Nina Noa Brodsky, MD
Assistant ProfessorCards
About
Research
Publications
Featured Publications
Immune dysregulation and autoreactivity correlate with disease severity in SARS-CoV-2-associated multisystem inflammatory syndrome in children
Ramaswamy A, Brodsky NN, Sumida TS, Comi M, Asashima H, Hoehn KB, Li N, Liu Y, Shah A, Ravindra NG, Bishai J, Khan A, Lau W, Sellers B, Bansal N, Guerrerio P, Unterman A, Habet V, Rice AJ, Catanzaro J, Chandnani H, Lopez M, Kaminski N, Dela Cruz CS, Tsang JS, Wang Z, Yan X, Kleinstein SH, van Dijk D, Pierce RW, Hafler DA, Lucas CL. Immune dysregulation and autoreactivity correlate with disease severity in SARS-CoV-2-associated multisystem inflammatory syndrome in children. Immunity 2021, 54: 1083-1095.e7. PMID: 33891889, PMCID: PMC8043654, DOI: 10.1016/j.immuni.2021.04.003.Peer-Reviewed Original ResearchCytokinopathy with aberrant cytotoxic lymphocytes and profibrotic myeloid response in SARS-CoV-2 mRNA vaccine–associated myocarditis
Barmada A, Klein J, Ramaswamy A, Brodsky N, Jaycox J, Sheikha H, Jones K, Habet V, Campbell M, Sumida T, Kontorovich A, Bogunovic D, Oliveira C, Steele J, Hall E, Pena-Hernandez M, Monteiro V, Lucas C, Ring A, Omer S, Iwasaki A, Yildirim I, Lucas C. Cytokinopathy with aberrant cytotoxic lymphocytes and profibrotic myeloid response in SARS-CoV-2 mRNA vaccine–associated myocarditis. Science Immunology 2023, 8: eadh3455-eadh3455. PMID: 37146127, PMCID: PMC10468758, DOI: 10.1126/sciimmunol.adh3455.Peer-Reviewed Original ResearchNovel compound heterozygous variants in NHLRC2 in a patient with FINCA syndrome
Brodsky NN, Boyarchuk O, Kovalchuk T, Hariyan T, Rice A, Ji W, Khokha M, Lakhani S, Lucas CL. Novel compound heterozygous variants in NHLRC2 in a patient with FINCA syndrome. Journal Of Human Genetics 2020, 65: 911-915. PMID: 32435055, DOI: 10.1038/s10038-020-0776-0.Peer-Reviewed Original ResearchAmino Acid SequenceAngiomatosisBrain NeoplasmsCardiomegalyChild, PreschoolExome SequencingFibrosisHeterozygoteHumansIntracellular Signaling Peptides and ProteinsLung DiseasesMaleModels, MolecularNeurodegenerative DiseasesPedigreePoint MutationProtein ConformationProtein DomainsSequence AlignmentSequence Homology, Amino AcidSyndromeInfections in activated PI3K delta syndrome (APDS)
Brodsky NN, Lucas CL. Infections in activated PI3K delta syndrome (APDS). Current Opinion In Immunology 2021, 72: 146-157. PMID: 34052541, DOI: 10.1016/j.coi.2021.04.010.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMultisystem Inflammatory Syndrome in Children: Host Immunologic Responses
Mazer M, Bulut Y, Brodsky N, Lam F, Sturgill J, Miles S, Shein S, Carroll C, Remy K, Section O. Multisystem Inflammatory Syndrome in Children: Host Immunologic Responses. Pediatric Critical Care Medicine 2022, 23: 315-320. PMID: 35050932, PMCID: PMC9058188, DOI: 10.1097/pcc.0000000000002897.Peer-Reviewed Original ResearchThe Mystery of MIS-C Post-SARS-CoV-2 Infection
Brodsky NN, Ramaswamy A, Lucas CL. The Mystery of MIS-C Post-SARS-CoV-2 Infection. Trends In Microbiology 2020, 28: 956-958. PMID: 33190685, PMCID: PMC7556780, DOI: 10.1016/j.tim.2020.10.004.Peer-Reviewed Original ResearchEarly-life human CD8+ T cells exhibit rapid, short-lived effector responses and a unique transcription factor landscape
Brodsky N, Chakder M, Kumar D, Barmada A, Wang J, Gu W, Olaloye O, Ramaswamy A, Wats A, Konnikova L, Lucas C. Early-life human CD8+ T cells exhibit rapid, short-lived effector responses and a unique transcription factor landscape. Proceedings Of The National Academy Of Sciences Of The United States Of America 2025, 122: e2421106122. PMID: 40720649, PMCID: PMC12337316, DOI: 10.1073/pnas.2421106122.Peer-Reviewed Original Research
