Laura Aponte Becerra
Clinical FellowAbout
Research
Publications
2025
Trends of preemptive kidney transplantation in lupus compared to other primary diseases leading to end stage kidney disease in the United States of America
Contreras G, Pagan J, Elfassy T, Bandes M, Bustamante N, Ortigosa-Goggins M, Becerra L, Mendoza J, Drexler Y, Alonso S, Roth D. Trends of preemptive kidney transplantation in lupus compared to other primary diseases leading to end stage kidney disease in the United States of America. Lupus 2025, 34: 775-786. PMID: 40391526, DOI: 10.1177/09612033251344189.Peer-Reviewed Original ResearchConceptsKidney allograft failurePreemptive kidney transplantationEnd-stage kidney diseasePolycystic kidney diseaseRisk of kidney allograft failureAll-Cause MortalityUnited States Renal Data SystemNon-lupusGlomerular diseaseKidney diseaseDM recipientsLupus patientsKidney transplantationRisk of all-cause mortalityNon-lupus patientsEnd stage kidney diseaseIncident ESKD patientsStage kidney diseaseCochran-Armitage testAllograft failurePrimary diseasePoor outcomeHypertensionLupusPatients
2024
Preemptive Kidney Transplantation Trends in Lupus
Contreras G, Pagan J, Elfassy T, Bandes M, Bustamante N, Goggins M, Becerra L, Mendoza J, Drexler Y, Alonso S, Roth D. Preemptive Kidney Transplantation Trends in Lupus. Journal Of The American Society Of Nephrology 2024, 35: 10.1681/asn.2024p18r0q9c. DOI: 10.1681/asn.2024p18r0q9c.Peer-Reviewed Original ResearchInfluenza B Triggering Atypical Hemolytic Uremic Syndrome (aHUS) in a Patient with Cobalamin C (CblC) Disease Carrier State and a Complement Factor H (CFH) Mutation
Becerra L, Moeckel G, Gunasekaran D. Influenza B Triggering Atypical Hemolytic Uremic Syndrome (aHUS) in a Patient with Cobalamin C (CblC) Disease Carrier State and a Complement Factor H (CFH) Mutation. Journal Of The American Society Of Nephrology 2024, 35: 10.1681/asn.2024vajywpws. DOI: 10.1681/asn.2024vajywpws.Peer-Reviewed Original ResearchMinimal Change Disease (MCD) and Human Chorionic Gonadotropin (hCG)-Mediated Thyrotoxicosis during Pregnancy
Becerra L, Moeckel G, Gondal M. Minimal Change Disease (MCD) and Human Chorionic Gonadotropin (hCG)-Mediated Thyrotoxicosis during Pregnancy. Journal Of The American Society Of Nephrology 2024, 35: 10.1681/asn.2024f2jtc080. DOI: 10.1681/asn.2024f2jtc080.Peer-Reviewed Original ResearchWCN24-330 TRENDS OF PREEMPTIVE KIDNEY TRANSPLANTATION IN PATIENTS APPROACHING END-STAGE RENAL DISEASE STRATIFIED BY PRIMARY DISEASE IN THE UNITED STATES FROM 1985 AND 2019
Martin G, Pagan J, Bustamante N, Ortigosa-Goggins M, Bandes M, Elfassy T, Becerra L, Mendoza J, Morales E, Drexler Y, Kupin W, Roth D. WCN24-330 TRENDS OF PREEMPTIVE KIDNEY TRANSPLANTATION IN PATIENTS APPROACHING END-STAGE RENAL DISEASE STRATIFIED BY PRIMARY DISEASE IN THE UNITED STATES FROM 1985 AND 2019. Kidney International Reports 2024, 9: s442-s443. DOI: 10.1016/j.ekir.2024.02.929.Peer-Reviewed Original ResearchEffects of Empagliflozin on the Progression of Chronic Kidney Disease
Aponte Becerra L, Turner JM. A commentary on: Effects of empagliflozin on progression of chronic kidney disease: a prespecified secondary analysis from the empa-kidney trial. PracticeUpdate website.Commentaries, Editorials and Letters
2023
Relationships among Non-Neoplastic Histopathological Features, Kidney Function, Proteinuria, and Other Clinical Factors in Patients Undergoing Nephrectomy
