Kene Mezue, MD, MSc
Clinical FellowAbout
Research
Publications
2026
26-A-18565-ACC IMPLEMENTATION OF A TRANSNATIONAL PHYSICIAN ELECTROCARDIOGRAM INTERPRETATION PROGRAM TO IMPROVE CARDIOVASCULAR CARE ACCESS IN RURAL JAMAICA
Brown X, Mezue K, ARIZE C, Hibbert R, Dolphin J, Smith P, Kattan C, Tabtabai S, De Freitas C, Miller E, Madu E. 26-A-18565-ACC IMPLEMENTATION OF A TRANSNATIONAL PHYSICIAN ELECTROCARDIOGRAM INTERPRETATION PROGRAM TO IMPROVE CARDIOVASCULAR CARE ACCESS IN RURAL JAMAICA. Journal Of The American College Of Cardiology 2026, 87: a1227. DOI: 10.1016/j.jacc.2026.02.3020.Peer-Reviewed Original Research26-A-17533-ACC ESTIMATES OF JAMAICAN TRANSTHYRETIN AMYLOID CARDIOMYOPATHY (ATTR-CM) PREVALENCE USING DUAL ARTIFICIAL INTELLIGENCE (AI) ELECTROCARDIOGRAM (ECG) AND ECHOCARDIOGRAM (ECHO) MODELS
Hibbert R, Brown X, ARIZE C, Williams C, De Freitas C, Reid K, Thangaraj P, Adefuye M, Mezue K, Haynes N, Tabtabai S, Kattan C, Oikonomou E, Khera R, Madu E, Miller E. 26-A-17533-ACC ESTIMATES OF JAMAICAN TRANSTHYRETIN AMYLOID CARDIOMYOPATHY (ATTR-CM) PREVALENCE USING DUAL ARTIFICIAL INTELLIGENCE (AI) ELECTROCARDIOGRAM (ECG) AND ECHOCARDIOGRAM (ECHO) MODELS. Journal Of The American College Of Cardiology 2026, 87: a1226. DOI: 10.1016/j.jacc.2026.02.3017.Peer-Reviewed Original Research26-A-19178-ACC ECHOCARDIOGRAPHIC PHENOTYPING OF AFRO-CARIBBEAN PATIENTS WITH CONGESTIVE HEART FAILURE FROM A JAMAICAN TERTIARY CARE CARDIOLOGY CENTER
Hibbert R, Brown X, ARIZE C, Williams C, De Freitas C, Mezue K, Tabtabai S, Haynes N, Kattan C, Madu E, Miller E. 26-A-19178-ACC ECHOCARDIOGRAPHIC PHENOTYPING OF AFRO-CARIBBEAN PATIENTS WITH CONGESTIVE HEART FAILURE FROM A JAMAICAN TERTIARY CARE CARDIOLOGY CENTER. Journal Of The American College Of Cardiology 2026, 87: a773-a774. DOI: 10.1016/j.jacc.2026.02.1999.Peer-Reviewed Original ResearchPO-04-313 DIAGNOSTIC ACCURACY OF WEARABLE DEVICES VERSUS HOLTER MONITORING FOR ASYMPTOMATIC ATRIAL FIBRILLATION: A SYSTEMATIC REVIEW AND META-ANALYSIS
Nwevo C, Ogza D, Busari O, Etuk A, Markson F, Odigwe C, Mezue K, Hegde S. PO-04-313 DIAGNOSTIC ACCURACY OF WEARABLE DEVICES VERSUS HOLTER MONITORING FOR ASYMPTOMATIC ATRIAL FIBRILLATION: A SYSTEMATIC REVIEW AND META-ANALYSIS. Heart Rhythm 2026, 23: s769. DOI: 10.1016/j.hrthm.2026.03.1310.Peer-Reviewed Original Research
2025
Atrial Fibrillation Ablation: A Healthy Investment Even With Some Upfront Cost
Mezue K, Rosenfeld L. Atrial Fibrillation Ablation: A Healthy Investment Even With Some Upfront Cost. The American Journal Of Cardiology 2025, 254: 147-148. PMID: 40571171, DOI: 10.1016/j.amjcard.2025.06.016.Peer-Reviewed Original Research
2024
Anxiety and depression are associated with heightened risk of incident deep vein thrombosis: Mediation through stress‐related neural mechanisms
Rosovsky R, Mezue K, Gharios C, Civieri G, Cardeiro A, Zureigat H, Lau H, Pitman R, Shin L, Abohashem S, Osborne M, Jaffer F, Tawakol A. Anxiety and depression are associated with heightened risk of incident deep vein thrombosis: Mediation through stress‐related neural mechanisms. American Journal Of Hematology 2024, 99: 1927-1938. PMID: 38965839, PMCID: PMC11502251, DOI: 10.1002/ajh.27427.Peer-Reviewed Original ResearchTreatment of anxietyAssociated with heightened riskDeep vein thrombosisNeural mechanismsHeart rate variabilityAutonomic system activityMediation analysisVein thrombosisHs-CRPNeural activityAnxietyDepressionCortical activityIncident deep vein thrombosisF-FDG PET/CT imagingHigh-sensitivity C-reactive proteinFemale participantsMedian Follow-UpC-reactive proteinDVT risk factorsMedian ageMass General Brigham BiobankRetrospective studyChronic inflammationFollow-upEffect of Stress-Related Neural Pathways on the Cardiovascular Benefit of Physical Activity
