Mohammad Abdullah Zafar, MBBS
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Associate Research Scientist
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Dr. Mohammad Abdullah Zafar is an Associate Research Scientist, the Research Director, and Yale-Masone Aortic Research Fellow at the Aortic Institute at Yale-New Haven Hospital, Section of Cardiac Surgery, Department of Surgery. The Aortic Institute at Yale-New Haven Hospital is one of the world's largest multidisciplinary clinical and research centers dedicated to the care of patients with thoracic aortic disease. It includes experts in cardiothoracic surgery, cardiology, vascular surgery, vascular radiology, interventional radiology, cardiovascular anesthesiology, bioengineering, epidemiology, molecular genetics, and basic science research in vascular medicine. It is among the first such formally designated centers.
After completing his medical degree with honors and an internship in thoracic surgery in Pakistan, Dr. Zafar joined the Aortic Institute in 2015. Over the past nine years, his research has been focused on advancing the fundamental biomedical understanding of thoracic aortic disease via scientific studies targeted at fostering a better understanding of the natural history and risk prediction, early detection and diagnosis, molecular genetics, and optimal therapies of thoracic aortic disease. Dr. Zafar's work has directly informed the latest U.S. and European Aortic Disease Clinical Practice Guidelines.
As the Aortic Research Fellow and Research Director, Dr. Zafar's role is to bridge the academic, clinical, and research arms of the Aortic Institute to continue to ensure the delivery of state-of-the-art expert and personalized care to aneurysm patients at Yale. Dr. Zafar supervises all investigations at the Institute and leads, mentors, and aids the recruitment of diverse members of the research team that includes high school students, undergraduate students, Yale and visiting medical students, residents, physician associates, postdoctoral fellows, physicians, and surgeons from across the United States and the world. Dr. Zafar has helped establish the Aortic Institute clinical database, tissue bank, and advanced thoracic aortic aneurysm and dissection genetic testing program and database, some of the largest repositories of their kind in the world.
Dr. Zafar has published over one hundred twenty peer-reviewed scientific articles, book chapters, editorials, and commentaries on thoracic aortic disease. He has presented his research work at leading national and international conferences, delivered lectures and Grand Rounds at the Yale School of Medicine, Yale-New Haven Hospital, and other institutions, serves as a peer-reviewer for journals, and serves as an editor for the journal AORTA. Dr. Zafar is completing a Master of Health Science (Clinical Investigation Track) degree from the Yale School of Medicine.
An avid Manchester United fan, Dr. Zafar enjoys playing and watching soccer, strength training, British crime and sci-fi shows, mindful productivity, brunch, and spending time with friends and family.
Appointments
Cardiac Surgery
Associate Research ScientistPrimary
Other Departments & Organizations
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- Cardiac Surgery
- Surgery
Education & Training
- MBBS
- University of Health Sciences (2013)
Research
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Overview
Medical Research Interests
ORCID
0000-0003-1666-199X
Research at a Glance
Yale Co-Authors
Publications Timeline
Research Interests
John Elefteriades, MD
Sandip Mukherjee, MD, FACC
Syed Usman Bin Mahmood, MBBS
Hamid Mojibian, MD
Roland Assi, MD, MMS, FACS, MMSc
Gabe Weininger
Aorta
Cardiac Surgical Procedures
Dissection, Thoracic Aorta
Publications
2026
Association Between JAK2 V617F Somatic Mutation and Thoracic Aortic Aneurysms
