James B. Yu, MD, MHS, FASTRO
Cards
Appointments
Contact Info
Radiation Oncology
1 Medical Center Drive
Lebanon, NH 03766
United States
About
Titles
Assistant Professor Adjunct
Biography
James Yu, MD, MHS, is Professor of Radiation Oncology and Genitourinary Cancers Radiotherapy Lead at Dartmouth Hitchcock Medical Center in Lebanon, New Hampshire.
He is a former Professor of Radiation Oncology at the Yale School of Medicine, former Associate Chief Medical Officer of the Smilow Cancer Hospital and Care Centers and Executive Vice Chair of Columbia University Irving Medical Center Department of Radiation Oncology.
In his academic work, Dr. Yu conducts research on ways to use radiotherapy treatments to improve outcomes for cancer patients. “We need to push the field ever forward and not be satisfied with merely prolonging survival,” says Dr. Yu. “I think radiosurgery will play a role in this. As systemic therapies improve and our ability to control microscopically disseminated disease improves, noninvasive ablative therapies will become ever more important.”
As a former Yale Center for Clinical Investigation scholar and founding member of the Cancer Outcomes, Public Policy, and Effectiveness Research (COPPER) Center at Yale, Dr. Yu’s research centers on the comparative effectiveness of new radiation technologies and how these new technologies are adopted nationally.
Dr. Yu is the Editor-in Chief of JNCI Cancer Spectrum, Deputy Editor-In-Chief of the journal Practical Radiation Oncology and is on the editorial boards of the Journal of Clinical Oncology - Clinical Cancer Informatics, JNCI, Journal of Surgical Oncology, and Oncology (Williston Park), and former editorial board member of the Journal of Clinical Oncology.
He has published over 350 original manuscripts and co-edited the textbook Pocket Radiation Oncology and Principles of Clinical Cancer Research. He is the radiation oncology co-chair for the Southwest Oncology Group Genitourinary Cancers Committee, and a nationally recognized expert in patient reported outcomes.
Appointments
Medical Oncology and Hematology
Assistant Professor AdjunctPrimary
Other Departments & Organizations
- Brain Tumor Center
- COPPER Center
- Gamma Knife Center
- Internal Medicine
- Medical Oncology
- Medical Oncology and Hematology
- Pituitary Program
- Prostate & Urologic Cancers Program
- Radiation Oncology
- Yale Cancer Center
- Yale Ventures
- Yale-BI Biomedical Data Science Fellowship
Education & Training
- MHS
- Yale University, Masters of Health Science (2014)
- Resident
- Yale New Haven Hospital (2009)
- Chief Resident
- Yale School of Medicine (2009)
- Intern
- California Pacific Medical Center, San Francisco, CA (2005)
- MD
- University of Michigan Medical School (2004)
- BS
- Yale University (1999)
Research
Overview
Medical Research Interests
ORCID
0000-0002-3119-3226- View Lab Website
Cancer Outcomes, Public Policy, and Effectiveness Research (COPPER) Center at Yale
Research at a Glance
Yale Co-Authors
Publications Timeline
Research Interests
Henry S. Park, MD, MPH
Cary P Gross, MD
Veronica Chiang, MD, FAANS
Sanjay Aneja, MD
Kenneth B. Roberts, MD
Lynn D. Wilson, MD, MPH, FASTRO
Breast Neoplasms
Radiotherapy, Intensity-Modulated
Head and Neck Neoplasms
Publications
2025
Power as an explanation for cancer disparities: a commentary on Krieger et al.
Hudson M, Yu J. Power as an explanation for cancer disparities: a commentary on Krieger et al. JNCI Cancer Spectrum 2025, 9: pkaf072. PMID: 40912682, PMCID: PMC12413224, DOI: 10.1093/jncics/pkaf072.Peer-Reviewed Original ResearchEvaluation of the ESMO-Magnitude of Clinical Benefit Scale version 1.1 for the treatment of extracranial oligometastatic non-small cell lung cancer with radiosurgery
Yu J, Corn B, Qureshi S, Jairam V, Yu L, Pendyala P, Riaz A, Ennis R, Sapir E. Evaluation of the ESMO-Magnitude of Clinical Benefit Scale version 1.1 for the treatment of extracranial oligometastatic non-small cell lung cancer with radiosurgery. Practical Radiation Oncology 2025 PMID: 40865796, DOI: 10.1016/j.prro.2025.07.008.Peer-Reviewed Original ResearchConceptsNon-small cell lung cancerOligometastatic non-small cell lung cancerCell lung cancerESMO-MCBS v1.1ESMO-MCBSRadiation therapyClinical benefitEpidermal growth factor receptor-mutant non-small cell lung cancerLung cancerAmerican Society for Radiation Oncology (ASTROStereotactic body radiation therapyClinical research studiesStandard-of-care chemotherapyMagnitude of Clinical Benefit ScaleProgression-free survivalEpidermal growth factor receptorSingle-arm studyGrowth factor receptorEuropean SocietyQuality-of-life improvementAssociated with substantial improvementsOligometastatic diseaseStereotactic radiotherapyLocal therapyTargeted therapy30 year trends in racial disparities for early stage lung cancer treatment.
