Adjunct faculty typically have an academic or research appointment at another institution and contribute or collaborate with one or more School of Medicine faculty members or programs.
Adjunct rank detailsMaria Lalioti, PhD
About
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Titles
Assistant Professor Adjunct of Obstetrics, Gynecology & Reproductive Sciences, Obstetrics, Gynecology & Reproductive Sciences
Biography
Dr. Maria D Lalioti is an Adjunct Assistant Professor of Obstetrics and Gynecology at the Yale School of Medicine. She is a human molecular geneticist with a strong interest in personalized medicine and ethical use of genomic information. She obtained her undergraduate degree in Biology from the University of Athens, Greece and her PhD in Human Molecular Genetics from the University of Geneva, Switzerland. She did her postdoctoral training in Biochemistry at the University of Birmingham, UK and in Genetics / Nephrology at Yale School of Medicine. During her postdoctoral training, she was awarded the prestigious EMBO (European Molecular Biology Organization) and HFSP (Human Frontier Science Program) fellowships. Upon completion of her postdoc, she was recruited to join the Yale Division of Reproductive Endocrinology and Infertility as an Assistant Professor, where she set up and directed the Preimplantation Genetics program and a laboratory doing translational research.
At Yale, her research focused on the genetics of reproductive disorders and the functional consequences of gene variants on ovarian function including response to ovarian stimulation. She has published extensively in high impact journals. She is the recipient of multiple awards for research excellence, including awards for basic and preclinical research from the American Society of Human Genetics (ASHG), the Nature Genetics Journal, the European Society of Human Genetics (ESHG) and the European Society of Human Reproduction and Embryology (ESHRE) and the Pfizer foundation.
After Yale, she has held positions of increasing responsibility in Biotech companies (Biogen, Goldfinch Bio, and Beam Tx) specializing in drug target discovery and portfolio strategy in therapeutic areas of expertise (renal, reproductive, metabolic, neurodenerative, and orphan diseases), and supported programs using diverse modalities including novel ones such as gene therapy and gene editing. She is an advisor of several biotech companies and she is interested in leveraging genomic discoveries for drug development.
Dr Lalioti is very involved with American Society of Human Genetics (ASHG), where she is a member of the Career Development Committee and co-organizer of the Society’s mentoring programs. She is an Associate editor for Molecular Human Reproduction (MHR) and serves as an abstract reviewer for ESHRE and ASHG congresses. She also serves at the Board of Directors of WEST (Women in the Enterprise of Science and Technology). She is a mentor with WEST and other professional organizations where she helps women scientists reach their full potential. She co-teaches the Yale Biology of Reproduction undergraduate course and mentors undergraduate students.
Departments & Organizations
Education & Training
- Postdoctoral fellow
- Yale School Medicine (2005)
- Postdoctoral fellow
- Birmingham University (2001)
- PhD
- University of Geneva (1998)
- MSc
- University of Geneva, Medical Biology (1994)
- BSc (Hon)
- National and Kapodistrian University of Athens, Biology (1991)
Research
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Overview
- Identification and Functional Characterization of Follicle Stimulating Hormone Receptor (FSHR) Variants
Research at a Glance
Yale Co-Authors
Emre Seli, MD
Frederick Wilson, MD, PhD
Joan Steitz, PhD
Publications
2005
Interchromosomal associations between alternatively expressed loci