Zureigat H, Osborne M, Abohashem S, Mezue K, Gharios C, Grewal S, Cardeiro A, Naddaf N, Civieri G, Abbasi T, Radfar A, Aldosoky W, Seligowski A, Wasfy M, Guseh J, Churchill T, Rosovsky R, Fayad Z, Rosenzweig A, Baggish A, Pitman R, Choi K, Smoller J, Shin L, Tawakol A. Effect of Stress-Related Neural Pathways on the Cardiovascular Benefit of Physical Activity. Journal Of The American College Of Cardiology 2024, 83: 1543-1553. PMID: 38631773, PMCID: PMC11164527, DOI: 10.1016/j.jacc.2024.02.029.Peer-Reviewed Original ResearchConceptsCardiovascular disease eventsPhysical activityCardiovascular diseaseCVD riskBenefits of physical activityMass General Brigham BiobankElectronic health recordsIncident CVD eventsReduce CVD riskDecrease CVDCardiovascular disease riskPA surveyGreater PANeural activityPA benefitsHealth recordsPotential cardiovascular diseaseCVD eventsPreexisting depressionGuideline recommendationsStress-related activationCardiovascular disease benefitMultivariate modelDepressionNeural effectsClinical Biochemistry of Serum Troponin
Gokhan I, Dong W, Grubman D, Mezue K, Yang D, Wang Y, Gandhi P, Kwan J, Hu J. Clinical Biochemistry of Serum Troponin. Diagnostics 2024, 14: 378. PMID: 38396417, PMCID: PMC10887818, DOI: 10.3390/diagnostics14040378.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsAcute coronary syndromeFalse negative test resultsPoint of care assayInterpretation of serum levelsNegative test resultsTroponin complexChest painInterpretation of assay resultsSerum levelsClinical workupCoronary syndromeTn assaysMyocardial injuryTest characteristicsClinical settingCare assaysTroponinMeasurement assaysMolecular characteristicsPotential causesAssay resultsAssayMolecular structureFalse resultsConstituent proteins
2023
Reply Causal Pathway of Alcohol Intake: Stress-Related Neuronal Activity and Cardiovascular Risk
Mezue K, Abohashem S, Osborne M, Tawakol A. Reply Causal Pathway of Alcohol Intake: Stress-Related Neuronal Activity and Cardiovascular Risk. Journal Of The American College Of Cardiology 2023, 82: e227-e228. PMID: 38030356, PMCID: PMC10752352, DOI: 10.1016/j.jacc.2023.09.825.Commentaries, Editorials and LettersUneven burden of cardiac amyloidosis in people of African descent — global imbalance in resources and access
Madu E, Mezue K. Uneven burden of cardiac amyloidosis in people of African descent — global imbalance in resources and access. BMC Global And Public Health 2023, 1: 15. PMID: 39681929, PMCID: PMC11622854, DOI: 10.1186/s44263-023-00016-3.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsTTR-CABlack populationHealthcare financing mechanismsPublic health budgetsCardiac amyloidosisGlobal health equityAt-risk populationsHeart failureHealth literacyHealth equityHealth workersTransthyretin cardiac amyloidosisHealth budgetDiastolic heart failureImprove accessPoor awarenessWest African ancestryDisease RegistryCenters of excellenceInternational Center of ExcellenceUneven burdenFinancial remunerationCaribbean populationGenetic basisAfrican ancestry