Jessica Gois Santana
Postgraduate AssociateAbout
Research
Publications
2026
Neoadjuvant PD-1 Inhibition prior to Partial Cryoablation of Murine Hepatocellular Carcinoma Modulates the Tumor Microenvironment toward Favorable Immunological Profiles
Kao T, Santana J, Meister E, Shewarega A, Israel J, Peschke L, Tefera J, Matuschewski N, Sobirey R, Zhang X, Gebauer B, Madoff D, Savic L, Chapiro J. Neoadjuvant PD-1 Inhibition prior to Partial Cryoablation of Murine Hepatocellular Carcinoma Modulates the Tumor Microenvironment toward Favorable Immunological Profiles. Journal Of Vascular And Interventional Radiology 2026, 37: 108585. PMID: 41690670, PMCID: PMC13052828, DOI: 10.1016/j.jvir.2026.108585.Peer-Reviewed Original Researchanti-PD-1immune checkpoint inhibitionmurine hepatocellular carcinomahepatocellular carcinomacheckpoint inhibitionPD-1residual tumortumor microenvironmentT cellsTIB-75infiltration of CD3<sup>+</sup> T cellshistopathological analysisinfiltration of CD3<sup>+</sup>mouse modeladvanced-stage hepatocellular carcinomamouse model of hepatocellular carcinomaCD8<sup>+</sup> T cellspercentage of positively stained cellsCD3<sup>+</sup> T cellspresence of T-cell subsetsmodel of hepatocellular carcinomalesions of hepatocellular carcinomaimmunosuppressive tumor microenvironmentPD-1 expressionT cell subsets
2025
Liver pH imaging for diagnosis and prognosis
Santana J, Kurdi S, Chapiro J, Hyder F, Coman D. Liver pH imaging for diagnosis and prognosis. Proceedings Of The International Society For Magnetic Resonance In Medicine ... Scientific Meeting And Exhibition. 2025 DOI: 10.58530/2025/1803.Peer-Reviewed Original Researchtumor microenvironmenttumor-promoting phenotypemouse liver tumor modeltumor microenvironment acidityimmunosuppressive tumor microenvironmentdensity of immune cellsimmune T cellsliver tumor modelmouse liver tumorsliver cancer therapyphenotype of macrophagesT cellsimmune cellsliver tumorslow pHetumor modelextracellular acidosiscancer therapycytotoxic activityimmune dynamicsmetabolic characterizationtumormiceliversubmillimeter resolutionTransmembrane pH imaging distinguishes glycolytic and oxidative phenotypes in gliomas
Coman D, Mishra S, Kurdi S, Santana J, Hyder F. Transmembrane pH imaging distinguishes glycolytic and oxidative phenotypes in gliomas. Proceedings Of The International Society For Magnetic Resonance In Medicine ... Scientific Meeting And Exhibition. 2025 DOI: 10.58530/2025/3064.Peer-Reviewed Original ResearchCommentary on: Comparative Analysis of Systemic Immune Responses and Metastatic Risks in Tumor Ablation: An Animal Study of Radiofrequency Ablation and Irreversible Electroporation with Immune Modulation
Gois Santana J, Chapiro J. Commentary on: Comparative Analysis of Systemic Immune Responses and Metastatic Risks in Tumor Ablation: An Animal Study of Radiofrequency Ablation and Irreversible Electroporation with Immune Modulation. CardioVascular And Interventional Radiology 2025, 48: 536-537. PMID: 40097621, DOI: 10.1007/s00270-025-04009-7.Commentaries, Editorials and LettersWomen’s Leadership Development at the Yale School of Medicine: Preliminary Evaluation of an Innovative Program
David D, Arora I, Hussein A, Santana J, Crusto C, Latimore D. Women’s Leadership Development at the Yale School of Medicine: Preliminary Evaluation of an Innovative Program. Women's Health Reports 2025, 6: whr.2024.0188. PMID: 40308350, PMCID: PMC12040562, DOI: 10.1089/whr.2024.0188.Peer-Reviewed Original ResearchYale School of Medicineacademic medicineleadership development programsSchool of Medicineacquisition of leadership skillsYale Schoolfaculty members' confidenceleadership development initiativesenhancing leadership capacityleadership pathwaysmembers' confidencemedical schoolsretrospective survey dataleadership skillsinnovative programsleadership developmentorganizational changeincreased confidenceleadership efficacyleadership visionleadership capacityleadership potentialwomendevelopment programswomen leaders
2024
Molecular MRI of T-cell immune response to cryoablation in immunologically hot vs. cold hepatocellular carcinoma
Santana J, Shewarega A, Nam D, Duncan J, Madoff D, Hyder F, Coman D, Chapiro J. Molecular MRI of T-cell immune response to cryoablation in immunologically hot vs. cold hepatocellular carcinoma. JHEP Reports 2024, 7: 101294. PMID: 40028344, PMCID: PMC11870164, DOI: 10.1016/j.jhepr.2024.101294.Peer-Reviewed Original ResearchT cell infiltrationhepatocellular carcinomaradiological-pathological correlationImaging Mass Cytometryimmune responseT1-weighted MRItumor-infiltrating CD8+ T lymphocytesanti-tumor immune responseCD8+ T lymphocytesincreased T lymphocyte infiltrationimaging biomarkersnon-immunogenic tumorssystemic lymph nodesT lymphocyte infiltrationmurine tumor modelsimmune cell typeslocal tumor therapyprimary liver cancernon-invasive imaging biomarkerTesla MRI scannerinduce liver cirrhosisimmunogenic tumorslocoregional therapysystemic immunotherapyHCC lesionsEffect of Incomplete Cryoablation and Matrix Metalloproteinase Inhibition on Intratumoral CD8+ T-Cell Infiltration in Murine Hepatocellular Carcinoma.
