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Janna D Helfrich, MD

she/her/hers
Assistant Professor
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Contact Info

Yale School of Medicine

333 Cedar St, Dept of Anesthesiology

New Haven, CT 06510

United States

About

Titles

Assistant Professor

Appointments

Other Departments & Organizations

Education & Training

Resident
University Medical Center Tuebingen (2022)
Postdoctoral Fellow
University of California at Berkeley (2019)
Resident
University Medical Center Hamburg-Eppendorf (2016)
Fellow, Intensive Care Medicine
University Medical Center Hamburg Eppendorf (2016)
Fellow, Prehospital Emergency Care
University Medical Center Hamburg-Eppendorf (2015)
PhD
Charite University Medical Center, Physiology (2015)
MD
Charite University Medical Center Berlin, Medicine (2012)

Research

Overview

Anesthesia is applied neuroscience, and neuroscience uses anesthesia as a powerful experimental probe to understand how brain networks give rise to consciousness—and how disrupting those networks alters cognition and behavior.

The Helfrich Lab investigates the neurophysiology of unconscious states and their consequences for human cognition, using primarily scalp electroencephalography (EEG) to characterize shared and state-specific neural mechanisms across anesthesia, sleep, and disorders of consciousness.

Our work asks whether anesthesia can be re-engineered to more closely resemble sleep rather than coma, thereby reducing postoperative cognitive side effects while potentially harnessing sleep’s restorative functions, and whether anesthetic perturbations can serve as diagnostic probes to predict recovery trajectories in patients with coma or other disorders of consciousness. The overarching goal of this research is to translate mechanistic insights into improved clinical care for all patients.

Medical Research Interests

Anesthesia; Consciousness; Electroencephalography; Neurosciences; Sleep

Research at a Glance

Yale Co-Authors

Frequent collaborators of Janna D Helfrich's published research.

Publications

2026

2025

2024

2023

Academic Achievements & Community Involvement

Honors

  • honor

    WAKWin Mentorship Award

  • honor

    Travel Grant

  • honor

    Travel Grant

  • honor

    Travel Grant

  • honor

    Travel Grant

Clinical Care

Overview

Janna D. Helfrich, MD, is an anesthesiologist who cares for adults before, during, and after surgery. She focuses on providing safe anesthesia care and supporting patients through all phases of their surgical experience.

Dr. Helfrich cares for patients with a wide range of medical conditions who need anesthesia for surgery or procedures. She monitors vital signs such as blood pressure, heart rate, and breathing, and adjusts anesthesia medications to keep patients comfortable and safe. She also has training in intensive care and prehospital emergency care, which helps her manage patients who are critically ill or at higher risk during surgery.

As an assistant professor at Yale School of Medicine, Dr. Helfrich studies how anesthesia affects the brain and consciousness. Her research uses brainwave recordings, called EEG, to compare anesthesia with natural sleep and with conditions such as coma. She aims to better understand how changes in brain activity under anesthesia may affect thinking and memory after surgery, and how this knowledge can be used to improve patient care.

Dr. Helfrich earned her medical degree and a medical doctorate from Charite University Medical Center Berlin. She completed residency training in anesthesiology at University Medical Center Tuebingen and University Medical Center Hamburg-Eppendorf, all in Germany. She also pursued fellowship training in prehospital emergency care and intensive care medicine at University Medical Center Hamburg-Eppendorf, and a postdoctoral fellowship in neuroscience at the University of California at Berkeley.

Clinical Specialties

Anesthesiology

Board Certifications

  • Anesthesiology

    Certification Organization
    German Board Certificate
    Original Certification Date
    2022

Get In Touch

Contacts

Mailing Address

Yale School of Medicine

333 Cedar St, Dept of Anesthesiology

New Haven, CT 06510

United States

Locations

  • Brady Memorial Laboratory

    Lab

    310 Cedar Street, Fl 4, Rm 419

    New Haven, CT 06510

  • Patient Care Locations

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