Na Liu, PhD
Associate Research Scientist in Cell BiologyCards
About
Research
Publications
2025
Effect of hCG day’s estradiol levels on pregnancy outcomes following GnRH antagonist protocol: a retrospective study of 3192 fresh embryo transfer cycles
Zeng H, Chang Y, Liu N, Li S. Effect of hCG day’s estradiol levels on pregnancy outcomes following GnRH antagonist protocol: a retrospective study of 3192 fresh embryo transfer cycles. BMC Pregnancy And Childbirth 2025, 25: 836. PMID: 40797168, PMCID: PMC12341211, DOI: 10.1186/s12884-025-07929-x.Peer-Reviewed Original ResearchPregnancy outcomesAntagonist protocolPregnancy rateHigher pregnancy rateEstradiol levelsRetrospective studyEmbryo transferFresh embryo transfer cyclesEmbryo transfer cyclesFresh embryo transferFresh ET cyclesGnRH antagonist protocolMethodsThe retrospective studyFresh ETHCG dayET cyclesTransfer cyclesXiangya HospitalPregnancyAntagonistOutcomesSegment regressionCPRDoes the weekend matter? evaluating the weekend effect on pregnancy outcomes in first-cycle fresh IVF/ICSI embryo transfers: a retrospective study
Yang T, Yang Y, Hou Z, Chang T, Liu N, Liu D, Li Y, Zhao J, Zhang Q, Yao Z, Tian F, Li Y. Does the weekend matter? evaluating the weekend effect on pregnancy outcomes in first-cycle fresh IVF/ICSI embryo transfers: a retrospective study. BMC Pregnancy And Childbirth 2025, 25: 708. PMID: 40610925, PMCID: PMC12224509, DOI: 10.1186/s12884-025-07783-x.Peer-Reviewed Original ResearchConceptsClinical pregnancy rateDay of oocyte retrievalFresh ET cyclesIntracytoplasmic sperm injectionOocyte retrievalIn vitro fertilizationEmbryo transferAssisted Reproductive TechnologyET cyclesXiangya Hospital of Central South UniversityIVF/ICSI-embryo transferMultivariate logistic regression analysisFresh embryo transferLive birth rateReproductive Medicine CenterRetrospective cohort studyPregnancy success rateLogistic regression analysisCentral South UniversityWeekend groupWeekend retrievalsSperm injectionFresh cyclesPregnancy outcomesRetrospective studyImpact of spring festival on pregnancy outcomes in patients undergoing first embryo transfer: a retrospective cohort study
Yang Y, Hou Z, Qiu H, Chang T, Liu N, Liu D, Li Y, Zhao J, Zhang Q, Yao Z, Tian F, Yang T, Li Y. Impact of spring festival on pregnancy outcomes in patients undergoing first embryo transfer: a retrospective cohort study. Scientific Reports 2025, 15: 23339. PMID: 40604013, PMCID: PMC12222965, DOI: 10.1038/s41598-025-05029-6.Peer-Reviewed Original ResearchConceptsPropensity score matchingRetrospective cohort studyEmbryo transferPregnancy outcomesCohort studyPregnancy rateIn vitro fertilization/intracytoplasmic sperm injectionClinical pregnancy rateFertilization/intracytoplasmic sperm injectionLive birth rateOutcomes of patientsPropensity Score Matching AnalysisMultivariate logistic regressionMultivariate regression analysisUniversity-affiliated hospitalSperm injectionET cyclesImplantation ratePoor prognosisRisk factorsPatientsPregnancyScore matchingBirth rateLogistic regressionEstablishment and application of an RNA-seq-based predictive model for the hourly precision window of implantation (WOI) in patients with recurrent implantation failure
He A, Yang T, Lu S, Zou Y, Wan C, Chen Y, Zhao J, Liu N, Liu D, Li Y, Wang Y, Xu B, Hao J, Fu J, Zhang Q, Wang B, Li Y. Establishment and application of an RNA-seq-based predictive model for the hourly precision window of implantation (WOI) in patients with recurrent implantation failure. Journal Of Assisted Reproduction And Genetics 2025, 42: 2067-2082. PMID: 40304883, PMCID: PMC12229385, DOI: 10.1007/s10815-025-03468-8.Peer-Reviewed Original ResearchRecurrent implantation failureIntrauterine pregnancy ratePersonalized embryo transferLive birth rateImplantation rateB-hCGEndometrial receptivity testPregnancy ratePropensity score matchingImplant failureB-human chorionic gonadotropinEarly spontaneous abortion rateSpontaneous abortion rateControl groupBirth rateIntrauterine pregnancyPregnancy outcomesEndometrial biopsyEmbryo transferChorionic gonadotropinPregnancyPatientsExperimental groupAbortion rateScore matchingMixed reality in medical education: A study on bimanual pelvic examination
Zeng H, Li M, Liu N, Li S. Mixed reality in medical education: A study on bimanual pelvic examination. International Journal Of Gynecology & Obstetrics 2025, 170: 1243-1249. PMID: 40214976, PMCID: PMC12374015, DOI: 10.1002/ijgo.70153.Peer-Reviewed Original ResearchBimanual pelvic examinationPelvic examinationInstructional Materials Motivation SurveyQuality of educationTraditional groupInteractive learning environmentTraditional teaching methodsMixed realityStudent motivationLearning environmentStudent performanceMotivation SurveyTeaching efficiencyTeaching methodsProspective cohort studyMedical studentsStudentsTeachingGynecology educationEducationIncreased engagementGynecological examinationImprove training efficiencyTraining systemXiangya Hospital
2024
