Lin Wang, MS
Research Associate Laboratory MedicineDownloadHi-Res Photo
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Research Associate in Laboratory Medicine
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Research Associate Laboratory Medicine
Research Associate in Laboratory Medicine
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Education & Training
- MS
- University of New Haven, Molecular/Cell Biology (2003)
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Research at a Glance
Yale Co-Authors
Frequent collaborators of Lin Wang's published research.
Publications Timeline
A big-picture view of Lin Wang's research output by year.
Diane Krause, MD, PhD
Emanuela Bruscia, PhD
Stephanie Halene, MD, Dr Med
Vanessa Scanlon, PhD
Amos Espinosa
Clemente Britto-Leon, MD
16Publications
379Citations
Publications
2025
RBM15-MKL1 fusion protein promotes leukemia via m6A methylation and Wnt pathway activation
Mayday M, Biancon G, Wei M, Ramirez C, Moratti I, Pintado-Urbanc A, Espinosa J, Chen M, Wang L, Simon M, Ofir-Rosenfeld Y, Rausch O, Tebaldi T, Halene S, Krause D. RBM15-MKL1 fusion protein promotes leukemia via m6A methylation and Wnt pathway activation. Blood 2025, 146: 1096-1109. PMID: 40435410, DOI: 10.1182/blood.2024027712.Peer-Reviewed Original ResearchCitationsAltmetricConceptsRNA fateM6A modificationFusion proteinWnt pathway activationFrizzled genesFunctions of RBM15Dysregulation of m6A modificationRBM15-MKL1Pathway activationMulti-omics approachInduced apoptosis in vitroWnt Signaling PathwayApoptosis in vitroM6A depositionRNA bindingSpecific RNAGrowth in vitroM6A methylationMRNA targetsSignaling pathwayWnt pathwayWnt signalingM6A modifiersM6A-dependent mechanismRNA
2024
CDK9 phosphorylates RUNX1 to promote megakaryocytic fate in megakaryocytic-erythroid progenitors
Kwon N, Lu Y, Thompson E, Mancuso R, Wang L, Zhang P, Krause D. CDK9 phosphorylates RUNX1 to promote megakaryocytic fate in megakaryocytic-erythroid progenitors. Blood 2024, 144: 1800-1812. PMID: 39102635, PMCID: PMC11530366, DOI: 10.1182/blood.2024023963.Peer-Reviewed Original ResearchCitationsAltmetricConceptsMegakaryocytic-erythroid progenitorsWild-typeFate specificationRUNX1 levelsCell lines expressing wild-typeHuman erythroleukemiaInhibition of CDK9Cell-type specific transcription factorsMK-specificRUNX1 variantsDifferentially regulates expressionErythroid commitmentHematopoietic homeostasisHuman erythroleukemia cellsMK progenitorsOverexpression of RUNX1Megakaryocyte fateDecreased expressionRUNX1Mimetic mutationNon-phosphorylatableTranscription machineryFunctional efficacySerine/threonine phosphorylationSerine/threonine kinase3046 – FUNCTIONAL CHARACTERIZATION OF RBM15-MKL1 FUSION PROTEIN IN AMKL TUMORIGENESIS
Chen M, Mayday M, Espinosa A, Zhang M, Zhang P, Wang L, Rahman N, Krause D. 3046 – FUNCTIONAL CHARACTERIZATION OF RBM15-MKL1 FUSION PROTEIN IN AMKL TUMORIGENESIS. Experimental Hematology 2024, 137: 104368. DOI: 10.1016/j.exphem.2024.104368.Peer-Reviewed Original ResearchConceptsChromatin associationRBM15-MKL1TPA-induced megakaryocytic differentiationHuman erythroleukemiaAcute megakaryoblastic leukemiaAssociated with chromatinTranscriptional regulatory functionRNA-binding proteinsTranscriptional co-activatorM6A RNA modificationShRNA-mediated knock-downHuman erythroleukemia cellsChromatin regionsRNA modificationsTranscriptional regulationMolecular functionsAberrant transcriptsFusion proteinGO analysisMKL1Knock-downBinding proteinRegulatory functionsFusion geneDifferentiation block3070 – IMPLICATING THE SPOC DOMAIN OF RBM15 IN RBM15-MKL1 FUSION PROTEIN-INDUCED ACUTE MEGAKARYOBLASTIC LEUKEMIA
Espinosa A, Mayday M, Chen M, Zhang P, Wang L, Mohammed H. 3070 – IMPLICATING THE SPOC DOMAIN OF RBM15 IN RBM15-MKL1 FUSION PROTEIN-INDUCED ACUTE MEGAKARYOBLASTIC LEUKEMIA. Experimental Hematology 2024, 137: 104392. DOI: 10.1016/j.exphem.2024.104392.Peer-Reviewed Original ResearchConceptsSPOC domainRBM15-MKL1Fusion proteinRNA-binding motifRNA-binding motif proteinAcute megakaryoblastic leukemiaHuman erythroleukemiaM6A writer complexMegakaryoblastic leukemia 1Alanine scanning mutagenesisM6A RNA modificationChimeric fusion proteinMK maturationHuman erythroleukemia cellsMotif proteinRNA modificationsPediatric acute megakaryoblastic leukemiaFunctional motifsScanning mutagenesisAlanine mutantsChromosomal translocationsWriter complexN6-methyladenosineRBM15Amino acids
