John D Roberts, MD
Professor of Internal MedicineCards
Appointments
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Professor of Internal Medicine
Biography
Dr Roberts has worked at the University of Vermont, Virginia Commonwealth University, and Yale University. He is board certified in internal medicine, pediatrics, medical oncology, and hospice and palliative care. He did laboratory and clinical research, including scores of clinical trials, while practicing medical oncology and caring for adults with sickle cell disease. He has done research administration, academic administration, and served on multiple IRBs. He has served on committees of the American Society of Hematology, the American Society of Clinical Oncology, and the National Institutes of Health. Current activities are clinical research and consulting for non-governmental organizations and the pharmaceutical and pharmacy industries.
Appointments
Medical Oncology and Hematology
ProfessorPrimary
Other Departments & Organizations
- Developmental Therapeutics
- Hematology
- Internal Medicine
- Medical Oncology and Hematology
Education & Training
- Fellow
- University of Vermont (1984)
- Resident
- University of North Carolina at Chapel Hill (1980)
- MD
- University of Pennsylvania (1976)
- AB
- Harvard University, Social Studies (1972)
Board Certifications
Medical Oncology
- Certification Organization
- AB of Internal Medicine
- Original Certification Date
- 1985
Pediatrics
- Certification Organization
- AB of Pediatrics
- Original Certification Date
- 1982
Internal Medicine
- Certification Organization
- AB of Internal Medicine
- Original Certification Date
- 1980
Research
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Overview
Medical Research Interests
ORCID
0000-0003-2020-6201
Research at a Glance
Yale Co-Authors
Publications Timeline
Research Interests
Joanna Cole, RN, APRN, FNP (BC)
Alexa Siddon, MD
Ariadna Forray, MD
Christopher Tormey, MD
Daniel Zelterman, PhD
Jeanne Hendrickson, MD
Anemia, Sickle Cell
Publications
2021
Non-crisis related pain occurs in adult patients with sickle cell disease despite chronic red blood cell exchange transfusion therapy
Curtis SA, Raisa BM, Roberts JD, Hendrickson JE, Starrels J, Lesley D, Michelle D, Daniel Z, Brandow AM. Non-crisis related pain occurs in adult patients with sickle cell disease despite chronic red blood cell exchange transfusion therapy. Transfusion And Apheresis Science 2021, 61: 103304. PMID: 34782244, PMCID: PMC9838733, DOI: 10.1016/j.transci.2021.103304.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsChronic exchange transfusionsHealth care utilizationCare utilizationExchange transfusionPain impactDisease characteristicsChronic red blood cell transfusionsRed blood cell transfusionLower health care utilizationSickle Cell Disease PainExchange transfusion therapyAcute care utilizationBlood cell transfusionSimilar disease characteristicsPatient-reported outcomesLength of staySickle cell diseaseQuality of lifeCause admissionsCell transfusionNeuropathic painOpioid prescriptionsWorst painAcute painAdult patients
2020
Phase 1 study of belinostat (PXD-101) and bortezomib (Velcade, PS-341) in patients with relapsed or refractory acute leukemia and myelodysplastic syndrome
Holkova B, Shafer D, Yazbeck V, Dave S, Bose P, Tombes MB, Shrader E, Wan W, Bandyopadhyay D, Weir C, Collins EB, Garnett A, Kmieciak M, Roberts JD, Garcia-Manero G, Grant S. Phase 1 study of belinostat (PXD-101) and bortezomib (Velcade, PS-341) in patients with relapsed or refractory acute leukemia and myelodysplastic syndrome. Leukemia & Lymphoma 2020, 62: 1187-1194. PMID: 33356689, PMCID: PMC8106643, DOI: 10.1080/10428194.2020.1861270.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsStable diseaseAcute leukemiaDay 1Phase 1 dose-escalation studyRefractory acute leukemiaDose-escalation studyPhase 1 studyWhole-exome sequencingComplete pathologicKaryotypic responseAdult patientsQTc prolongationFirst patientMyelodysplastic syndromeTreatment strategiesBlast crisisPatientsExceptional responseKaryotypic aberrationsBelinostatGood responseBortezomibAMLLeukemiaFurther investigationDaily Cannabis Users with Sickle Cell Disease Show Fewer Admissions than Others with Similar Pain Complaints
