Meredith Gwin
she/her/hers
Postdoctoral FellowDownloadHi-Res Photo
About
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Titles
Postdoctoral Fellow
Departments & Organizations
Education & Training
- PhD
- University of South Alabama Whiddon College of Medicine, Physiology and Cell Biology (2023)
- BS
- University of Mobile, Biology (2016)
- AA
- Coastal Alabama Community College , Liberal Arts (2014)
- AS
- Coastal Alabama Community College , General Studies (2014)
Research
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Overview
Public Health Interests
Aging; Chronic Diseases; Emerging Infectious Diseases; Infectious Diseases; Respiratory Disease/Infections; COVID-19
ORCID
0000-0002-3084-8032
Research at a Glance
Publications Timeline
A big-picture view of Meredith Gwin's research output by year.
9Publications
119Citations
Publications
2026
Tau is necessary for Pseudomonas aeruginosa-induced blood-brain barrier dysfunction
Chaney S, Bauman A, Butlig E, Al-Masri S, Montoya Sanchez J, McAdams L, Doan P, Gwin M, Stevens T, Ciernia A, Lin M, Nelson A. Tau is necessary for Pseudomonas aeruginosa-induced blood-brain barrier dysfunction. Communications Biology 2026, 9: 427. PMID: 41688665, PMCID: PMC13013825, DOI: 10.1038/s42003-026-09703-x.Peer-Reviewed Original ResearchCitationsAltmetric
2025
Carbonic anhydrase IX promotes acute lung injury and mortality in females during metabolic acidosis and pneumonia
Stevens R, Holston J, Maatouk K, Zhou C, Stone M, Pastukh V, Francis M, Kumar S, Gwin M, Sayner S, Stevens T, Lee J. Carbonic anhydrase IX promotes acute lung injury and mortality in females during metabolic acidosis and pneumonia. American Journal Of Physiology - Lung Cellular And Molecular Physiology 2025, 329: l266-l281. PMID: 40623021, PMCID: PMC12305884, DOI: 10.1152/ajplung.00331.2024.Peer-Reviewed Original ResearchCitationsAltmetric
2023
PFKFB3 Inhibits Fructose Metabolism in Pulmonary Microvascular Endothelial Cells.
Lee J, Stevens R, Pastukh V, Pastukh V, Kozhukhar N, Alexeyev M, Reisz J, Nerguizian D, D'Alessandro A, Koloteva A, Gwin M, Roberts J, Borchert G, Wagener B, Pittet J, Graham B, Stenmark K, Stevens T. PFKFB3 Inhibits Fructose Metabolism in Pulmonary Microvascular Endothelial Cells. American Journal Of Respiratory Cell And Molecular Biology 2023, 69: 340-354. PMID: 37201952, PMCID: PMC10503305, DOI: 10.1165/rcmb.2022-0443oc.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptspulmonary microvascular endothelial cellsknockout cellsmicrovascular endothelial cellsfructose metabolismwild-type cellsendothelial cellsstable isotope tracingoxidative phosphorylationglycolytic fluxglycolytic enzymescell metabolismmicroarray analysisendothelial cell metabolismmolecular switchSeahorse assayPFKFB3glycolysisfructoserespiratory failureBAL fluidknockout miceisotope tracingGamma secretase activating protein promotes end-organ dysfunction after bacterial pneumonia
Gwin M, Alexeyev M, Geurts A, Lee J, Zhou C, Yang X, Cohen M, Downey J, Barrington R, Spadafora D, Audia J, Frank D, Voth S, Pastukh V, Bell J, Ayers L, Tambe D, Nelson A, Balczon R, Lin M, Stevens T. Gamma secretase activating protein promotes end-organ dysfunction after bacterial pneumonia. American Journal Of Physiology - Lung Cellular And Molecular Physiology 2023, 325: l174-l189. PMID: 37366533, PMCID: PMC10396227, DOI: 10.1152/ajplung.00018.2023.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsgamma-secretase activating proteinend-organ dysfunctionlong-term potentiationknockout ratswild-type ratsamyloidogenic pathwayactivator proteinbacterial pneumonialung injuryneurotransmitter release probabilitymyocardial infarctionrelease probabilityalveolar-capillary barrier integrityhyperdynamic circulatory statewild-typeacute lung injuryblood cell countischemia-reperfusion injuryrisk of myocardial infarctionarterial blood gasescardiac indexpostsynaptic responsesbeta-amyloidInfection promotes Ser‐214 phosphorylation important for generation of cytotoxic tau variants
Balczon R, Choi C, deWeever A, Zhou C, Gwin M, Kolb C, Francis C, Lin M, Stevens T. Infection promotes Ser‐214 phosphorylation important for generation of cytotoxic tau variants. The FASEB Journal 2023, 37: e23042-e23042. PMID: 37358817, PMCID: PMC12306725, DOI: 10.1096/fj.202300620rr.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsphosphorylation of tauoligomeric tautau variantslong-term potentiationphosphorylation statusphosphorylationhippocampal long-term potentiationend-organ dysfunctionhospital-acquired pneumonialong-term morbiditypulmonary endothelial cellstaualveolar-capillary barriercytotoxic propertiesvariantsinfectious pneumoniahospital dischargepneumoniaendothelial cellsend organscognitive deficits
