Khaled Alok, MD, MBA
InstructorAbout
Research
Publications
2026
Our 30 Year Experience Utilizing Hydroxyapatite Cement (HAC) in Cranial Surgery: Applications, Outcomes, and Considerations
Cottrell J, Alok K, Moliterno J, Kveton J. Our 30 Year Experience Utilizing Hydroxyapatite Cement (HAC) in Cranial Surgery: Applications, Outcomes, and Considerations. Journal Of Neurological Surgery Part B Skull Base 2026, 87: s1-s548. DOI: 10.1055/s-0046-1819235.Peer-Reviewed Original Research
2025
Long-term seizure and functional outcomes following peri-insular hemispherotomy
Moussa B, Alok K, Nawfal O, Najjar M, Farhat S, Beydoun A. Long-term seizure and functional outcomes following peri-insular hemispherotomy. Epilepsy & Behavior 2025, 173: 110801. PMID: 41175666, DOI: 10.1016/j.yebeh.2025.110801.Peer-Reviewed Original ResearchConceptsPeri-insular hemispherotomyLong-term seizureSeizure recurrenceFunctional outcomesEngel class I outcomePredictors of seizure recurrenceWada testAmerican University of Beirut Medical CenterContralateral seizure onsetLate seizure recurrenceClass I outcomeMiddle Eastern cohortSeizure-free yearsNo relapseEngel classificationIncomplete disconnectionPostoperative surveillanceSeizure outcomeEpileptiform dischargesSeizure freedomSurgical eligibilityUnilateral onsetFollow-upInterictal dischargesEastern cohortEvolving Treatment Paradigms of Meningiomas; a Precision Medicine Perspective
Galluzzo D, Chen C, Alok K, Moliterno J, Kurz S. Evolving Treatment Paradigms of Meningiomas; a Precision Medicine Perspective. Current Neurology And Neuroscience Reports 2025, 25: 69. PMID: 41085787, DOI: 10.1007/s11910-025-01461-3.Peer-Reviewed Original ResearchConceptsCentral nervous systemWHO classificationMedical managementDirection of targeted therapyWHO classification of tumorsCentral nervous system tumorsManagement of meningiomasMaximal safe resectionMultidisciplinary management strategyNervous system tumorsClassification of tumorsRadiotherapy strategiesSafe resectionSystemic therapyIntracranial meningiomasRecurrent casesTargeted therapyTumor typesSystem tumorsSurgical techniqueMolecular alterationsHigh-gradeClinical challengeMeningioma gradeMeningiomasIntraoperative neurovascular considerations for efficient intraventricular meningioma surgery: illustrative case
Alok K, Ocampo-Navia M, Yaşar B, Chavez M, Elsamadicy A, Moliterno J. Intraoperative neurovascular considerations for efficient intraventricular meningioma surgery: illustrative case. Journal Of Neurosurgery Case Lessons 2025, 9: case2569. PMID: 40523341, PMCID: PMC12171106, DOI: 10.3171/case2569.Peer-Reviewed Original ResearchIntraventricular meningiomasTumor devascularizationArterial feedersBrain retractionTemporary clippingGross-total tumor resectionProximity to critical neurovascular structuresTemporal horn entrapmentGross-total resectionTreatment of choiceSubtypes of brain tumorsCritical neurovascular structuresIntraoperative neurophysiological monitoringPreoperative embolizationIntraventricular tumorsTumor resectionVentricular obstructionBlood lossMeningioma surgerySurgical strategyTranssulcal approachNeurophysiological monitoringResectionIntracranial pressureTumorOperative Time as a Modifiable Risk Factor for Skull Base Surgical Morbidity: A Literature Review
Alok K, Chavez M, Dincer A, Moliterno J. Operative Time as a Modifiable Risk Factor for Skull Base Surgical Morbidity: A Literature Review. Journal Of Neurological Surgery Part B Skull Base 2025, 86: s1-s576. DOI: 10.1055/s-0045-1803872.Peer-Reviewed Original Research
2024
CGRP as a potential mediator for the sexually dimorphic responses to traumatic brain injury
