Kevin Sevarino, MD
About
Appointments
Education & Training
- MD
- McGill University (1982)
Research
Research at a Glance
Publications Timeline
A big-picture view of Kevin Sevarino's research output by year.
4Publications
95Citations
Publications
2023
Disorders Due to Substance Use: Stimulants
Sevarino K, Farrell M. Disorders Due to Substance Use: Stimulants. 2023, 1-90. DOI: 10.1007/978-3-030-42825-9_26-1.Peer-Reviewed Original ResearchConceptsBody of preclinical researchAssociated with significant impairmentStimulant use disorderFDA-approved medicationsBehavioral therapyOccupational functioningUse disorderPrescribed stimulantsSignificant impairmentHepatitis CClinical featuresSubstance usePharmacological therapyMedical illnessPreclinical researchRates of overdose deathsCardiovascular diseaseDisordersElevated ratesElevated riskTherapyPotential targetOverdose deathsStimulationAdverse consequences
1999
The Biology of pro-Thyrotropin-Releasing Hormone-Derived Peptides*
Nillni E, Sevarino K. The Biology of pro-Thyrotropin-Releasing Hormone-Derived Peptides*. Endocrine Reviews 1999, 20: 599-648. PMID: 10529897, DOI: 10.1210/edrv.20.5.0379.Peer-Reviewed Original ResearchCitations
1993
Identification of the thyrotropin-releasing hormone-prohormone and its posttranslational processing in a transfected AtT20 tumoral cell line
Nillni E, Sevarino K, Jackson I. Identification of the thyrotropin-releasing hormone-prohormone and its posttranslational processing in a transfected AtT20 tumoral cell line. Endocrinology 1993, 132: 1260-1270. DOI: 10.1210/en.132.3.1260.Peer-Reviewed Original ResearchCitationsAltmetricConceptsSodium dodecyl sulfate-polyacrylamide gel electrophoresisCryptic peptidesDodecyl sulfate-polyacrylamide gel electrophoresisSulfate-polyacrylamide gel electrophoresisAtT20 cell lineCell linesPulse-chase studiesN-terminal fragmentGel filtration chromatographyCarboxy-terminalCell extractsGel electrophoresisPulse-chaseTRH progenitor sequenceProgenitor sequencePosttranslational processingWestern blot analysisAmino acidsBiosynthetic precursorFiltration chromatographyBlot analysisTumor cell linesGln-His-Pro-GlySequenceProTRH-derived peptidesProcessing of proTRH to its intermediate products occurs before the packing into secretory granules of transfected AtT20 cells
Nillni E, Sevarino K, Jackson I. Processing of proTRH to its intermediate products occurs before the packing into secretory granules of transfected AtT20 cells. Endocrinology 1993, 132: 1271-1277. DOI: 10.1210/en.132.3.1271.Peer-Reviewed Original ResearchCitationsAltmetricConceptsPulse-chase studiesProcessing of proTRHSecretory granulesAtT20 cellsAssay of marker enzymesPolyacrylamide gel electrophoresisPulse-chase experimentsCryptic peptidesC-terminal processing productsNitrogen cavitationSubcellular compartmentsSG fractionGel electrophoresisRER fractionPosttranslational processingSubcellular fractionsIntracellular compartmentsPurified antibodiesProTRH processingIntermediate processing productsGolgiIntact precursorMarker enzymesPeptideProcessing products