Marta Piecychna
Research Assistant Internal Medicine RheumatologyCards
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Research Assistant Internal Medicine Rheumatology
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Research at a Glance
Yale Co-Authors
Frequent collaborators of Marta Piecychna's published research.
Richard Bucala, MD, PhD
Insoo Kang, MD
Jennefer Par-Young
Buqu Hu
Elias Lolis, PhD
Laura Abriola
Publications
2025
Enhanced antibody class switching and T cell responses to a self-amplifying RNA vs mRNA vaccine against SARS-CoV-2 spike protein 4547
Doherty E, Par-Young J, Osmani L, Filler R, Piecychna M, Abraham S, Jain N, Thambatti S, Nazaripour S, Thomas A, Leng L, Unutmaz D, Wilen C, Geall A, Kang I, Bucala R. Enhanced antibody class switching and T cell responses to a self-amplifying RNA vs mRNA vaccine against SARS-CoV-2 spike protein 4547. The Journal Of Immunology 2025, 214 DOI: 10.1093/jimmun/vkaf283.2218.Peer-Reviewed Original ResearchIncreased antibody diversification in mice vaccinated with a self-amplifying RNA versus mRNA directed against SARS-CoV-2 spike protein 9225
Par-Young J, Osmani L, Doherty E, Piecychna M, Abraham S, Jain N, Thambatti S, Nazaripour S, Thomas A, Leng L, Geall A, Kang I, Bucala R. Increased antibody diversification in mice vaccinated with a self-amplifying RNA versus mRNA directed against SARS-CoV-2 spike protein 9225. The Journal Of Immunology 2025, 214 DOI: 10.1093/jimmun/vkaf283.2654.Peer-Reviewed Original Research
2024
CD74 promotes the formation of an immunosuppressive tumor microenvironment in triple-negative breast cancer in mice by inducing the expansion of tolerogenic dendritic cells and regulatory B cells
Pellegrino B, David K, Rabani S, Lampert B, Tran T, Doherty E, Piecychna M, Meza-Romero R, Leng L, Hershkovitz D, Vandenbark A, Bucala R, Becker-Herman S, Shachar I. CD74 promotes the formation of an immunosuppressive tumor microenvironment in triple-negative breast cancer in mice by inducing the expansion of tolerogenic dendritic cells and regulatory B cells. PLOS Biology 2024, 22: e3002905. PMID: 39576827, PMCID: PMC11623796, DOI: 10.1371/journal.pbio.3002905.Peer-Reviewed Original ResearchCitationsAltmetricConceptsTriple-negative breast cancerMacrophage migration inhibitory factorImmunosuppressive tumor microenvironmentTolerogenic dendritic cellsRegulatory B cellsChronic lymphocytic leukemiaTumor microenvironmentDendritic cellsImmune cellsB cellsBreast cancerInfiltration of immune cellsAggressive breast cancer subtypeMassive infiltration of immune cellsLevels of CD74Cytokine macrophage migration inhibitory factorBreast cancer subtypesMigration inhibitory factorBinding to CD74Naive BTol-DCsLymphocytic leukemiaTumor environmentMassive infiltrationCancer subtypesMIF-CD74 Pathway and Its Effect on Effector T Cell Exhaustion in Alloimmunity
Younis N, Al Rahy N, Solhjou Z, Kurdi A, Zhang H, Al Chaar S, Djebli H, Badaoui A, Choi J, Piecychna M, Doherty E, Bucala R, Azzi J. MIF-CD74 Pathway and Its Effect on Effector T Cell Exhaustion in Alloimmunity. Journal Of The American Society Of Nephrology 2024, 35: 10.1681/asn.202461m1r2m1. DOI: 10.1681/asn.202461m1r2m1.Peer-Reviewed Original ResearchA small-molecule allele-selective transcriptional inhibitor of the MIF immune susceptibility locus
Li J, Leng L, Pantouris G, Manjula R, Piecychna M, Abriola L, Hu B, Lolis E, Armstrong M, Donnelly S, Bucala R. A small-molecule allele-selective transcriptional inhibitor of the MIF immune susceptibility locus. Journal Of Biological Chemistry 2024, 300: 107443. PMID: 38838773, PMCID: PMC11259703, DOI: 10.1016/j.jbc.2024.107443.Peer-Reviewed Original ResearchCitationsAltmetricConceptsPromoter microsatellitesGene expressionMicrosatellite repeat numberMacrophage migration inhibitory factorLength-dependent mannerRNA expression analysisSusceptibility lociFunctional variantsSmall molecule inhibitorsExpression analysisPharmacogenomic developmentRepeat numberMicrosatelliteFunctional interactionsTranscription inhibitorInflammatory gene expressionMIF mRNA expressionCytokine macrophage migration inhibitory factorTranscriptionGenesProtein expressionMigration inhibitory factorExpressionInhibitory factorExpressing macrophages
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