About
Research
Publications
2026
Interdisciplinary, community-engaged training on endocrine-disrupting chemicals: bridging science, communication, justice and policy for environmental health
Albert R, Honan J, Webb G, Wang L, Tucker J, Shahin S, Medley E, Kauth J, Sempere-Navarro R, Christensen A, Chakraborty D, Johnson L, Delaney P. Interdisciplinary, community-engaged training on endocrine-disrupting chemicals: bridging science, communication, justice and policy for environmental health. Journal Of Environmental Studies And Sciences 2026, 1-13. DOI: 10.1007/s13412-026-01116-w.Peer-Reviewed Original ResearchArsenite methyltransferase 3 is required for mitochondrial function and hepatic lipid metabolism
Delaney P, Griffin J, Khan N, Ibrash B, O'Connor M, Venit T, Ambrosio E, Pergantis S, Ober E, Percipalle P, Sadler K. Arsenite methyltransferase 3 is required for mitochondrial function and hepatic lipid metabolism. The FEBS Journal 2026 PMID: 42068242, DOI: 10.1111/febs.70559.Peer-Reviewed Original ResearchBnip3lb-driven mitophagy maintains fate of the embryonic hematopoietic stem cell pool
Meader E, Walcheck M, Leder M, Delaney P, Falchetti M, Jing R, Li C, Kambli N, Wrighton P, Sugden W, Najia M, Oderberg I, Taylor V, LeBlanc Z, Quenzer E, Lim S, Schlaeger T, Daley G, Goessling W, North T. Bnip3lb-driven mitophagy maintains fate of the embryonic hematopoietic stem cell pool. Nature Communications 2026, 17: 3140. PMID: 41735276, PMCID: PMC13043691, DOI: 10.1038/s41467-026-69593-9.Peer-Reviewed Original ResearchEx vivo functionRegulation of reactive oxygen speciesHematopoietic stem cell poolFunction of HSPCsMyeloid-biased differentiationHuman induced pluripotent stem cellsEndothelial-to-hematopoietic transitionStem cell poolGenetic inductionSpatio-temporal regulationPluripotent stem cellsAdult HSPCsCaudal hematopoietic tissueHSPC numbersHematopoietic stemHematopoietic coloniesProgenitor numbersProliferative expansionProgenitor cellsHSPCsCell poolHematopoietic tissueStem cellsSecondary nichesHSPC specification
2025
Su1682: UNVEILING THE TEMPORAL DYNAMICS OF ZEBRAFISH LIVER REGENERATION FOLLOWING SEVERE ACUTE INJURY: INSIGHTS FROM LIVE IMAGING AND BULK RNA SEQUENCING
Wedig E, Trivedi M, Delaney P, Marcotte S, Goessling W. Su1682: UNVEILING THE TEMPORAL DYNAMICS OF ZEBRAFISH LIVER REGENERATION FOLLOWING SEVERE ACUTE INJURY: INSIGHTS FROM LIVE IMAGING AND BULK RNA SEQUENCING. Gastroenterology 2025, 169: s-1751. DOI: 10.1016/s0016-5085(25)04889-9.Peer-Reviewed Original Research
2024
Sustained effects of developmental exposure to inorganic arsenic on hepatic gsto2 expression and mating success in zebrafish
Koomson A, Delaney P, Khan N, Sadler K. Sustained effects of developmental exposure to inorganic arsenic on hepatic gsto2 expression and mating success in zebrafish. Biology Open 2024, 13: bio060094. PMID: 38446164, PMCID: PMC10941348, DOI: 10.1242/bio.060094.Peer-Reviewed Original ResearchConceptsIAs toxicityInorganic arsenicDevelopmental exposureExposure to inorganic arsenicReproductive successExposure to iAsIAs metabolismMating successImpact of exposureFish healthEnvironmental toxicantsArsenicEffects of IAHepatic transcriptomePost-fertilizationToxicityGSTO2 genesSustained effectExposureIAExposure protocolLong-term survivalFishZebrafish embryosMonths of age
2023
Methods to Study Liver Disease Using Zebrafish Larvae