Becerra L, Betancourt J, Elfassy T, Iakymenko O, Thomas D, Isaac F, Fornoni A, Zuo Y, Barisoni L, Contreras G, Mendoza J. Relationships among Non-Neoplastic Histopathological Features, Kidney Function, Proteinuria, and Other Clinical Factors in Patients Undergoing Nephrectomy. Glomerular Diseases 2023, 3: 220-229. PMID: 37915860, PMCID: PMC10616670, DOI: 10.1159/000534339.Peer-Reviewed Original ResearchLower eGFRGlobal glomerulosclerosisInterstitial fibrosisCardiovascular diseaseClinical factorsHistopathological featuresSpecific histopathological featuresGlomerular filtration rateCross-sectional analysisDipstick proteinuriaKidney functionMultivariable analysisFiltration rateKidney parenchymaOutcome measuresProteinuriaRoutine examinationHypertensionPatientsArteriosclerosisEGFRNephrectomyObesityAssociationRegression modelsDaily intranasal insulin at 40IU does not affect food intake and body composition: A placebo-controlled trial in older adults over a 24-week period with 24-weeks of follow-up
Becerra L, Gavrieli A, Khan F, Novak P, Lioutas V, Ngo L, Novak V, Mantzoros C. Daily intranasal insulin at 40IU does not affect food intake and body composition: A placebo-controlled trial in older adults over a 24-week period with 24-weeks of follow-up. Clinical Nutrition 2023, 42: 825-834. PMID: 37084469, PMCID: PMC10330069, DOI: 10.1016/j.clnu.2023.04.008.Peer-Reviewed Original ResearchConceptsBody mass indexType 2 diabetesIntranasal insulinSecondary outcomesFood intakeBody compositionType 2 diabetes trialsOlder adultsPlacebo-controlled studyPlacebo-controlled trialDiabetes (ACCORD) trialPrimary outcomeIntervention visitsMass indexBody fatAnthropometric measuresAnimal studiesBody weightHigh dosesInteraction of treatmentEnergy homeostasisDiabetesInsulinWeight lossAppetiteOne-year all-cause mortality in hospitalized patients with COVID-19 and end-stage renal disease undergoing hemodialysis.
Munoz Mendoza J, Aponte-Becerra L, Torres C, Rozas J, Francois P, Salcedo J, Barreto A, Rodriguez J, Suarez M, Fornoni A, Contreras G. One-year all-cause mortality in hospitalized patients with COVID-19 and end-stage renal disease undergoing hemodialysis. Clinical Nephrology 2023, 99: 51-57. PMID: 36519940, DOI: 10.5414/cn110823.Peer-Reviewed Original ResearchConceptsEnd-stage renal diseaseCOVID-19 infectionLong-term mortality riskHospital mortalityMortality riskRenal diseaseOdds ratioCOVID-19Higher long-term mortality riskRetrospective chart reviewAdjusted odds ratioLogistic regression modelsESRD patientsCause mortalitySecondary outcomesChart reviewPrimary outcomeHospitalized patientsHigher oddsMortality ratePatientsMortalityOne-yearInfectionSignificant differences
2022
Depressive symptoms exacerbate disability in older adults: A prospective cohort analysis of participants in the MemAID trial
Buss S, Becerra L, Trevino J, Fortier C, Ngo L, Novak V. Depressive symptoms exacerbate disability in older adults: A prospective cohort analysis of participants in the MemAID trial. PLOS ONE 2022, 17: e0278319. PMID: 36445876, PMCID: PMC9707770, DOI: 10.1371/journal.pone.0278319.Peer-Reviewed Original ResearchConceptsDepressive symptomsImportant modifiable risk factorOlder adultsWeek 48 visitModifiable risk factorsProspective cohort analysisEffect of comorbiditySelf-reported disabilityType 2 diabetesGeriatric Depression ScalePublic health priorityIntranasal insulinMedical comorbiditiesCardiovascular mortalityGait speedRisk factorsClinical trialsNormal limitsWeek 25Depression ScaleHealth priorityCohort analysisComorbiditiesWorse cognitionCognitive decline