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Priscilla Dannies, PhD

Professor Emeritus of Pharmacology
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Contact Info

Pharmacology

PO Box 208066, 333 Cedar Street

New Haven, CT 06520-8066

United States

About

Titles

Professor Emeritus of Pharmacology

Appointments

Education & Training

PhD
Brandeis University (1971)

Research

Overview

A major unanswered question in endocrinology is how protein hormones are concentrated into secretory granules. We have developed a model system of rat pituitary tumor cells, GH4C1 cells, which have few secretory granules, but can be induced to accumulate many and to store prolactin. We have identified mutants of human prolactin and human growth hormones that can not be stored themselves, and that interfere with the storage or stability of wild-type hormones.

We are investigating why these mutants behave as they do by physical techniques in solution and biochemical methods in cells. Dominant-negative mutants for secretion of hormones have been found in people deficient in growth hormone, vasopressin and amylin. Understanding how mutants of prolactin and growth hormone interfere with synthesis and storage or normal hormones will lead to understanding the mechanisms of these eficiencies as well as answering a basic question in endocrinology.

Medical Subject Headings (MeSH)

Endocrinology; Pharmacology; Prolactin; Vasopressins

Research at a Glance

Yale Co-Authors

Frequent collaborators of Priscilla Dannies's published research.

Publications

2010

2004

2003

2002

Get In Touch

Contacts

Mailing Address

Pharmacology

PO Box 208066, 333 Cedar Street

New Haven, CT 06520-8066

United States