Magnani E, Nair A, McBain I, Delaney P, Chu J, Sadler K. Methods to Study Liver Disease Using Zebrafish Larvae. Methods In Molecular Biology 2023, 2707: 43-69. PMID: 37668904, DOI: 10.1007/978-1-0716-3401-1_3.Peer-Reviewed Original ResearchConceptsLiver diseaseLiver injuryBiological underpinningsTreatment optionsSelf-resolvingPreneoplastic changesWhole-animal modelAnimal modelsLiver cancerRegenerative capacityFibrosisPotential treatmentFatty liverGene expression analysisLiverDiseaseLiver biologyInjuryZebrafish larvaeCancerTreatmentStaining methodPathologyCellular componentsExpression analysis
2022
Signatures of selection underpinning rapid coral adaptation to the world’s warmest reefs
Smith E, Hazzouri K, Choi J, Delaney P, Al-Kharafi M, Howells E, Aranda M, Burt J. Signatures of selection underpinning rapid coral adaptation to the world’s warmest reefs. Science Advances 2022, 8: eabl7287. PMID: 35020424, PMCID: PMC10954036, DOI: 10.1126/sciadv.abl7287.Peer-Reviewed Original ResearchWarmer reefsCoral populationsPersian/Arabian GulfEvolutionary responsesResponse of coral populationsIndian Ocean reefsSignatures of selectionThermal toleranceElevated thermal toleranceTargets of selectionCoral adaptationPopulation genomicsGenomic lociOceanic reefsGenetic rescueDisruptive selectionGenetic variationCoralsThermal adaptationReefsMarine transgressionGenomeEnvironmental changesDemographic analysisLoci
2021
Systematic Evaluation of the Effects of Toxicant Exposure on Survival in Zebrafish Embryos and Larvae
Nair A, Delaney P, Koomson A, Ranjan S, Sadler K. Systematic Evaluation of the Effects of Toxicant Exposure on Survival in Zebrafish Embryos and Larvae. Current Protocols 2021, 1: e231. PMID: 34491623, DOI: 10.1002/cpz1.231.Peer-Reviewed Original ResearchConceptsAnimal modelsZebrafish embryosLarval maturationToxicological studiesLethal concentrationAnimal densityToxicological thresholdWhole-animal modelLarvaeToxicant exposureVertebrate animal modelDevelopmental stagesSurvival of zebrafish embryosPhysiological responsesStandard protocolGenetic backgroundResponse to toxicant exposure
2020
Arsenic induced redox imbalance triggers the unfolded protein response in the liver of zebrafish
Delaney P, Ramdas Nair A, Palmer C, Khan N, Sadler K. Arsenic induced redox imbalance triggers the unfolded protein response in the liver of zebrafish. Toxicology And Applied Pharmacology 2020, 409: 115307. PMID: 33147493, PMCID: PMC7725916, DOI: 10.1016/j.taap.2020.115307.Peer-Reviewed Original ResearchConceptsUnfolded protein responseCellular stress response pathwaysStress response pathwaysIAs exposureReactive oxygen speciesTranscriptional outputProtein responseEndoplasmic reticulumResponse pathwaysLiver of zebrafishAcute exposureUnfolded protein response activationActivation of genesIAs toxicityInorganic arsenicArsenic toxicityRedox imbalanceReactive oxygen species productionOxidative stress responseGFP tagSecretory proteinsER stressHepatic toxicityUPR activationIA susceptibility
2017
Genetic structure of coral-Symbiodinium symbioses on the world’s warmest reefs
Smith E, Hume B, Delaney P, Wiedenmann J, Burt J. Genetic structure of coral-Symbiodinium symbioses on the world’s warmest reefs. PLOS ONE 2017, 12: e0180169. PMID: 28666005, PMCID: PMC5493405, DOI: 10.1371/journal.pone.0180169.Peer-Reviewed Original ResearchConceptsGenetic structureP. daedaleaBleaching thresholdsGenetic divergenceGulf of OmanCoral-Symbiodinium symbiosesThermal toleranceThermal tolerance traitsSymbiodinium thermophilumWarmer reefsSymbiont communitiesGene flowSymbiotic algaeNuclear markersSymbiont populationsPlatygyra daedaleaITS datasetClade DLocal adaptationCoralsNatural exportReefsC3 variantsTolerance traitsSea temperature