Li C, Ajmal E, Alok K, Powell K, Wadolowski S, Tambo W, Turpin J, Barthélemy E, Al-Abed Y, LeDoux D. CGRP as a potential mediator for the sexually dimorphic responses to traumatic brain injury. Biology Of Sex Differences 2024, 15: 44. PMID: 38816868, PMCID: PMC11138127, DOI: 10.1186/s13293-024-00619-x.Peer-Reviewed Original ResearchConceptsTraumatic brain injuryChronic phase of traumatic brain injuryPhase of traumatic brain injuryTraumatic brain injury outcomesCalcitonin gene-related peptideBrain injuryDepression-like behaviorFemale ratsCalcitonin gene-related peptide inhibitionCalcitonin gene-related peptide expressionEndothelial nitric oxide synthaseOutcome of traumatic brain injuryBrain sub-regionsSexually dimorphic responseSevere traumatic brain injuryAnxiety-likeElevated levels of calcitonin gene-related peptideFemale sex hormonesSpatial memoryChronic phaseResultsFemale ratsNeuroprotective effectsCortical impactDimorphic responseBiological sexBioelectronic medicine in modulation of cortical spreading depolarization and beyond
Alok K, White T, Li C. Bioelectronic medicine in modulation of cortical spreading depolarization and beyond. Neural Regeneration Research 2024, 20: 481-482. PMID: 38819057, PMCID: PMC11317948, DOI: 10.4103/nrr.nrr-d-23-02059.Peer-Reviewed Original ResearchBrivaracetam-Associated Rhabdomyolysis Requiring Renal Replacement Therapy: A Case Report and Review of the Literature
Alok K, Lin A, Dematteo C, Abrar H, Levy Z. Brivaracetam-Associated Rhabdomyolysis Requiring Renal Replacement Therapy: A Case Report and Review of the Literature. Cureus 2024, 16: e58183. PMID: 38741805, PMCID: PMC11089833, DOI: 10.7759/cureus.58183.Peer-Reviewed Original ResearchFavorable adverse event profileSerum creatine kinase levelsCreatine kinase peakAdverse event profileSide effect profileCase of rhabdomyolysisCreatine kinase levelsRare adverse reactionLife-threatening rhabdomyolysisAssociation of rhabdomyolysisAdverse Event Reporting SystemSynaptic vesicle glycoprotein 2AEvent Reporting SystemEvent profileLevetiracetam useEffect profileCase reportAntiseizure medicationsKinase levelsAdverse reactionsRhabdomyolysisBrivaracetamLevetiracetamCurrent dataSV2ASuperficial Temporal Artery-to-Middle Cerebral Artery Bypass in Ischemic Stroke With Blood Pressure-Dependent Symptoms
Huang B, Huang C, Alok K, Chen A. Superficial Temporal Artery-to-Middle Cerebral Artery Bypass in Ischemic Stroke With Blood Pressure-Dependent Symptoms. Cureus 2024, 16: e56236. PMID: 38618338, PMCID: PMC11016294, DOI: 10.7759/cureus.56236.Peer-Reviewed Original ResearchSuperficial temporal artery-to-middle cerebral arteryEC-IC bypassSingle photon emission CTSuperficial temporal artery-to-middle cerebral artery bypassNational Institutes of Health Stroke ScaleMiddle cerebral arteryEC-ICTranscranial Doppler ultrasoundCT perfusionHemodynamic insufficiencyCerebral arteryPatient's National Institutes of Health Stroke ScaleCT perfusion imagingExtracranial-intracranial (EC-IC) bypassHealth Stroke ScaleArtery bypassNeurological deficitsEmission CTRight hemiparesisDoppler ultrasoundCore infarctIschemic stroke progressionStroke progressionIschemic penumbraCerebral flow
2023
E-251 Unusual course of the facial vein encountered during direct carotid cavernous fistula embolization
Alok K, Salame J. E-251 Unusual course of the facial vein encountered during direct carotid cavernous fistula embolization. 2023, a228-a228. DOI: 10.1136/jnis-2023-snis.350.Peer-Reviewed Original Research
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Yale School of Medicine
Department of Neurosurgery, 310 Cedar St.
New Haven, CT 06520
United States