2026
Inflammatory monocytes constrain YAP-induced cell proliferation
Singh S, Tahmasian N, Liu J, Wang W, Haas L, Zhu Y, Griswold M, Brodsky N, Liu S, Kalish B, Yimlamai D. Inflammatory monocytes constrain YAP-induced cell proliferation. Science Advances 2026, 12: eaee8580. PMID: 42341114, PMCID: PMC13292995, DOI: 10.1126/sciadv.aee8580.Peer-Reviewed Original ResearchThis study investigates how YAP and TAZ, key regulators of cell growth, drive opposing immune responses with TAZ promoting tumor growth and YAP being constrained by inflammatory monocytes.Mapping Infant Immunity with Minimal Input: Integrative Single-cell and Multiomic Profiling.
Cao Y, Chakder M, Gawon K, Phan L, Coman M, Oliveira C, Konnikova L, Olaloye O, Brodsky N. Mapping Infant Immunity with Minimal Input: Integrative Single-cell and Multiomic Profiling. Journal Of Visualized Experiments 2026 PMID: 42008512, DOI: 10.3791/70279.Peer-Reviewed Original ResearchReal-world effectiveness of perinatal RSV immunoprophylaxis: protocol for a test-negative case–control study
Llorente C, Wats A, Araujo B, Ganem J, Oliva I, Xu H, Brodsky N, Lucas C, Aronson P, Grubaugh N, Breban M, Redmond S, Shapiro E, Niccolai L, Weinberger D, Oliveira C. Real-world effectiveness of perinatal RSV immunoprophylaxis: protocol for a test-negative case–control study. BMJ Open 2026, 16: e114524. PMID: 41856594, PMCID: PMC13007147, DOI: 10.1136/bmjopen-2025-114524.Peer-Reviewed Original Research
Clinical Care
Overview
Nina Brodsky, MD, is a pediatric critical care specialist who cares for children with serious health issues that require intensive monitoring and support. She focuses on treating conditions such as life-threatening infections, breathing problems, and organ failure using advanced therapies designed to stabilize critically ill children.
Dr. Brodsky uses a range of approaches to help manage the needs of young patients facing complex and rapidly changing conditions. She collaborates with a team of specialists to support vital functions, address underlying causes of illness, and guide families throughout the treatment process.
As an assistant professor of pediatrics at Yale School of Medicine, Dr. Brodsky’s research centers on how genetic and environmental factors affect children who have weakened immune systems or experience harmful inflammation. She aims to uncover targeted therapies that enhance responses to vaccines and infections, while easing excessive immune reactions.
Dr. Brodsky received her medical training from the University of Maryland School of Medicine. She completed her pediatric residency at The Children's Hospital at Montefiore and a fellowship in pediatric critical care at Yale New Haven Hospital.
Clinical Specialties
Board Certifications
Pediatric Critical Care Medicine
- Certification Organization
- AB of Pediatrics
- Original Certification Date
- 2018
Pediatrics
- Certification Organization
- AB of Pediatrics
- Original Certification Date
- 2016
News
News
- September 24, 2025Source: Yale News
‘Primed and Ready’: How One Fast-Acting Type of White Blood Cell Fights Off Infection in Infants
- April 01, 2024Source: The Hartwell Foundation
Nina Brodsky, MD Awarded 2023 Hartwell Individual Biomedical Research Award
- May 05, 2023Source: Stat News
What explains rare heart condition among young men after Covid vaccines? A new study offers clues
- April 13, 2023Source: For Humanity
Breakthroughs at the Bench and Bedside
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