Adjunct Faculty
Adjunct faculty typically have an academic or research appointment at another institution and contribute or collaborate with one or more School of Medicine faculty members or programs.
Adjunct rank detailsJens Bruning, MD
About
Research
Publications
2026
Mitochondrial fission factor regulates mitochondrial Ca2+ homeostasis and neuronal activity in AgRP neurons
Del Río-Martín A, Yeghiazaryan G, de Oliveira Beleza R, Henschke S, Solheim M, Mirabella P, Sotelo-Hitschfeld T, Bauder C, Jiang H, Chen W, Klemm P, Steuernagel L, de Solís A, Hammerschmidt P, Fenselau H, Wunderlich F, Kloppenburg P, Brüning J. Mitochondrial fission factor regulates mitochondrial Ca2+ homeostasis and neuronal activity in AgRP neurons. Neuron 2026 PMID: 42068979, DOI: 10.1016/j.neuron.2026.03.038.Peer-Reviewed Original ResearchHypoMap3D: a reference spatio-cellular atlas of the mouse hypothalamus for studying neuroendocrine biology and disorders
Feldmann M, von R, Bruning J, Yeo G, Steuernagel L, Lam B. HypoMap3D: a reference spatio-cellular atlas of the mouse hypothalamus for studying neuroendocrine biology and disorders. Endocrine Abstracts 2026 DOI: 10.1530/endoabs.117.op1.3.Peer-Reviewed Original Research
2025
Author Correction: Projectome-based characterization of hypothalamic peptidergic neurons in male mice
Jiao Z, Gao T, Wang X, Wang A, Ma Y, Feng L, Gao L, Gou L, Zhang W, Biglari N, Boxer E, Steuernagel L, Ding X, Yu Z, Li M, Gao M, Hao M, Zhou H, Cao X, Li S, Jiang T, Qi J, Jia X, Feng Z, Ren B, Chen Y, Shi X, Wang D, Wang X, Han L, Liang Y, Qian L, Jin C, Huang J, Deng W, Wang C, Li E, Hu Y, Tao Z, Li H, Yu X, Xu M, Chang H, Zhang Y, Xu H, Yan J, Li A, Luo Q, Stoop R, Sternson S, Brüning J, Anderson D, Poo M, Sun Y, Xu S, Gong H, Sun Y, Xu X. Author Correction: Projectome-based characterization of hypothalamic peptidergic neurons in male mice. Nature Neuroscience 2025, 29: 246-246. PMID: 41331143, DOI: 10.1038/s41593-025-02184-x.Commentaries, Editorials and Letters2-hydroxyglutarate mediates whitening of brown adipocytes coupled to nuclear softening upon mitochondrial dysfunction
Kaul H, Isermann L, Senft K, Popovic M, Georgomanolis T, Baumann L, Sivanesan P, Pouikli A, Nolte H, Lucic B, Hildebrandt X, Seidel K, Gnad T, Gaedke F, Göbel U, Peters F, Cherevatenko M, Park J, Schauss A, Peltzer N, Brüning J, Kornfeld J, Pfeifer A, Langer T, Lusic M, Wickström S, Frezza C, Trifunovic A. 2-hydroxyglutarate mediates whitening of brown adipocytes coupled to nuclear softening upon mitochondrial dysfunction. Nature Metabolism 2025, 7: 1593-1613. PMID: 40750944, PMCID: PMC12373511, DOI: 10.1038/s42255-025-01332-8.Peer-Reviewed Original ResearchB cell-derived nociceptin/orphanin FQ contributes to impaired glucose tolerance and insulin resistance in obesity