Spilianakis CG, Lalioti MD, Town T, Lee GR, Flavell RA. Interchromosomal associations between alternatively expressed loci. Nature 2005, 435: 637-645. PMID: 15880101, DOI: 10.1038/nature03574.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsMeSH KeywordsAllelesAnimalsCell NucleusCells, CulturedChromatinChromosome PositioningChromosomes, MammalianCytokinesDeoxyribonuclease IEnhancer Elements, GeneticGene Expression RegulationIn Situ Hybridization, FluorescenceInterferon-gammaInterleukinsLocus Control RegionMiceMice, Inbred C57BLPolymerase Chain ReactionPromoter Regions, GeneticRNA, MessengerTh1 CellsTh2 CellsTranscriptional ActivationConceptsLocus control regionTh2 locus control regionInterchromosomal interactionsDNase I hypersensitive sitesTh2 cytokine locusT cell fateEukaryotic genesIntrachromosomal interactionsChromatin conformationInterchromosomal associationsCytokine genesDifferent chromosomesGene activationSeparate chromosomesControl regionRegulatory regionsHypersensitive sitesCytokine locusTh2 cytokine genesChromosome 10Gene expressionPromoter regionChromosome 11GenesFunctional consequencesAn embryonic poly(A)-binding protein (ePAB) is expressed in mouse oocytes and early preimplantation embryos
Seli E, Lalioti MD, Flaherty SM, Sakkas D, Terzi N, Steitz JA. An embryonic poly(A)-binding protein (ePAB) is expressed in mouse oocytes and early preimplantation embryos. Proceedings Of The National Academy Of Sciences Of The United States Of America 2005, 102: 367-372. PMID: 15630085, PMCID: PMC544294, DOI: 10.1073/pnas.0408378102.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsZygotic gene activationGene activationEarly embryosSomatic cellsTranslational activationGene expressionEmbryo developmentEarly preimplantation embryo developmentEarly Xenopus developmentEarly preimplantation embryosEight-cell stageEarly embryo developmentPreimplantation embryo developmentTwo-cell embryosCytoplasmic PABPMouse orthologXenopus developmentMammalian oocytesProphase ISomatic tissuesChromosome 2Preimplantation embryosEPABMouse oocytesOne-cell
2004
WNK kinases: molecular regulators of integrated epithelial ion transport
Kahle KT, Wilson FH, Lalioti M, Toka H, Qin H, Lifton RP. WNK kinases: molecular regulators of integrated epithelial ion transport. Current Opinion In Nephrology & Hypertension 2004, 13: 557-562. PMID: 15300163, DOI: 10.1097/00041552-200409000-00012.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsPseudohypoaldosteronism type IIWNK kinasesPotassium ion channelsChloride ion fluxIon channelsSerine-threonine kinaseCoordinated regulationDiverse epitheliaMolecular regulatorsMolecular switchKinasePotassium ion secretionDynamic regulatorGeneral roleDisease physiologyIon fluxIntegrated regulationElectrolyte homeostasisEpithelial ion transportEpithelial transportersEssential roleWNK4HomeostasisFlux pathwaysMutationsSkeletal development is regulated by fibroblast growth factor receptor 1 signalling dynamics.
Hajihosseini MK, Lalioti MD, Arthaud S, Burgar HR, Brown JM, Twigg SR, Wilkie AO, Heath JK. Skeletal development is regulated by fibroblast growth factor receptor 1 signalling dynamics. Development (Cambridge, England) 2004, 131: 325-35. PMID: 14668415, DOI: 10.1242/dev.00940.Peer-Reviewed Original Research
Academic Achievements & Community Involvement
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Activities
activity American society of Human Genetics
2023 - PresentProfessional OrganizationsCommittee MemberDetailsMember of the Career Development Committeeactivity Women in the Enterprise of Science and Technology (WEST)
2026 - PresentProfessional OrganizationsBoard of Directorsactivity Advisory board
10/01/2023 - 12/31/2025Advisory BoardsAdvisorDetailsWomen in the Enterprise of Science and Technology (WEST)
Teaching & Mentoring
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Teaching
Didactic MCDB 250 Biology of Reproduction
LecturerLecture SettingDetails1/1/2008 - PresentForUndergraduate5 Average Instructional Hours Per YearIntroduction to reproductive biology, with emphasis on human reproduction. Development and hormonal regulation of reproductive systems; sexuality, fertilization, and pregnancy; modern diagnosis and treatment of reproductive and developmental disorders; social and ethical issues.
Willing and Available to Mentor
- Students
- Residents
- Postdoctoral Researchers
- Clinical Fellows
- Clinicians
- Faculty
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