Ectopic pregnancy is associated with increased risk of displaced implantation window: a retrospective study
Zeng H, Chang Y, Liu N, Li S. Ectopic pregnancy is associated with increased risk of displaced implantation window: a retrospective study. BMC Pregnancy And Childbirth 2024, 24: 839. PMID: 39707276, PMCID: PMC11661333, DOI: 10.1186/s12884-024-07072-z.Peer-Reviewed Original ResearchConceptsAssisted Reproductive TechnologyBody mass indexAssociated with increased riskPrimary infertilityEmbryo transferEctopic pregnancy historyEctopic pregnancyReproductive Medicine CenterRetrospective studyStatistical significanceGeneralized Estimating EquationsInfertility typeHigher Body Mass IndexReproductive technologySecondary infertilityInfertilityPregnancy historyImplantation windowImplant failureMass indexXiangya HospitalAdvanced ageIncreased riskPatientsPregnancyPersonalized embryo transfer guided by rsERT with hourly precision improves pregnancy outcomes in patients with a receptive window of implantation: a pilot study
Yang T, Hou Z, Zhang Q, Zhao J, Liu N, Liu D, Li Y, Wang Y, Xu B, Zou Y, Wan C, Li Y. Personalized embryo transfer guided by rsERT with hourly precision improves pregnancy outcomes in patients with a receptive window of implantation: a pilot study. Journal Of Assisted Reproduction And Genetics 2024, 41: 2657-2665. PMID: 39254797, PMCID: PMC11534956, DOI: 10.1007/s10815-024-03246-y.Peer-Reviewed Original ResearchIntrauterine pregnancy ratePersonalized embryo transferWindow of implantationEmbryo transferPropensity score matchingImplantation rateET groupCenter for Reproductive MedicineResultsBefore propensity score matchingImplant failure rateGroup compared to controlsRetrospective pilot studyConventional embryo transferMultiple-pregnancy ratesEndometrial receptivity testCentral South UniversityPregnancy outcomesTransferred embryosPilot studyPregnancy ratePatientsSouth UniversityReproductive medicineScore matchingConfounding factorsAssessing vaginal microbiome through Vaginal Microecology Evaluation System as a predictor for in vitro fertilization outcomes: a retrospective study
Tian Q, Jin S, Zhang G, Liu Y, Liu J, Tang X, Li Y, Liu J, Liu Y, Wang Z. Assessing vaginal microbiome through Vaginal Microecology Evaluation System as a predictor for in vitro fertilization outcomes: a retrospective study. Frontiers In Endocrinology 2024, 15: 1380187. PMID: 39045277, PMCID: PMC11263289, DOI: 10.3389/fendo.2024.1380187.Peer-Reviewed Original ResearchControlled ovarian stimulationLive birth rateIVF-ETIVF-ET treatmentVaginal microbiomeBacterial vaginosisPregnancy outcomesEmbryo transferRetrospective analysis of pregnancy outcomesSuccess rate of IVF-ETIn vitro fertilization outcomesAnalysis of pregnancy outcomesFresh embryo transferIVF-ET outcomeEarly miscarriage rateIVF-ET proceduresProportion of patientsMultivariate logistic regression modelBirth rateProcess of in vitro fertilizationMiscarriage rateOvarian stimulationTubal factorPatient ageVaginal microenvironmentMeta‐analysis reveals that rheumatoid arthritis is associated with worse clinical outcomes among patients with COVID‐19
Zhang G, Liu J, Wang J, Wang Z, Zhang J, Ding Y, Tang X, Wang W, Liu J, Liu Y, Liu J, Xu X. Meta‐analysis reveals that rheumatoid arthritis is associated with worse clinical outcomes among patients with COVID‐19. International Journal Of Rheumatic Diseases 2024, 27 DOI: 10.1111/1756-185x.15049.Peer-Reviewed Original ResearchRA patientsClinical outcomesRheumatoid arthritisMeta-analysisAssociated with worse clinical outcomesIncreased risk of adverse clinical outcomesRisk of adverse clinical outcomesAdverse clinical outcomesNon-RA patientsRisk of publication biasSystematic literature searchNo significant differenceCOVID-19 infectionMechanical ventilationClinical severityAdverse outcomesICU admissionIncreased riskVulnerable to coronavirus diseaseEgger's testPatientsElectronic databasesRatings of severityPublication biasCoronavirus disease 2019
2023
A novel homozygous nonsense variant of AK7 is associated with multiple morphological abnormalities of the sperm flagella
Chang T, Tang H, Zhou X, He J, Liu N, Li Y, Xiang W, Yao Z. A novel homozygous nonsense variant of AK7 is associated with multiple morphological abnormalities of the sperm flagella. Reproductive BioMedicine Online 2023, 48: 103765. PMID: 38492416, DOI: 10.1016/j.rbmo.2023.103765.Peer-Reviewed Original ResearchConceptsHomozygous nonsense variantMultiple morphological abnormalitiesWhole-exome sequencingSperm flagellaAssociated with multiple morphological abnormalitiesMitochondrial function of spermatozoaFlagella-associated proteinsFunction of spermatozoaPotential gene variantsMitochondrial metabolic dysfunctionSperm ultrastructureFlagellar assemblyPatient's spermatozoaFlagellar defectsRate of apoptosisConcentration of reactive oxygen speciesMale infertilitySanger sequencingReactive oxygen speciesMitochondrial functionSpermSpermatozoaMutated genesFunctional associationDisease phenotype
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