2023
3092 – CRISPR OPTIMIZATION TO SCREEN FOR GENES THAT REGULATE FATE SPECIFICATION OF PRIMARY HUMAN HEMATOPOIETIC PROGENITORS
Mancuso R, Thompson E, Wang L, Krause D. 3092 – CRISPR OPTIMIZATION TO SCREEN FOR GENES THAT REGULATE FATE SPECIFICATION OF PRIMARY HUMAN HEMATOPOIETIC PROGENITORS. Experimental Hematology 2023, 124: s96. DOI: 10.1016/j.exphem.2023.06.199.Peer-Reviewed Original ResearchConceptsFate specificationMCherry fluorescent reporterFluorescent reportersNumber of genesLarge-scale screenDNA-PK inhibitorPrimary human hematopoietic progenitorsHuman hematopoietic progenitorsCD45-negative cellsPanel of genesCRISPR screensErythroid maturationSingle guideMolecular mechanismsGRNAGRNA sequencesNegative cellsGenesHematopoietic progenitorsLentiviral transductionTotal RNAReporterProgenitorsTransfectionCell number3108 – PHOSPHORYLATION OF RUNX1 PROMOTES MEGAKARYOCYTIC FATE IN MEGAKARYOCYTE-ERYTHROID PROGENITOR FATE SPECIFICATION
Kwon N, Lu Y, Thompson E, Wang L, Zhang P, Krause D. 3108 – PHOSPHORYLATION OF RUNX1 PROMOTES MEGAKARYOCYTIC FATE IN MEGAKARYOCYTE-ERYTHROID PROGENITOR FATE SPECIFICATION. Experimental Hematology 2023, 124: s104. DOI: 10.1016/j.exphem.2023.06.215.Peer-Reviewed Original ResearchConceptsMegakaryocyte-erythroid progenitorsFate specificationHEL cellsGene expressionSingle-cell RNA-seq dataPost-translational modificationsDifferential gene expressionRNA-seq dataChromatin localizationRNA-seqPhosphorylation statusRUNX1 overexpressionE progenitorsTranscriptional activityKey regulatorRUNX1 mRNAMK progenitorsT residuesGenesErythroid progenitorsRUNX1MKPProgenitorsProtein levelsSpecification mechanism
2022
Structure-function analysis of the role of megakaryoblastic leukemia 1 in megakaryocyte polyploidization.
Reed FE, Eskow NM, Min E, Carlino M, Mancuso R, Kwon N, Smith EC, Larsuel ST, Wang L, Scanlon V, Krause DS. Structure-function analysis of the role of megakaryoblastic leukemia 1 in megakaryocyte polyploidization. Haematologica 2022 PMID: 36005559.Peer-Reviewed Original ResearchStructure-function analysis of the role of megakaryoblastic leukemia 1 in megakaryocyte polyploidization
Reed F, Eskow N, Min E, Carlino M, Mancuso R, Kwon N, Smith E, Larsuel S, Wang L, Scanlon V, Krause D. Structure-function analysis of the role of megakaryoblastic leukemia 1 in megakaryocyte polyploidization. Haematologica 2022, 107: 2972-2976. PMID: 36453520, PMCID: PMC9713552, DOI: 10.3324/haematol.2021.280499.Peer-Reviewed Original ResearchCitationsAltmetric
2018
The Molecular Signature of Megakaryocyte-Erythroid Progenitors Reveals a Role for the Cell Cycle in Fate Specification
Lu YC, Sanada C, Xavier-Ferrucio J, Wang L, Zhang PX, Grimes HL, Venkatasubramanian M, Chetal K, Aronow B, Salomonis N, Krause DS. The Molecular Signature of Megakaryocyte-Erythroid Progenitors Reveals a Role for the Cell Cycle in Fate Specification. Cell Reports 2018, 25: 3229. PMID: 30540953, PMCID: PMC6357951, DOI: 10.1016/j.celrep.2018.11.075.Peer-Reviewed Original ResearchCitationsAltmetricSurfactant protein C dampens inflammation by decreasing JAK/STAT activation during lung repair
Jin H, Ciechanowicz AK, Kaplan AR, Wang L, Zhang P, Lu YC, Tobin RE, Tobin BA, Cohn L, Zeiss CJ, Lee PJ, Bruscia EM, Krause DS. Surfactant protein C dampens inflammation by decreasing JAK/STAT activation during lung repair. American Journal Of Physiology - Lung Cellular And Molecular Physiology 2018, 314: l882-l892. PMID: 29345196, PMCID: PMC6008135, DOI: 10.1152/ajplung.00418.2017.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsAcute respiratory distress syndromeKO miceSurfactant protein CClinical acute respiratory distress syndromeProtein CAlveolar type 2 cellsAnti-inflammatory mediatorsRespiratory distress syndromeBronchoalveolar lavage fluidAnti-inflammatory moleculesPhosphorylated signal transductionType 2 cellsSPC expressionInducible suicide geneJanus kinaseLevels of suppressorDistress syndromeBAL fluidGranulocyte infiltrationJAK1/2 inhibitorLavage fluidProinflammatory phenotypeInflammatory cytokinesSevere inflammationInjury model
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