Curtis SA, Brandow AM, DeVeaux M, Zeltermam D, Devine L, Roberts JD. Daily Cannabis Users with Sickle Cell Disease Show Fewer Admissions than Others with Similar Pain Complaints. Cannabis And Cannabinoid Research 2020, 5: 255-262. PMID: 32923662, PMCID: PMC7480712, DOI: 10.1089/can.2019.0036.Peer-Reviewed Original ResearchCitationsAltmetricConceptsSickle cell diseaseDaily cannabis usersAnnual emergency room visitsSevere pain crisesEmergency room visitsHealth care utilizationCannabis usersCross-sectional studyPatient-reported measuresQuality of lifeSimilar disease severityHydroxyurea usePain crisisPain complaintsHospital admissionCare utilizationRoom visitsPain impactSeverity scoreDisease showAnnual admissionsCell diseaseER useDaily cannabisDisease severityMedical marijuana certification for patients with sickle cell disease: a report of a single center experience
Curtis SA, Lew D, Spodick J, Hendrickson JE, Minniti CP, Roberts JD. Medical marijuana certification for patients with sickle cell disease: a report of a single center experience. Blood Advances 2020, 4: 3814-3821. PMID: 32790846, PMCID: PMC7448584, DOI: 10.1182/bloodadvances.2020002325.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsOpioid useMedical marijuanaSickle cell disease (SCD) reportBaseline opioid useSingle-center experienceHealth care utilizationSickle cell diseaseOpioid utilizationClinical characteristicsMost patientsCenter experienceCare utilizationSCD patientsInpatient hospitalizationRandom patientsAdmission ratesCell diseasePatientsRetrospective dataDisease reportsStudy periodHealth careCannabis productsCannabisEdible cannabis productsBuilding access to care in adult sickle cell disease: defining models of care, essential components, and economic aspects
Kanter J, Smith WR, Desai PC, Treadwell M, Andemariam B, Little J, Nugent D, Claster S, Manwani DG, Baker J, Strouse JJ, Osunkwo I, Stewart RW, King A, Shook LM, Roberts JD, Lanzkron S. Building access to care in adult sickle cell disease: defining models of care, essential components, and economic aspects. Blood Advances 2020, 4: 3804-3813. PMID: 32785684, PMCID: PMC7448595, DOI: 10.1182/bloodadvances.2020001743.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsSickle cell diseaseSCD centerCell diseaseAdult sickle cell diseaseAcute care utilizationManagement of adultsModel of careSickle cell careHealth care professionalsHealth system levelSCD guidelinesMultisystem illnessSCD careCare utilizationEarly mortalityCenter designationClinical effectivenessClinical centersCare professionalsHematology providersMore cliniciansCare deliveryMost childrenBlood disordersCareUrinary cannabinoid mass spectrometry profiles differentiate dronabinol from cannabis use
Koch CD, Xu L, Curtis SA, Roberts JD, Bunch DR, El-Khoury JM. Urinary cannabinoid mass spectrometry profiles differentiate dronabinol from cannabis use. Clinica Chimica Acta 2020, 510: 515-521. PMID: 32795544, DOI: 10.1016/j.cca.2020.08.014.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsCannabis useUrine samplesLoss of appetiteMinor cannabinoidsRapid LC-MS/MSDronabinol groupDronabinol therapyDronabinol useSevere nauseaPain managementPositive subjectsNormal controlsTherapeutic potentialProspective sampleClinical urine samplesCancer chemotherapySpecific populationsCannabisCannabinoidsMetabolite concentrationsDronabinolLC-MS/MSNegative controlDetection of cannabisCannabidiolUtilization, financial outcomes and stakeholder perspectives of a re-organized adult sickle cell program