Collins S, Zafar M, Elefteriades J. Association Between JAK2 V617F Somatic Mutation and Thoracic Aortic Aneurysms. Genes 2026, 17: 364. DOI: 10.3390/genes17040364.Peer-Reviewed Original ResearchConceptsJAK2 V617F somatic mutationV617F somatic mutationThoracic aortic aneurysmThoracic aortic aneurysm formationAortic aneurysm formationAortic aneurysmJAK2 V617FSomatic mutationsFormation of thoracic aortic aneurysmAneurysm formationThoracic aortic aneurysm developmentAssociated with germline mutationsAortic aneurysm developmentPopulation-based cohort studyPro-inflammatory leukocytesAneurysm growth rateEhlers-Danlos syndromeVariant allele frequencyLoeys-DietzGermline mutationsCytokine productionCohort studyAneurysm developmentEhlers-DanlosAneurysmThromboexclusion Procedure for a Recurrent Descending Aortic Pseudoaneurysm in the Pre-Stent Era
Strachan S, Zafar M, Ziganshin B, Elefteriades J. Thromboexclusion Procedure for a Recurrent Descending Aortic Pseudoaneurysm in the Pre-Stent Era. Annals Of Thoracic Surgery Short Reports 2026, 4: 22-24. DOI: 10.1016/j.atssr.2025.07.015.Peer-Reviewed Original ResearchAltmetricEthnic variation in thoracic aortic dimensions in the general population: a comparison between Indian and Dutch populations
Bacour N, Idhrees M, Samraj J, Grewal S, Velayudhan B, Celik N, Zafar M, Elefteriades J, Grewal N. Ethnic variation in thoracic aortic dimensions in the general population: a comparison between Indian and Dutch populations. Open Heart 2026, 13: e003808. PMID: 41577370, PMCID: PMC12853485, DOI: 10.1136/openhrt-2025-003808.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsAortic dimensionsIndian patientsAortic diameterAortic archAortic rootAscending aortaDescending AortaAbdominal aortaDutch patientsRetrospective cohort studySurgical decision-makingIndividualised risk assessmentAortic complicationsConsecutive patientsSurgical thresholdMultivariate linear regression modelCurrent guidelinesSurgical guidelinesSurgical interventionWestern cohortsTreatment strategiesCohort studyAnatomical locationPatientsAorta
2025
Aortic wall lamellar structure in phylogeny and in humans: insights from bicuspid and tricuspid aortic valve morphology
Bacour N, Zafar M, Kargin N, Zinganshin B, Poelmann R, Klautz R, Elefteriades J, Grewal N. Aortic wall lamellar structure in phylogeny and in humans: insights from bicuspid and tricuspid aortic valve morphology. Cardiovascular Pathology 2025, 80: 107789. PMID: 41177471, DOI: 10.1016/j.carpath.2025.107789.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsTAV patientsBAV patientsElastic lamellaeAortic wallValve morphologyAortic valve morphologyAscending thoracic aortaAortic wall samplesFiber pathologyClinical outcomesThoracic aortaAbdominal aortaPathological featuresAortaAdult aortaPatientsTricuspidAge groupsAortopathyIntimal layerAdult humansBAVLiterature reviewAgeLamellar countNovel Aortic Root Measurement Technique Using the Laplace Diameter for Identifying Patients at Risk for Type A Dissection
Kalyanasundaram A, Harling L, Zafar M, Ellauzi H, Ziganshin B, Elefteriades J. Novel Aortic Root Measurement Technique Using the Laplace Diameter for Identifying Patients at Risk for Type A Dissection. Annals Of Thoracic Surgery Short Reports 2025, 3: 962-966. PMID: 41425403, PMCID: PMC12712140, DOI: 10.1016/j.atssr.2025.06.032.Peer-Reviewed Original ResearchThoracic Aortic Aneurysm and Giant Cell Arteritis: Clarifying the Link
Strachan S, Zafar M, Perincheri S, Ahmad A, Celik N, Changez M, Ziganshin B, Elefteriades J. Thoracic Aortic Aneurysm and Giant Cell Arteritis: Clarifying the Link. Aorta 2025, 13: 072-078. PMID: 41435904, DOI: 10.1055/a-2765-8610.Peer-Reviewed Original ResearchAltmetricConceptsGiant cell arteritisThoracic aortic aneurysmGiant cell arteritis diagnosisGiant cell arteritis patientsProgressive aortic enlargementAscending Aortic AneurysmAortic insufficiencyAortic aneurysmAortic enlargementIncidence of thoracic aortic aneurysmsCoronary diseaseGiant cell arteritis casesRisk of thoracic aortic aneurysmRisk factorsRelative riskDescending aortic aneurysmConcomitant polymyalgia rheumaticaSevere inflammatory responseDisruption of elastinAortic replacementAortic annulusPolymyalgia rheumaticaAneurysmal diseaseMale sexDiabetes mellitusEfficacy of beta-blocker agents on clinical outcomes in patients with thoracic aortic aneurysm: A systematic review and meta-analysis of randomized controlled trials