Lynch O, Lee D, Soulos P, Yu J, Herrin J, Gross C. 30 year trends in racial disparities for early stage lung cancer treatment. Journal Of Clinical Oncology 2025, 43: 1599-1599. DOI: 10.1200/jco.2025.43.16_suppl.1599.Peer-Reviewed Original ResearchConceptsReceipt of curative therapyReceipt of curative treatmentCurative therapyCurative treatmentLung cancer treatmentWhite patientsBlack patientsReceipt of treatmentRacial disparitiesBlack-white differencesStage I-II NSCLCEarly stage lung cancerCancer treatmentStage lung cancerYears prior to diagnosisMedicare beneficiariesMonths of diagnosisRetrospective cohort studyMultivariate logistic regressionAssessed temporal trendsNon-LatinxProbability of treatmentPredictive probability of treatmentSEER-MedicareLung cancerPractical Considerations for the Treatment of Primary Renal Cell Carcinoma With SABR
Yu J, Grew D, Sculley E, Siva S, Hardcastle N, Tang C, Yang J, Kim M, Lo S. Practical Considerations for the Treatment of Primary Renal Cell Carcinoma With SABR. Practical Radiation Oncology 2025 PMID: 40323243, DOI: 10.1016/j.prro.2025.03.007.Peer-Reviewed Original ResearchAltmetricSalvage Radiosurgery After Brachytherapy for Locally Recurrent Prostate Cancer With Real-Time Adaptive Motion Management Using Previously Implanted Brachytherapy Seeds as Fiducial Markers
Yu J, Grew D, Singh C, Sculley E, Jones A, Munbodh R. Salvage Radiosurgery After Brachytherapy for Locally Recurrent Prostate Cancer With Real-Time Adaptive Motion Management Using Previously Implanted Brachytherapy Seeds as Fiducial Markers. Cureus 2025, 17: e81373. PMID: 40291214, PMCID: PMC12034341, DOI: 10.7759/cureus.81373.Peer-Reviewed Original ResearchConceptsPlanning target volumeGross tumor volumeImplanted brachytherapy seedsProstate-specific antigenStereotactic body radiation therapyLocally recurrent prostate cancerLow dose rateBrachytherapy seedsRecurrent prostate cancerProstate cancerProstate-specific membrane antigen positron emission tomographyLocal recurrence of prostate cancerDeclining prostate-specific antigenRecurrence of prostate cancerFiducial marker placementPatient tolerated therapyTarget volumeRobotic radiosurgeryFiducial markersDose ratePositron emission tomographyPSMA-PETSalvage radiosurgeryLocal recurrenceRadiation therapyMediators of Racial Inequities in Non‐Small Cell Lung Cancer Care
Hamid S, Lee D, Herrin J, Yu J, Pollack C, Dean L, Gaddy J, Oladele C, Feder S, Canavan M, Nunez-Smith M, Soulos P, Gross C. Mediators of Racial Inequities in Non‐Small Cell Lung Cancer Care. Cancer Medicine 2025, 14: e70757. PMID: 40052387, PMCID: PMC11886416, DOI: 10.1002/cam4.70757.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsNon-small cell lung cancer carePhase of careSocioeconomic statusNon-small cell lung cancerIndividual-level socioeconomic statusNeighborhood-level socioeconomic statusMedicare-Medicaid dual eligibilityWhite patientsHealth care accessLung cancer careNon-Hispanic blacksIndirect effects of mediatorsDiagnosis stageStage-appropriate treatmentTwo-year survivalCancer careCare accessEffects of raceOptimal careDual eligiblesCareStructural racismRacial inequalityBlack patientsInadequate evaluation
2024
Comparative Effectiveness of SBRT
Shen J, Sritharan D, Yu J, Aneja S. Comparative Effectiveness of SBRT. 2024, 455-467. DOI: 10.1007/978-3-031-67743-4_33.Peer-Reviewed Original ResearchAltmetricConceptsStereotactic body radiation therapyEffect of stereotactic body radiation therapyAlternative to other treatment modalitiesStereotactic body radiation therapy treatmentLong-term follow-up of patientsFollow-up of patientsLong-term follow-upTreatment of brainOligometastatic diseaseRadiation therapyTreatment of cancerRetrospective seriesTreatment modalitiesRenal cancerCost-effectiveness studiesDatabase analysisCancerTreatmentProstateTherapyInappropriate Denials for Radiation Therapy in Medicare Advantage Plans
