John Chang, MD
Associate Professor of Medicine (General Medicine)Cards
About
Research
Publications
2024
Risk of Serious Adverse Gastrointestinal Events with Potassium Binders in Hospitalized Patients: A National Study
Holleck J, Han L, Skanderson M, Bastian L, Gunderson C, Brandt C, Perkal M, Chang J, Akgün K. Risk of Serious Adverse Gastrointestinal Events with Potassium Binders in Hospitalized Patients: A National Study. Journal Of General Internal Medicine 2024, 40: 518-524. PMID: 39103605, PMCID: PMC11861845, DOI: 10.1007/s11606-024-08979-1.Peer-Reviewed Original ResearchAdjusted odds ratiosSodium zirconium cyclosilicateU.S. Department of Veterans Affairs healthcare systemDepartment of Veterans Affairs healthcare systemVA Corporate Data WarehouseVeterans Affairs Healthcare SystemCorporate Data WarehousePotassium bindersHospitalized patientsGI eventsHealthcare systemOdds ratioAdverse GI eventsSodium polystyrene sulfonateNational studyPotassium-binding drugsComparative riskAdverse gastrointestinal eventsGI adverse eventsTreatment of hyperkalemiaZirconium cyclosilicateGastrointestinal eventsPatiromerAdverse eventsASSOCIATIONS OF ULTRA LONG-TERM VISIT-TO-VISIT BLOOD PRESSURE VARIABILITY SINCE CHILDHOOD WITH VASCULAR AGING IN MIDLIFE: A 30-YEAR PROSPECTIVE COHORT STUDY
Wang Y, -Ma A, Zhao P, Chu C, Du M, Wang D, Jia H, Hu G, Ma Q, Yan Y, Chang J, Delles C, Chen F, Mu J. ASSOCIATIONS OF ULTRA LONG-TERM VISIT-TO-VISIT BLOOD PRESSURE VARIABILITY SINCE CHILDHOOD WITH VASCULAR AGING IN MIDLIFE: A 30-YEAR PROSPECTIVE COHORT STUDY. Journal Of Hypertension 2024, 42: e11. DOI: 10.1097/01.hjh.0001019424.08488.b4.Peer-Reviewed Original ResearchLong-term BP variabilityPresence of carotid plaqueBlood pressureAverage real variabilityArterial stiffnessBP variabilityCarotid hypertrophyMean BPCarotid plaquesSubpopulation treatment effect pattern plot methodologyVascular agingFunctional arterial propertiesYears of follow-upAssociated with arterial stiffnessPredictor of cardiovascular diseaseHigher BP variabilityPredictor of cardiovascular outcomesLong-term blood pressureAssociated with riskExposure to BPParticipants aged 6Clinical characteristicsFollow-upCohort studyCardiovascular outcomesASSOCIATION OF LONG-TERM TIME IN TARGET RANGE FOR SYSTOLIC BLOOD PRESSURE SINCE CHILDHOOD WITH ARTERIAL STIFFNESS IN MIDLIFE: A 36-YEAR PROSPECTIVE COHORT STUDY
Wang Y, Qi H, Jia H, Wang D, Sun Y, Du M, Hu G, Man Z, Chu C, Chang J, Delles C, Zhang L, Mu J. ASSOCIATION OF LONG-TERM TIME IN TARGET RANGE FOR SYSTOLIC BLOOD PRESSURE SINCE CHILDHOOD WITH ARTERIAL STIFFNESS IN MIDLIFE: A 36-YEAR PROSPECTIVE COHORT STUDY. Journal Of Hypertension 2024, 42: e54. DOI: 10.1097/01.hjh.0001019768.43096.d1.Peer-Reviewed Original ResearchRisk of arterial stiffnessSystolic blood pressureOdds ratioDecreased riskArterial stiffness in adulthoodAssociated with adult hypertensionRisk factorsModifiable risk factorsAdolescents aged 6Arterial stiffnessBlood pressureYears of follow-upCardiovascular risk factorsTraditional cardiovascular risk factorsAssociated with arterial stiffnessElevated blood pressureLowest quartileSystolic blood pressure variabilityCohort studyAged 6MidlifeTarget rangeCardiovascular diseaseAdult hypertensionTime-in-target
2023
Empagliflozin in Heart Failure: Regional Nephron Sodium Handling Effects
Rao V, Ivey-Miranda J, Cox Z, Moreno-Villagomez J, Maulion C, Bellumkonda L, Chang J, Field M, Wiederin D, Butler J, Collins S, Turner J, Wilson F, Inzucchi S, Wilcox C, Ellison D, Testani J. Empagliflozin in Heart Failure: Regional Nephron Sodium Handling Effects. Journal Of The American Society Of Nephrology 2023, 35: 189-201. PMID: 38073038, PMCID: PMC10843196, DOI: 10.1681/asn.0000000000000269.Peer-Reviewed Original ResearchEARLY LIFE CARDIOVASCULAR RISK FACTOR TRAJECTORIES AND VASCULAR AGING IN MIDLIFE: A 30-YEAR PROSPECTIVE COHORT STUDY
