Patrick Demkowicz
Hospital ResidentAbout
Research
Publications
2026
Clonal determinants of organotropism and survival in metastatic uveal melanoma
Jones B, Hammes E, Demkowicz P, Matesva M, Pointdujour-Lim R, Sinard J, Bacchiocchi A, Halaban R, Bosenberg M, Sznol M, Kluger H, Bakhoum M. Clonal determinants of organotropism and survival in metastatic uveal melanoma. Npj Precision Oncology 2026, 10: 68. PMID: 41582235, PMCID: PMC12913882, DOI: 10.1038/s41698-026-01274-8.Peer-Reviewed Original ResearchUveal melanomaLiver metastasesClonality determinationPost-metastatic survivalMetastatic uveal melanomaPatterns of disseminationBAP1 lossExtrahepatic metastasesPrimary tumorIntraocular cancerMetastatic spreadMetastasisMolecular profilingPatient outcomesMelanomaLiverSurvivalIntraocularMonosomyTumorBAP1PatientsCancerOrganotropism
2025
A Tear-Based Approach for Rapid Identification of Bacterial Pathogens in Corneal Ulcers Using Nanopore Sequencing
Dibbs M, Matesva M, Theotoka D, Jayaraj C, Metiku B, Demkowicz P, Heng J, Wang Y, Bakhoum C, Chow J, Bakhoum M. A Tear-Based Approach for Rapid Identification of Bacterial Pathogens in Corneal Ulcers Using Nanopore Sequencing. Translational Vision Science & Technology 2025, 14: 19. PMID: 40244576, PMCID: PMC12013674, DOI: 10.1167/tvst.14.4.19.Peer-Reviewed Original ResearchConceptsCorneal ulcersTear samplesPolymerase chain reactionNanopore sequencingCorneal scrapingsBacterial pathogensTargeted antimicrobial therapyDetection of causative organismsIdentification of bacterial pathogensPolymerase chain reaction amplification of 16S rRNAAmplification of 16S rRNABacterial growthBacterial species identificationContralateral eyeAntimicrobial therapyImprove patient outcomesNext-generation sequencingCausative bacteriaCornealSchirmer stripsCausative organismDetect bacterial pathogensPolymerase chain reaction amplificationTraditional culture methodsCommensal bacteriaAssociations between Blood DNA Methylation and Histopathologic Features in Lupus Nephritis
Demkowicz P, Kavaliauskaite I, Faulkner S, Kent C, Shaw M, Kumar D, Ix J, Wilson F, Moledina D, Bakhoum M, Bakhoum C. Associations between Blood DNA Methylation and Histopathologic Features in Lupus Nephritis. Kidney360 2025, 6: 1404-1408. PMID: 40048255, PMCID: PMC12407129, DOI: 10.34067/kid.0000000758.Peer-Reviewed Original Research
2024
Association between Device Manufacturer Payments to Surgeons and Minimally Invasive Glaucoma Surgery Utilization in the United States
Demkowicz P, Teng C, Liu J, Sarrafpour S. Association between Device Manufacturer Payments to Surgeons and Minimally Invasive Glaucoma Surgery Utilization in the United States. Ophthalmology Glaucoma 2024, 8: 206-208. PMID: 39537114, DOI: 10.1016/j.ogla.2024.11.002.Peer-Reviewed Original ResearchChanges in Facility Share of Medicaid-insured Patients With Urologic Cancers Following Implementation of the Patient Protection and Affordable Care Act
Demkowicz P, Buck M, Nie J, Marks V, Wheeler S, Dinan M, Gross C, Leapman M. Changes in Facility Share of Medicaid-insured Patients With Urologic Cancers Following Implementation of the Patient Protection and Affordable Care Act. Urology 2024, 192: 19-27. PMID: 38901803, DOI: 10.1016/j.urology.2024.06.003.Peer-Reviewed Original ResearchFacility-level changesAffordable Care ActNon-expansion statesUrological cancer patientsProportion of patientsExpansion statesBaseline proportion of patientsUrologic cancer careHigh-income zip codesCancer patientsFactors associated with changesPre-post designCancer care centerPost-ACA periodMedicaid expansion statesMultivariate logistic regressionMedicaid-insured patientsCancer careUrological cancersZip codesCare ActMedicaid patientsMedicaidLogistic regressionCare center
2023
Determinants of overall survival in patients with metastatic uveal melanoma
