Ravi Ranjan, PhD, MB(ASCP)
Cards
About
Research
Publications
2025
Discovery and characterization of an enantioselective family VIII esterase from effluent treatment plant sludge metagenome
Yadav M, Ranjan R, Verma P, Sharma R. Discovery and characterization of an enantioselective family VIII esterase from effluent treatment plant sludge metagenome. Scientific Reports 2025, 16: 252. PMID: 41326588, PMCID: PMC12770603, DOI: 10.1038/s41598-025-29625-8.Peer-Reviewed Original ResearchConceptsFamily VIII esterasesP-nitrophenyl estersAmino acid sequence similarityDiscovery of novel enzymesSubstrate specificity profileMetagenomic libraryCaulobacter speciesSequence similarityNovel esterasesSignal peptideNovel enzymesFamily VIIIIndustrial biotechnologyBiochemical characterizationSludge metagenomesFunctional screeningPrimary structureSpecificity profileSerine hydrolasesAmino acidsP-nitrophenylEsteraseAminoEnzymeMethyl mandelateHeterogeneity of CD8αα intraepithelial lymphocytes is transcriptionally conserved between TCRαβ and TCRγδ cell lineages
Hioki K, Liang X, Lynch A, Ranjan R, Pobezinskaya E, Pobezinsky L. Heterogeneity of CD8αα intraepithelial lymphocytes is transcriptionally conserved between TCRαβ and TCRγδ cell lineages. Frontiers In Immunology 2025, 16: 1637209. PMID: 40837586, PMCID: PMC12361183, DOI: 10.3389/fimmu.2025.1637209.Peer-Reviewed Original ResearchConceptsIntestinal intraepithelial lymphocytesEffector-like cellsFunctional specializationMemory-likeFunctional diversityTranscriptional analysisFunctional heterogeneityIntraepithelial lymphocytesGut immunityRegulatory roleDevelopmental pathwaysCell lineagesFunctional rolePopulations of immune cellsMemory-like populationLineagesTCRabGutIEL subsetsEffector-likeImmune cellsCellsImmune responsePrecursor populationLymphocytesHeat treatment activates futile calcium cycling in brown adipose tissue to modulate energy metabolism and alters gut microbiota in C57BL/6 mice
Fan R, Story G, Kim J, Li Z, Bannon S, Cho H, Ranjan R, Kim Y, Layec G, Chung S. Heat treatment activates futile calcium cycling in brown adipose tissue to modulate energy metabolism and alters gut microbiota in C57BL/6 mice. Acta Physiologica 2025, 241: e70025. PMID: 40071450, DOI: 10.1111/apha.70025.Peer-Reviewed Original ResearchConceptsFemale C57BL/6 miceC57BL/6 miceCalcium cyclingAdipose tissueMitigation of tissue damageGut microbiotaMetabolic healthSerum lactate dehydrogenase levelsHuman brown adipocytesHigh-fatHigh-fat (HF) dietRisk of metabolic diseasesLactate dehydrogenase levelsWhole-body HTBrown adipocytesModulation of gut microbiotaMetabolic slowdownLipid metabolism transcriptsDehydrogenase levelsPump expressionEnergy metabolismMetabolic effectsMetabolic benefitsInsulin sensitivityMetabolic changesSingle-cell RNA sequencing reveals tissue-specific transcriptomic changes induced by perfluorooctanesulfonic acid (PFOS) in larval zebrafish (Danio rerio)
Satbhai K, Marques E, Ranjan R, Timme-Laragy A. Single-cell RNA sequencing reveals tissue-specific transcriptomic changes induced by perfluorooctanesulfonic acid (PFOS) in larval zebrafish (Danio rerio). Journal Of Hazardous Materials 2025, 489: 137515. PMID: 39947082, PMCID: PMC12038816, DOI: 10.1016/j.jhazmat.2025.137515.Peer-Reviewed Original ResearchConceptsTissue-specific transcriptomic changesSingle-cell RNA sequencingRNA sequencingTranscriptomic changesMolecular mechanismsPathway-specific genesDanio rerioNotch signaling pathwaySignificant DEGsDNA methylationExpressed genesEpigenetic modificationsSignaling pathwayDevelopmental processesPPAR pathwayGenesPathwayDEGsFatty acidsPost-fertilizationNFE2L2 pathwayPseudo-bulkZebrafishSpecific tissuesHepatocyte clusters
2024
Tubulin sequence divergence is associated with the use of distinct microtubule regulators
Kennard A, Velle K, Ranjan R, Schulz D, Fritz-Laylin L. Tubulin sequence divergence is associated with the use of distinct microtubule regulators. Current Biology 2024, 35: 233-248.e8. PMID: 39694029, PMCID: PMC11753955, DOI: 10.1016/j.cub.2024.11.022.Peer-Reviewed Original ResearchConceptsMicrotubule-binding proteinMicrotubule networkMicrotubule regulationDivergent residuesTranscriptional profilesDeep evolutionary timescalesBinding sitesSequence divergenceGenomic contextGenetic separationEukaryotic cellsSequence diversificationBinding partnersTubulin genesEvolutionary timescalesMitotic spindleBinding proteinMicrotubulesTubulinSpecialized functionsNaegleriaProteinMitotic tubulinDiversificationRegulationSeasonal effects of long-term warming on ecosystem function and bacterial diversity