Wang Y, Wang J, Du M, Zhang X, Chu C, Wang D, Liao Y, Ma Q, Jia H, Hu G, Yan Y, Sun Y, Chang J, Delles C, Lu Y, Mu J. EARLY LIFE CARDIOVASCULAR RISK FACTOR TRAJECTORIES AND VASCULAR AGING IN MIDLIFE: A 30-YEAR PROSPECTIVE COHORT STUDY. Journal Of Hypertension 2023, 41: e20. DOI: 10.1097/01.hjh.0000939064.62089.c3.Peer-Reviewed Original ResearchBrachial-ankle pulse wave velocityCarotid intima-media thicknessSystolic blood pressureBody mass indexIndividual cardiovascular risk factorsCardiovascular risk factorsVascular agingHeart rateRisk factorsHanzhong Adolescent Hypertension StudyDistinct BMI trajectoriesFunctional arterial propertiesRisk factor accumulationProspective cohort studyIntima-media thicknessPulse wave velocityRisk factor trajectoriesGroup-based trajectory modelingCardiovascular outcomesOngoing cohortCohort studyBlood pressureIndependent predictorsMass indexSBP trajectoriesAssociations of SGLT2 genetic polymorphisms with salt sensitivity, blood pressure changes and hypertension incidence in Chinese adults
Jia H, Bao P, Yao S, Zhang X, Mu J, Hu G, Du M, Chu C, Zhang X, Wang L, Liao Y, Wang D, Ma Q, Yan Y, Niu Z, Gao W, Li H, Wu G, Chang J, Wang Y. Associations of SGLT2 genetic polymorphisms with salt sensitivity, blood pressure changes and hypertension incidence in Chinese adults. Hypertension Research 2023, 46: 1795-1803. PMID: 37160967, DOI: 10.1038/s41440-023-01301-2.Peer-Reviewed Original ResearchConceptsLongitudinal BP changesLow-salt dietDevelopment of hypertensionBlood pressureHypertension incidenceBP changesSodium-glucose cotransporter 2 inhibitorsSalt sensitivityCotransporter 2 inhibitorsIncidence of hypertensionHigh-salt dietSystolic blood pressureBlood pressure changesGenetic polymorphismsIncident hypertensionSystolic BPDietary interventionSBP changeUsual dietHypertensionChinese adultsSalutary effectsIncidenceDietSGLT2Reducing Nighttime Interruptions and Improving Sleep for Hospitalized Patients by Restructuring Nighttime Clinical Workflow
Holleck M, Tikkanen K, Holleck J, Frank C, Falco N, Cosentino D, Chang J. Reducing Nighttime Interruptions and Improving Sleep for Hospitalized Patients by Restructuring Nighttime Clinical Workflow. Journal Of General Internal Medicine 2023, 38: 2091-2097. PMID: 36697927, PMCID: PMC10361944, DOI: 10.1007/s11606-022-08005-2.Peer-Reviewed Original ResearchConceptsBlood pressure checkPressure checkHospitalized patientsSleep disruptionClinical workflowNighttime sleep disruptionsVenous thromboembolism prophylaxisGeneral medical wardsPercentage of patientsCross-sectional studyVeterans Administration HospitalWorse sleep qualityKey ResultsAfterNocturnal disruptionsTelemetry patientsThromboembolism prophylaxisMedical wardsImproved sleepMedication administrationAdministration HospitalSleep qualityPatientsNighttime disruptionsSleep surveyHospital
2019
MON-334 TWO FORMS OF RENALASE (BOUND AND FREE) IDENTIFIED IN HUMAN PLASMA BY A NEW ELISA
Rao V, Guo X, Chang J, Peixoto A, Testani J, Desir G. MON-334 TWO FORMS OF RENALASE (BOUND AND FREE) IDENTIFIED IN HUMAN PLASMA BY A NEW ELISA. Kidney International Reports 2019, 4: s67. DOI: 10.1016/j.ekir.2019.05.180.Peer-Reviewed Original ResearchSAT-183 % FREE RENALASE IS ASSOCIATED WITH PROGRESSION OF CKD, AND IS AN INDEPENDENT PREDICTOR OF ALL CAUSE MORTALITY
Desir G, Chang J, Guo X, Gromisch E, Peixoto A. SAT-183 % FREE RENALASE IS ASSOCIATED WITH PROGRESSION OF CKD, AND IS AN INDEPENDENT PREDICTOR OF ALL CAUSE MORTALITY. Kidney International Reports 2019, 4: s84-s85. DOI: 10.1016/j.ekir.2019.05.217.Peer-Reviewed Original Research
Academic Achievements & Community Involvement
Clinical Care
Overview
John Chang, MD, is a nephrologist specializing in conditions that disrupt involuntary bodily processes, such as pure autonomic failure, autonomic dysreflexia, and postural orthostatic tachycardia syndrome (POTS). He also performs innovative treatments like fecal transplants and bacteriotherapy to manage fecal incontinence issues.
Dr. Chang’s research interests include cardiovascular health and vascular aging, blood pressure and hypertension, sleep quality in hospitalized patients, and genetic factors in health outcomes. His work examines the correlation between specific proteins and genes with blood pressure fluctuations, hypertension, and salt sensitivity.
A recipient of several teaching awards, including the Hughes Award for Teaching at the Veterans Affairs (VA) Healthcare System, the Asghar Rastegar Award for Teacher of the Year at the VA Healthcare System, and the Society of Hospital Medicine Connecticut Chapter Award of Excellence in Teaching, Dr. Chang is an associate professor of medicine at Yale School of Medicine.
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Nephrology
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