Tanriverdi L, Barrett A, Kalyanasundaram A, Zafar M, Ziganshin B, Elefteriades J. Efficacy of beta-blocker agents on clinical outcomes in patients with thoracic aortic aneurysm: A systematic review and meta-analysis of randomized controlled trials. Vascular Pharmacology 2025, 159: 107494. PMID: 40204023, DOI: 10.1016/j.vph.2025.107494.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsThoracic aortic aneurysmRandomized Controlled TrialsPooled risk ratioB-blockersAortic dissectionClinical outcomesAortic aneurysmRisk ratioRisk of aortic dissectionMeta-analysis of randomized controlled trialsControlled TrialsB-blocker treatmentCompared to placeboBeta-blocking agentsCochrane Risk of Bias 2 toolRisk of Bias 2 toolRobust randomized controlled trialsInverse variance-weighted random-effects modelRisk of bias assessmentRandom-effects modelEvidence of benefitSystematic literature searchAortic eventsEvidence-based recommendationsFollow-upEndovascular Repair vs Medical Therapy for Uncomplicated Acute Type B Dissection: Aortic Remodeling
Higaki A, Hameed I, Erez E, Hu K, Asmelash S, Chatterjee D, Shou B, Zafar M, Assi R, Vallabhajosyula P. Endovascular Repair vs Medical Therapy for Uncomplicated Acute Type B Dissection: Aortic Remodeling. Annals Of Thoracic Surgery Short Reports 2025, 3: 555-560. PMID: 41163911, PMCID: PMC12559255, DOI: 10.1016/j.atssr.2025.01.012.Peer-Reviewed Original ResearchCitationsConceptsUncomplicated acute type B aortic dissectionThoracic endovascular aortic repairOptimal medical therapyMedical therapyAortic remodelingAortic levelsClinical outcomesClinical outcomes of thoracic endovascular aortic repairLumen diameterPatients treated with thoracic endovascular aortic repairOutcomes of thoracic endovascular aortic repairUncomplicated acute type B dissectionAcute type B aortic dissectionOMT patientsAcute type B dissectionType B aortic dissectionFavorable aortic remodelingOptimal initial managementInitial treatment modalityMedian Follow-UpType B dissectionEndovascular aortic repairB aortic dissectionFalse lumen thrombosisLeft subclavian arteryGenetic Overlap of Thoracic Aortic Aneurysms and Intracranial Aneurysms
Changez M, Nasir A, Sonsino A, Jeoffrey S, Kalyanasundaram A, Zafar M, Ziganshin B, Elefteriades J. Genetic Overlap of Thoracic Aortic Aneurysms and Intracranial Aneurysms. Genes 2025, 16: 154. PMID: 40004483, PMCID: PMC11855647, DOI: 10.3390/genes16020154.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsGenome-wide association studiesThoracic aortic aneurysmGenetic overlapCell cycle pathwayIntracranial aneurysmsAortic aneurysmAssociation studiesEtiology of thoracic aortic aneurysmExtracellular matrix componentsGenetic interplayGenetic pathwaysCycle pathwayCausative genesExtracellular matrix remodelingThoracic aortic aneurysm patientsGenetic etiologyConnective tissue biologyRetrospective clinical studyMolecular mechanismsGenesIntracranial aneurysm patientsPhysiological pathwaysTissue biologyPathwayGenetic factorsMidterm outcomes of thoracic endovascular aortic repair versus optimal medical therapy for uncomplicated acute type B dissection
Hu K, Ma W, Pupovac S, Hameed I, Fereydooni S, Li E, Larson H, Zafar M, Tonnessen B, Cardella J, Aboian E, Guzman R, Chaar C, Strosberg D, Williams M, Nassiri N, Assi R, Vallabhajosyula P. Midterm outcomes of thoracic endovascular aortic repair versus optimal medical therapy for uncomplicated acute type B dissection. JTCVS Open 2025, 24: 67-76. PMID: 40309678, PMCID: PMC12039393, DOI: 10.1016/j.xjon.2024.12.013.Peer-Reviewed Original ResearchCitationsAltmetricConceptsThoracic endovascular aortic repairThoracic endovascular aortic repair groupOptimal medical therapyOptimal medical therapy groupMidterm outcomes of thoracic endovascular aortic repairOutcomes of thoracic endovascular aortic repairUncomplicated acute type B aortic dissectionEndovascular aortic repairAcute kidney injuryAortic repairMidterm outcomesMedical therapyUncomplicated acute type B dissectionAcute type B aortic dissectionAcute type B dissectionAssociated with improved survivalType B aortic dissectionThirty-day ratesType B dissectionB aortic dissectionPost-operative dataMidterm follow-upIn-hospital/30-day mortalityKaplan-Meier survivalB dissection
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