Shinfuku M, Domeignoz-Horta L, Choudoir M, Frey S, Mitchell M, Ranjan R, DeAngelis K. Seasonal effects of long-term warming on ecosystem function and bacterial diversity. PLOS ONE 2024, 19: e0311364. PMID: 39446706, PMCID: PMC11500971, DOI: 10.1371/journal.pone.0311364.Peer-Reviewed Original ResearchConceptsBacterial diversityEcosystem functionWarming durationHarvard Forest Long-term Ecological ResearchWarming experimentBacterial evennessLong‐term soil warming experimentSoil warming experimentLong Term Ecological ResearchEffects of long-term warmingSeasonal effectsBacterial community diversityEffects of warmingNutrient poolsWarming plotsSoil biodiversityOrganic horizonsLong-term warmingAutumn samplesSoil horizonsBacterial community evennessSoilCommunity diversityCommunity evennessSeasonPatterning ganglionic eminences in developing human brain organoids using a morphogen-gradient-inducing device
Pavon N, Diep K, Yang F, Sebastian R, Martinez-Martin B, Ranjan R, Sun Y, Pak C. Patterning ganglionic eminences in developing human brain organoids using a morphogen-gradient-inducing device. Cell Reports Methods 2024, 4: 100689. PMID: 38228151, PMCID: PMC10831957, DOI: 10.1016/j.crmeth.2023.100689.Peer-Reviewed Original ResearchRespiratory Microbiome
Korkmaz Ü, Cetiner O, Rani A, Ranjan R, Öztürk A. Respiratory Microbiome. Comprehensive ENT 2024, 97-112. DOI: 10.1007/978-3-031-74853-0_8.Peer-Reviewed Original ResearchAirway diseaseMicrobiota-based approachesRespiratory microbiotaRespiratory microbiomeProgression of airway diseaseResponse to treatmentGene sequencing technologyPeriods of exacerbationSeverity of diseaseSequencing technologiesField of proteomicsClinical outcomesCellular functionsClinical symptomsLung diseaseDisease susceptibilityMicrobiotaMicrobiomeInflammatory signalingModulatory roleRoutine useAirwayRespiratory medicineDisease severityPathophysiological processes
2023
Dietary exposure to the food preservative tert-Butylhydroquinone (tBHQ) impairs zebrafish (Danio rerio) survival, growth, organ development, and gene expression in Nrf2a-dependent and independent ways
Leonard E, Marques E, Roy M, Conlin S, Ranjan R, Timme-Laragy A. Dietary exposure to the food preservative tert-Butylhydroquinone (tBHQ) impairs zebrafish (Danio rerio) survival, growth, organ development, and gene expression in Nrf2a-dependent and independent ways. Food And Chemical Toxicology 2023, 176: 113788. PMID: 37075880, PMCID: PMC10213143, DOI: 10.1016/j.fct.2023.113788.Peer-Reviewed Original ResearchConceptsDNA-binding domainTert-ButylhydroquinoneOxidative deteriorationGrowth parametersOxidative deterioration of oilsDeterioration of oilGene expressionGenes related to growthRNA-seq analysisOrgan developmentMeat productsControl dietDanio rerioImmune system-related pathwaysRNA-seqJuvenile periodTranscription factor nuclear factor erythroid 2-related factor 2RNA sequencingZebrafish linesImpact growthDietary exposureIndependent mannerDietZebrafishErythroid 2-related factor 2Aqueous Geochemical Controls on the Sestonic Microbial Community in Lakes Michigan and Superior
Rani A, Ranjan R, Bonina S, Izadmehr M, Giesy J, Li A, Sturchio N, Rockne K. Aqueous Geochemical Controls on the Sestonic Microbial Community in Lakes Michigan and Superior. Microorganisms 2023, 11: 504. PMID: 36838469, PMCID: PMC9963676, DOI: 10.3390/microorganisms11020504.Peer-Reviewed Original ResearchHigh-throughput sequencingMicrobial communitiesSequencing of microbial communitiesShannon diversity indexMicrobial community structureN:P ratiosDissolved oxygenCommunity compositionPhyla ActinobacteriaLake SuperiorLake MichiganAmmonia-oxidizing archaeaDiversity indexCommunity structureFunction of water depthGreat LakesN cyclingFreshwater lake systemLaurentian Great LakesGeochemical controlsLake systemWater columnWater depthLakeAbundance
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830 West Campus Drive, Yale Center for Genome Analysis (YCGA)
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