Demkowicz P, Pointdujour‐Lim R, Miguez S, Lee Y, Jones B, Barker C, Bosenberg M, Abramson D, Shoushtari A, Kluger H, Francis J, Sznol M, Bakhoum M. Determinants of overall survival in patients with metastatic uveal melanoma. Cancer 2023, 129: 3275-3286. PMID: 37382208, PMCID: PMC11149607, DOI: 10.1002/cncr.34927.Peer-Reviewed Original ResearchConceptsAnti-PD-1 therapyMetastatic uveal melanomaDeath hazard ratioImmune checkpoint inhibitorsOverall survivalHazard ratioUveal melanomaSurvival outcomesFemale sexCheckpoint inhibitorsECOG scoreValidation cohortEastern Cooperative Oncology Group performance status scaleGood baseline performance statusMetastatic uveal melanoma patientsMetastatic UM patientsImproved overall survivalMedian overall survivalBaseline performance statusBetter survival outcomesImproved survival outcomesPotential of immunotherapyWorse survival outcomesImmune checkpoint therapyKaplan-Meier analysisPhysician responses to apple watch-detected irregular rhythm alerts
Demkowicz P, Dhruva S, Spatz E, Beatty A, Ross J, Khera R. Physician responses to apple watch-detected irregular rhythm alerts. American Heart Journal 2023, 262: 29-37. PMID: 37084933, PMCID: PMC10988207, DOI: 10.1016/j.ahj.2023.04.008.Peer-Reviewed Original ResearchConceptsAtrial fibrillationPrimary careEmergency medicinePhysician responsesDiagnostic testingUse of antiarrhythmicsClinical practice guidelinesMeasurement of BNPFurther diagnostic testingCase-based surveyLarge academic centerAF alertsAsymptomatic patientsPatient demographicsClinical symptomsTreatment optionsMedical historyPatient referralPhysician specialtyPractice guidelinesPhysician differencesRhythm monitoringAcademic centersUS FoodClinical complexityValidation of the Prognostic Usefulness of the Gene Expression Profiling Test in Patients with Uveal Melanoma
Miguez S, Lee R, Chan A, Demkowicz P, Jones B, Long C, Abramson D, Bosenberg M, Sznol M, Kluger H, Goldbaum M, Francis J, Pointdujour-Lim R, Bakhoum M. Validation of the Prognostic Usefulness of the Gene Expression Profiling Test in Patients with Uveal Melanoma. Ophthalmology 2023, 130: 598-607. PMID: 36739981, PMCID: PMC10619207, DOI: 10.1016/j.ophtha.2023.01.020.Peer-Reviewed Original ResearchConceptsMetastasis-free survivalRisk of metastasisClass 2 tumorsAdditional prognostic valueRate of metastasisPrognostic usefulnessTumor sizeTumor characteristicsPrognostic valueUveal melanomaGene expression profile testingMemorial Sloan-Kettering Cancer CenterGEP classificationCox hazard regression analysisYale-New Haven HospitalHazards regression analysisGene expression profiling testsNew Haven HospitalClass 1 tumorsGEP class 2Class 1AMean followTumor thicknessCancer CenterSurveillance protocol
2022
Racial disparities among older adults with acute myocardial infarction: The SILVER‐AMI study
Demkowicz P, Hajduk A, Dodson J, Oladele C, Chaudhry S. Racial disparities among older adults with acute myocardial infarction: The SILVER‐AMI study. Journal Of The American Geriatrics Society 2022, 71: 474-483. PMID: 36415964, PMCID: PMC9957871, DOI: 10.1111/jgs.18084.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionFunctional impairmentGeriatric conditionsClinical characteristicsMyocardial infarctionBlack participantsOlder adultsRacial disparitiesRisk of mortalityMore functional impairmentSILVER-AMI StudyBlack older adultsYounger average ageUnadjusted oddsDaily livingAMI hospitalizationAverage ageGeriatric phenotypesUS hospitalsHospitalizationLogistic regressionMortalityImpairmentInfarctionUnintentional lossExploratory studies of oral and fecal microbiome in healthy human aging
Zhou X, Wang B, Demkowicz P, Johnson J, Chen Y, Spakowicz D, Zhou Y, Dorsett Y, Chen L, Sodergren E, Kuchel G, Weinstock G. Exploratory studies of oral and fecal microbiome in healthy human aging. Frontiers In Aging 2022, 3: 1002405. PMID: 36338834, PMCID: PMC9631447, DOI: 10.3389/fragi.2022.1002405.Peer-Reviewed Original ResearchHealthy older groupHealthy older adultsFecal microbiomeOlder adultsBody sitesOlder groupCommon chronic diseasesYounger cohortsRibosomal RNA gene sequencingVulnerable older adultsDifferent body sitesFecal microbiome compositionRNA gene sequencingHuman agingHealthy human agingChronic diseasesOlder subjectsHealth statusOral microbiomeMicrobiome changesHealthy agingPredominant bacterial speciesFecal samplesMicrobiome compositionAdults