Pasetsky J, Bhatt K, Kachnic L, Yu J, Horowitz D. Inappropriate Denials for Radiation Therapy in Medicare Advantage Plans. International Journal Of Radiation Oncology • Biology • Physics 2024, 121: 871-874. PMID: 39551102, DOI: 10.1016/j.ijrobp.2024.11.063.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsIntensity-modulated RTRadiation therapyStereotactic body radiation therapyHealth servicesMedicare Advantage plansMedicare-eligible patientsChi-square testRadiation oncologistsProstate cancerTreatment modalitiesBreast cancerCancer treatmentTherapyCancerRT servicesPolicy changesMedicaid Services websiteCoverage guidelinesDenial ratesMedical specialtiesCenters for Medicare & Medicaid Services websiteTreatmentDenialBrachytherapyProstateRadiation Therapy for the Treatment of Osteoarthritis
Yu J, Grew D, Spraker M, Beckta J, Shah C, Brower J. Radiation Therapy for the Treatment of Osteoarthritis. Practical Radiation Oncology 2024, 15: 19-24. PMID: 39503700, DOI: 10.1016/j.prro.2024.09.003.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsRadiation therapyAssessment of treatment responseTreatment of osteoarthritisMedically refractory diseaseNonsteroidal anti-inflammatory drugsNoninvasive treatment optionCause of painCyclooxygenase-2 inhibitorsIntra-articular corticosteroid therapyAnti-inflammatory drugsCorticosteroid therapyRefractory diseaseTreatment responseTreatment optionsClinical evidenceOlder patientsTherapyCyclooxygenase-2PatientsTraditional treatmentPhysical therapyPainTreatmentOsteoarthritisTechnical considerationsTestosterone Recovery and Associated Impact on Patient-Reported Health-Related Quality of Life (HRQoL) after Treatment with 6 Months of GnRH Agonist with or without Abiraterone Acetate plus Prednisone (AAP) and Apalutamide (Apa) in the FORMULA-509 Trial
Moningi S, Nguyen P, Rathkopf D, Zurita-Saavedra A, Spratt D, Dess R, Liauw S, Szmulewitz R, Einstein D, Bubley G, Yu J, An Y, Wong A, Feng F, Mckay R, Rose B, Shin K, Taplin M, Kollmeier M, Hoffman K. Testosterone Recovery and Associated Impact on Patient-Reported Health-Related Quality of Life (HRQoL) after Treatment with 6 Months of GnRH Agonist with or without Abiraterone Acetate plus Prednisone (AAP) and Apalutamide (Apa) in the FORMULA-509 Trial. International Journal Of Radiation Oncology • Biology • Physics 2024, 120: e563-e564. DOI: 10.1016/j.ijrobp.2024.07.1247.Peer-Reviewed Original ResearchConceptsMonths of GnRH agonistTestosterone recoveryGnRH agonistAssociated with lackClinically meaningful changeBaseline testosteroneAssociated with testosterone recoveryMedian Follow-UpEvaluated prior to treatmentTreatment groupsTrial randomized patientsHormonal functionPatient-reported health-related quality of lifeLog-rank testCompletion of treatmentMultivariate logistic regressionWilcoxon rank-sumPatient-reported HRQoL.Salvage radiationGleason scoreAbiraterone acetateHigher PSARecovery 1 yearRandomized patientsHealth-related quality of life
Academic Achievements & Community Involvement
Honors
honor Fellow
07/17/2023National AwardAmerican Society for Radiation OncologyDetailsUnited Stateshonor Cancer Prevention and Control Research Prize
12/31/2017Yale School of Medicine AwardYale Cancer CenterDetailsUnited Stateshonor Population Research Prize
11/22/2013Yale School of Medicine AwardYale Cancer CenterDetailsUnited Stateshonor Seattle Prostate Brachytherapy Fellow
01/01/2009National AwardAmerican Brachytherapy SocietyDetailsUnited Stateshonor Roentgen Resident Research Award
01/01/2008National AwardRSNADetailsUnited States
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Radiation Oncology
1 Medical Center Drive
Lebanon, NH 03766
United States