Leah Harmon
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McDougal Teaching Fellow , Poorvu Center for Teaching and LearningAbout
Research
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2023
α-Synuclein Pathology and Reduced Neurogenesis in the Olfactory System Affect Olfaction in a Mouse Model of Parkinson's Disease
Martin-Lopez E, Vidyadhara D, Liberia T, Meller S, Harmon L, Hsu R, Spence N, Brennan B, Han K, Yücel B, Chandra S, Greer C. α-Synuclein Pathology and Reduced Neurogenesis in the Olfactory System Affect Olfaction in a Mouse Model of Parkinson's Disease. Journal Of Neuroscience 2023, 43: 1051-1071. PMID: 36596700, PMCID: PMC9908323, DOI: 10.1523/jneurosci.1526-22.2022.Peer-Reviewed Original ResearchConceptsα-syn tg miceα-Syn pathologyolfactory bulb neurogenesisprojection neuronsParkinson's diseaseolfactory dysfunctionmutant α-synucleinolfactory deficitsolfactory pathwaysyn pathologybehavioral deficitsmouse modelα-synucleinOB granule cellsα-synuclein pathologyolfactory systemmonths of agereduced neurogenesisfunctional deficitsperiglomerular cellsmotor progressionpathologic changesmultiple symptomssynaptic terminalsgranule cells
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