Nicholas Dainiak, MD
About
Research
Publications
2025
Development of Evidence-based Guidelines on Assessment and Management of Internal Contamination with Transuranic Actinides
Li C, Kenbayeva Z, Dainiak N, Yepes-Nuñez J, Zeeb H, Gill S, Akashi M, Alves A, Chang A, DiCarlo A, Iddins C, Kazzi Z, Klumpp J, Osamu K, Lopez M, Phan G, Port M, Riddell A, Salame-Alfie A, Sawant P, Tatsuzaki H, Vassilenko V. Development of Evidence-based Guidelines on Assessment and Management of Internal Contamination with Transuranic Actinides. Disaster Medicine And Public Health Preparedness 2025, 19: e156. PMID: 40538032, DOI: 10.1017/dmp.2025.10091.Peer-Reviewed Original ResearchConceptsGuideline development groupDevelopment of evidence-based guidelinesEvidence-based guidelinesEvidence-based recommendationsWorld Health OrganizationPatient-important health outcomesCare management guidelinesHealth outcomesWorking group meetingsWorld Health Organization protocolSystematic reviewGroup meetingsClinical managementHealth OrganizationContextual factorsManagement guidelinesDevelopment groupQuestion formulationGuidelinesRecommendationsCertainty ratingsResearch question formulationOutcomesEmergency respondersAssessment
2024
Biology of Exfoliation of Plasma Membrane-Derived Vesicles and the Radiation Response: Historical Background, Applications in Biodosimetry and Cell-Free Therapeutics, and Quantal Mechanisms for Their Release and Function with Implications for Space Travel
Dainiak N. Biology of Exfoliation of Plasma Membrane-Derived Vesicles and the Radiation Response: Historical Background, Applications in Biodosimetry and Cell-Free Therapeutics, and Quantal Mechanisms for Their Release and Function with Implications for Space Travel. Radiation Research 2024, 202: 328-354. PMID: 38981604, DOI: 10.1667/rade-24-00078.1.Peer-Reviewed Original ResearchCell-free therapeuticsPlasma membrane-derived vesiclesExtracellular vesiclesExposure to ionizing radiationIndividual radiation dosesMembrane-derived vesiclesExposure to radiationProperties of extracellular vesiclesPathogenesis of diseaseSpace travelDeep spaceRadiation doseInhibitory moleculesSignal traffickingHuman cellsClinical disordersQuantal mechanismRadiation responseMembrane turnoverVesiclesNucleic acidsVesicle surfaceBiophysical propertiesCell-freeRadiation
2016
Inferences, Risk Modeling, and Prediction of Health Effects of Ionizing Radiation
Dainiak N. Inferences, Risk Modeling, and Prediction of Health Effects of Ionizing Radiation. Health Physics 2016, 110: 271-273. PMID: 26808880, DOI: 10.1097/hp.0000000000000465.Peer-Reviewed Original ResearchConceptsSub-threshold doseLow radiation doseAdverse outcomesLow dosesThreshold doseEffects of ionizing radiationRadiation doseClinician's dilemmaDoseAccepted medical practiceIonizing radiationStochastic riskPotential long-termRadiation protection regulationsHealth effects of ionizing radiationRiskRadiation epidemiologistsLaboratory experimentalistsLow/veryRisk model