2021
Cytotoxic tau released from lung microvascular endothelial cells upon infection with Pseudomonas aeruginosa promotes neuronal tauopathy
Choi C, Gwin M, Voth S, Kolb C, Zhou C, Nelson A, deWeever A, Koloteva A, Annamdevula N, Murphy J, Wagener B, Pittet J, Lim S, Balczon R, Stevens T, Lin M. Cytotoxic tau released from lung microvascular endothelial cells upon infection with Pseudomonas aeruginosa promotes neuronal tauopathy. Journal Of Biological Chemistry 2021, 298: 101482. PMID: 34896150, PMCID: PMC8718960, DOI: 10.1016/j.jbc.2021.101482.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptstau aggregationtau isoformsrepeat domainPseudomonas aeruginosareporter cellsneuronal tauknockout cellsendothelial cellsAlzheimer's disease patientsbacterial lung infectionstaulung microvascular endothelial cellstauopathieslung endothelial cellslong-term potentiationisoformsmicrovascular endothelial cellscellslung infectionknockout micenosocomial pneumoniaCarbonic Anhydrase IX and Hypoxia Promote Rat Pulmonary Endothelial Cell Survival during Infection.
Lee J, Stevens R, Kash M, Alexeyev M, Balczon R, Zhou C, Renema P, Koloteva A, Kozhukhar N, Pastukh V, Gwin M, Voth S, deWeever A, Wagener B, Pittet J, Eslaamizaad Y, Siddiqui W, Nawaz T, Clarke C, Fouty B, Audia J, Alvarez D, Stevens T. Carbonic Anhydrase IX and Hypoxia Promote Rat Pulmonary Endothelial Cell Survival during Infection. American Journal Of Respiratory Cell And Molecular Biology 2021, 65: 630-645. PMID: 34251286, PMCID: PMC8641799, DOI: 10.1165/rcmb.2020-0537oc.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptspulmonary microvascular endothelial cellsCA IXbronchoalveolar fluidplasma concentrationslow tidal volume ventilationCA IX expressiontidal volume ventilationprotective effectMechanically Ventilated Patientscritically ill patientscarbonic anhydrase IXmicrovascular endothelial cellsendothelial cell survivaleffects of hypoxiaIX expressionvolume ventilationill patientsendothelial cellslungcell recovery
2020
Pneumonia-induced endothelial amyloids reduce dendritic spine density in brain neurons
Scott A, Jager A, Gwin M, Voth S, Balczon R, Stevens T, Lin M. Pneumonia-induced endothelial amyloids reduce dendritic spine density in brain neurons. Scientific Reports 2020, 10: 9327. PMID: 32518286, PMCID: PMC7283224, DOI: 10.1038/s41598-020-66321-1.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsendothelial cell releasedendritic spine densityblood-brain barrierspine densityintraperitoneal injectioncerebrospinal fluidstructural remodelingPseudomonas aeruginosa pneumoniasynaptic long-term potentiationcritically ill patientslong-term potentiationdensity in vivobronchoalveolar lavagelung originlateral ventricleelectrophysiological studiesbrain slicesill patientshippocampal signalbrain neuronshippocampal dendritesVirulent Pseudomonas aeruginosa infection converts antimicrobial amyloids into cytotoxic prions
Voth S, Gwin M, Francis C, Balczon R, Frank D, Pittet J, Wagener B, Moser S, Alexeyev M, Housley N, Audia J, Piechocki S, Madera K, Simmons A, Crawford M, Stevens T. Virulent Pseudomonas aeruginosa infection converts antimicrobial amyloids into cytotoxic prions. The FASEB Journal 2020, 34: 9156-9179. PMID: 32413239, PMCID: PMC7383673, DOI: 10.1096/fj.202000051rrr.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsvirulence arsenaltype III secretion systemIII secretion systemmolecular mechanismshost-pathogen interactionsresponse to bacterial infectionfunctional T3SSsecretion systemP aeruginosaclinical strainsbeta-amyloidamyloid productionT3SShost defenseamyloidlung endotheliumPseudomonas aeruginosa infectioninnate immunityexoenzyme
Academic Achievements & Community Involvement
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Activities
activity American Thoracic Society
08/01/2017 - PresentProfessional OrganizationsMemberactivity American Heart Association
2019 - 2020Professional OrganizationsPrincipal InvestigatorDetailsPI on an predoctoral fellowship awarded for 2 years.
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Mailing Address
Pulmonary, Critical Care & Sleep Medicine
1 Gilbert St, TAC
New Haven, CT 06510
United States