Rousseau R, Weisberg DF, Gorero J, Parwani V, Bozzo J, Kenyon K, Smith C, Cole J, Curtis S, Forray A, Roberts JD. Utilization, financial outcomes and stakeholder perspectives of a re-organized adult sickle cell program. PLOS ONE 2020, 15: e0236360. PMID: 32706825, PMCID: PMC7380627, DOI: 10.1371/journal.pone.0236360.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsSickle cell diseaseCell diseaseYale-New Haven HospitalAcute care servicesCare of adultsPoor socio-economic statusPersonalized care planSickle Cell ProgramNew Haven HospitalSingle nursing unitParenteral opioidsPain controlClinic visitsMost patientsPain managementChronic painOutpatient visitsPrimary complaintEmergency departmentPrimary careInpatient daysCare plansCare servicesSocio-economic statusNursing units
2019
Inpatient pain management in sickle cell disease
Zassman SM, Zamora FJ, Roberts JD. Inpatient pain management in sickle cell disease. American Journal Of Health-System Pharmacy 2019, 76: 1965-1971. PMID: 31605120, DOI: 10.1093/ajhp/zxz228.Peer-Reviewed Original ResearchCitationsAltmetricConceptsVaso-occlusive crisisSickle cell diseasePatient-controlled analgesiaOral opioidsParenteral opioidsAcute painPain controlCell diseaseAverage daily pain scoreDaily pain scoresInpatient pain managementAdequate pain controlEmergency department visitsInherited blood disorderOral regimenOpioid usagePain scoresSevere painDepartment visitsHospital admissionPain managementIncremental dosesOpioidsCommon reasonPatientsRed blood cell alloimmunization is associated with lower expression of FcγR1 on monocyte subsets in patients with sickle cell disease
Balbuena‐Merle R, Curtis SA, Devine L, Gibb DR, Karafin MS, Luckey CJ, Tormey CA, Siddon AJ, Roberts JD, Hendrickson JE. Red blood cell alloimmunization is associated with lower expression of FcγR1 on monocyte subsets in patients with sickle cell disease. Transfusion 2019, 59: 3219-3227. PMID: 31355970, PMCID: PMC7075520, DOI: 10.1111/trf.15463.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsSickle cell diseaseMonocyte subsetsTotal monocytesCell diseaseComplications of SCDRed blood cell alloimmunizationRed blood cell alloantibodiesElectronic medical recordsTransfusion exposureSerum cytokinesIntermediate monocytesRBC alloantibodiesInflammatory milieuCD64 expressionClassical monocytesPeripheral bloodInflammatory functionsMedical recordsAntibody formationClinical significancePatientsMonocytesFlow cytometryLow expressionRespondersPrescription Opioid Misuse Index in sickle cell patients: A brief questionnaire to assess at-risk for opioid abuse.
Smith WR, McClish DK, Roberts JD, Kandalaft O, Dahman B, Knisely J, Levenson J, Roseff S, Aisiku IP. Prescription Opioid Misuse Index in sickle cell patients: A brief questionnaire to assess at-risk for opioid abuse. Journal Of Opioid Management 2019, 15: 323-331. PMID: 31637684, DOI: 10.5055/jom.2019.0517.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsOpioid misuseOpioid abuseAdult sickle cell disease patientsPrescription Opioid Misuse IndexSickle cell disease patientsAdult SCD patientsChronic opioid therapyGroup of patientsSickle cell clinicSickle cell patientsDiagnostic Interview ScheduleDSM-IV criteriaUrban teaching facilityOpioid therapySCD clinicOpioid usageAdult patientsRisk patientsSecondary outcomesHemoglobin SSPrimary outcomeSCD patientsMean ageDisease patientsProspective survey
Academic Achievements & Community Involvement
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Activities
activity Community Health Network of Connecticut
2014 - 2021Public ServiceConsultantDetailsWorking to improve patterns of health care services utilization by adults with Medicaid living with sickle cell disease.activity National Cancer Institute
07/01/2008 - 06/30/2012Peer Review Groups and Grant Study SectionsMemberDetailsClinical Oncology Study Section
Honors
honor 2012 Harry Hines Award (NCI CCOP Principal Investigator of the Year)
09/25/2012National AwardNational Cancer Institute
Links
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Media
colchicine in scd
Video for grant application to CuresWithinReach regarding proposed research project to re-purpose colchicine as a treatment for sickle cell disease.
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