Puente-Ruiz S, Ide L, Schuller J, Ben-Kraiem A, Hoffmann A, Ghosh A, Noé F, Wolfrum C, Krause K, Gericke M, Klöting N, Brüning J, Wunderlich F, Blüher M, Jais A. B cell-derived nociceptin/orphanin FQ contributes to impaired glucose tolerance and insulin resistance in obesity. IScience 2025, 28: 112819. PMID: 40662198, PMCID: PMC12256348, DOI: 10.1016/j.isci.2025.112819.Peer-Reviewed Original ResearchHypothalamic PNOC/NPY neurons constitute mediators of leptin-controlled energy homeostasis
Solheim M, Stroganov S, Chen W, Subagia P, Bauder C, Wnuk-Lipinski D, Del Río-Martín A, Sotelo-Hitschfeld T, Beddows C, Klemm P, Dodd G, Lundh S, Secher A, Wunderlich F, Steuernagel L, Brüning J. Hypothalamic PNOC/NPY neurons constitute mediators of leptin-controlled energy homeostasis. Cell 2025, 188: 3550-3566.e22. PMID: 40273910, DOI: 10.1016/j.cell.2025.04.001.Peer-Reviewed Original ResearchMyeloperoxidase impacts vascular function by altering perivascular adipocytes’ secretome and phenotype in obesity
Hof A, Landerer M, Peitsmeyer P, Herzog R, Alber J, Ahdab M, Nettersheim F, Mehrkens D, Geißen S, Braumann S, Guthoff H, von Stein P, Nemade H, Picard F, Braun R, Hoyer F, Brüning J, Pfeifer A, Hildebrand S, Winkels H, Baldus S, Adam M, Schäkel J, Mollenhauer M. Myeloperoxidase impacts vascular function by altering perivascular adipocytes’ secretome and phenotype in obesity. Cell Reports Medicine 2025, 6: 102087. PMID: 40252642, PMCID: PMC12147848, DOI: 10.1016/j.xcrm.2025.102087.Peer-Reviewed Original ResearchReduced Notch signaling in hypothalamic endothelial cells mediates obesity-induced alterations in glucose uptake and insulin signaling
Zhu Y, Mehlkop O, Backes H, Cremer A, Porniece M, Klemm P, Steuernagel L, Chen W, Johnen R, Wunderlich F, Jais A, Brüning J. Reduced Notch signaling in hypothalamic endothelial cells mediates obesity-induced alterations in glucose uptake and insulin signaling. Cell Reports 2025, 44: 115522. PMID: 40186867, DOI: 10.1016/j.celrep.2025.115522.Peer-Reviewed Original ResearchProjectome-based characterization of hypothalamic peptidergic neurons in male mice
Jiao Z, Gao T, Wang X, Wang A, Ma Y, Feng L, Gao L, Gou L, Zhang W, Biglari N, Boxer E, Steuernagel L, Ding X, Yu Z, Li M, Gao M, Hao M, Zhou H, Cao X, Li S, Jiang T, Qi J, Jia X, Feng Z, Ren B, Chen Y, Shi X, Wang D, Wang X, Han L, Liang Y, Qian L, Jin C, Huang J, Deng W, Wang C, Li E, Hu Y, Tao Z, Li H, Yu X, Xu M, Chang H, Zhang Y, Xu H, Yan J, Li A, Luo Q, Stoop R, Sternson S, Brüning J, Anderson D, Poo M, Sun Y, Xu S, Gong H, Sun Y, Xu X. Projectome-based characterization of hypothalamic peptidergic neurons in male mice. Nature Neuroscience 2025, 28: 1073-1088. PMID: 40140607, DOI: 10.1038/s41593-025-01919-0.Peer-Reviewed Original ResearchAuthor Correction: A comprehensive spatio-cellular map of the human hypothalamus
Tadross J, Steuernagel L, Dowsett G, Kentistou K, Lundh S, Porniece M, Klemm P, Rainbow K, Hvid H, Kania K, Polex-Wolf J, Knudsen L, Pyke C, Perry J, Lam B, Brüning J, Yeo G. Author Correction: A comprehensive spatio-cellular map of the human hypothalamus. Nature 2025, 639: e17-e17. PMID: 40000749, PMCID: PMC11903310, DOI: 10.1038/s41586-025-08826-1.Commentaries, Editorials and Letters