Shewarega A, Santana J, Nam D, Berz A, Tefera J, Kahl V, Mishra S, Coman D, Duncan J, Roberts S, Wetter A, Madoff D, Chapiro J. Effect of Incomplete Cryoablation and Matrix Metalloproteinase Inhibition on Intratumoral CD8+ T-Cell Infiltration in Murine Hepatocellular Carcinoma. Radiology 2024, 310: e232365. PMID: 38349244, PMCID: PMC10902598, DOI: 10.1148/radiol.232365.Peer-Reviewed Original ResearchConceptsT cell infiltrationCD8<sup>+</sup> T cellsmatrix metalloproteinase inhibitionT cellshepatocellular carcinomamatrix metalloproteinase inhibitorsmatrix metalloproteinasesresidual tumorCXCR3<sup>+</sup> CD8<sup>+</sup> T cellscytotoxic CD8<sup>+</sup> T cell infiltrationintratumoral CD8+ T cell infiltrationCD8+ T cell infiltrationCD8<sup>+</sup> T cell infiltrationmouse model of hepatocellular carcinomaearly-stage hepatocellular carcinomaimage-guided tumor ablationUnpaired Student's <i>t</i> testmodel of hepatocellular carcinomafirst-line therapymurine hepatocellular carcinomaT cell subsetstumor-associated macrophagesmurine HCC modellocal immune responsefemale BALB/c miceTransmembrane pH gradient imaging in rodent glioma models
Mishra S, Santana J, Mihailovic J, Hyder F, Coman D. Transmembrane pH gradient imaging in rodent glioma models. NMR In Biomedicine 2024, 37: e5102-e5102. PMID: 38263680, PMCID: PMC10987279, DOI: 10.1002/nbm.5102.Peer-Reviewed Original Researchnormal tissuesrodent glioma modelsGL261 gliomasU87 gliomastumor microenvironmentpotential therapeutic targetglioma modeltumor survivalextracellular acidosistumormetabolic reprogrammingregulate drug deliveryintracellular pHrat brainextracellular pHtherapeutic targetgliomamouse braindrug deliveryintracellular milieutransmembrane pH gradientbrainsubmillimeter resolutiontissuecells
2023
Hepatic Hypertrophy in Normal and Cirrhotic Livers Following Portal Vein Embolization: Comparative Assessment of 2 Different Embolic Regimens in a Large Animal Model
Kuhn T, Kahl V, Wang Y, Berz A, Shewarega A, Santana J, Antoch G, Chapiro J, Schlachter T, Madoff D. Hepatic Hypertrophy in Normal and Cirrhotic Livers Following Portal Vein Embolization: Comparative Assessment of 2 Different Embolic Regimens in a Large Animal Model. Journal Of Vascular And Interventional Radiology 2023, 34: 2162-2172.e2. PMID: 37634850, DOI: 10.1016/j.jvir.2023.08.024.Peer-Reviewed Original ResearchConceptsportal vein embolizationfuture liver remnantvein embolizationliver remnantcirrhotic liverstandardized future liver remnantnon-cirrhotic groupimmune cell infiltrationnon-cirrhotic liverN-butyl cyanoacrylatet-testfemale Yorkshire pigslarge animal modellarge animal studiesStudent's t-testcirrhotic groupembolized lobebaseline percentagehepatic hypertrophycell infiltrationbaseline CTKi-67preclinical studiesInstitutional Animal CareFLR increasePredicting tumor recurrence on baseline MR imaging in patients with early-stage hepatocellular carcinoma using deep machine learning
Kucukkaya A, Zeevi T, Chai N, Raju R, Haider S, Elbanan M, Petukhova-Greenstein A, Lin M, Onofrey J, Nowak M, Cooper K, Thomas E, Santana J, Gebauer B, Mulligan D, Staib L, Batra R, Chapiro J. Predicting tumor recurrence on baseline MR imaging in patients with early-stage hepatocellular carcinoma using deep machine learning. Scientific Reports 2023, 13: 7579. PMID: 37165035, PMCID: PMC10172370, DOI: 10.1038/s41598-023-34439-7.Peer-Reviewed Original Research