, Wilkinson S, Ostroff R. The Successful Use of Electroconvulsive Therapy in a Patient With Cerebral Aneurysms and a Pituitary Lesion. Journal Of Ect 2018, 1. DOI: 10.1097/00124509-900000000-99225.Peer-Reviewed Case Reports and Technical NotesErratum to: Ketamine: A Promising Rapid-Acting Antidepressant
Wilkinson S, Ostroff R, Katz R, Krystal J. Erratum to: Ketamine: A Promising Rapid-Acting Antidepressant. 2018, e1-e1. DOI: 10.1007/978-981-10-6577-4_24.Commentaries, Editorials and LettersThe Use of Electroconvulsive Therapy in Late-Life Psychiatric Disorders
Ostroff R, Katz R. The Use of Electroconvulsive Therapy in Late-Life Psychiatric Disorders. Current Treatment Options In Psychiatry 2018, 5: 228-241. DOI: 10.1007/s40501-018-0144-2.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsUse of ECTElectroconvulsive therapyTreatment of depressionMovement disordersDepressed Elderly (PRIDE) studySevere psychiatric illnessLife-saving treatmentWarrants further investigationProlonging RemissionPharmacologic treatmentGeriatric patientsElderly StudyClinical algorithmDementia syndromesPsychiatric illnessEffective treatmentParkinson's diseaseElderly populationPsychiatric disordersAge groupsTherapyRemissionTreatmentBehavioral dysregulationDisorders
2017
Ketamine: A Promising Rapid-Acting Antidepressant
Wilkinson S, Ostroff R, Katz R, Krystal J. Ketamine: A Promising Rapid-Acting Antidepressant. 2017, 223-239. DOI: 10.1007/978-981-10-6577-4_16.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMood disordersDeficiency hypothesisInitiation of therapyRapid antidepressant effectsRapid acting antidepressantsEvidence-based treatmentsLong-term riskMood disorders researchRelapse prevention strategiesEfficient therapeutic targetMechanism of actionOral antidepressantsAntidepressant effectsGlutamatergic receptorsGlutamatergic systemNovel antidepressantsSingle doseClinical trialsKetamine exposureRelated symptomsLong-term effectsPsychiatric disordersPrevention strategiesTherapeutic targetDrug Administration
2012
When Cardiac Patients Need ECT—Challenges for the Anesthesiologist
Kurup V, Ostroff R. When Cardiac Patients Need ECT—Challenges for the Anesthesiologist. International Anesthesiology Clinics 2012, 50: 128-140. PMID: 22481560, DOI: 10.1097/aia.0b013e31824ff57c.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
News
News
- March 09, 2026Source: NBC Connecticut (with Dr. Robert Ostroff)
Feeling SAD? How To Beat the Winter Blues
- January 08, 2026Source: WFSB-TV Channel 3
Health Experts Say Dry January Can Bring Measurable Benefits in Just 31 Days
- December 01, 2025
The Rise of Interventional Psychiatry
- July 14, 2025
Department of Psychiatry Honors Residents, Fellows, Faculty, Staff at 2025 Annual Commencement Ceremonies