Voluntary Faculty
Voluntary faculty are typically clinicians or others who are employed outside of the School but make significant contributions to department programs at the medical center or at affiliate institutions.
Voluntary rank detailsJonathan Alexander, MD
Assistant Clinical ProfessorAbout
Research
Publications
2026
Pathophysiology Annual Report Card 2025
Alexander J. Pathophysiology Annual Report Card 2025. Pathophysiology 2026, 33: 17. PMID: 41718395, PMCID: PMC12921829, DOI: 10.3390/pathophysiology33010017.Peer-Reviewed Original ResearchAn Alternative Approach to Vaginal Expansion-Utilizing Estrogen Coated 3-D Printed Vaginal Expansion Sleeves
Gotberg A, Colvin J, Meyer H, Cline R, Solitro G, Alexander J, Sorrells D, Shah-Bruce M. An Alternative Approach to Vaginal Expansion-Utilizing Estrogen Coated 3-D Printed Vaginal Expansion Sleeves. North American Proceedings In Gynecology And Obstetrics - Supplemental 2026 DOI: 10.54053/001c.155207.Peer-Reviewed Original ResearchVaginal wallVaginal canalSprague Dawley ratsSigns of infectionVaginal lengthHistological analysisVaginal tissueAdjunctive therapyLubricant jellyMechanical dilatationModerate inflammationDawley ratsMayer-Rokitansky-Kuster-HauserNo sign of infectionMild to moderate inflammationTumor necrosis factor-aGLP-2IACUC-approved protocolLuer lock syringeHematoxylin and eosinAdjunctive estrogenResin capVaginal atresiaNo signGeneration of nitric oxide
2025
Clinical Phenotypes of Obstructive Sleep Apnea: A Decade of Evidence Toward Personalized Management
Rosales W, Vanka S, Singh H, Bhamrah P, Bhamrah M, Ghildiyal N, Liendo C, Asghar S, Alexander J, Chernyshev O. Clinical Phenotypes of Obstructive Sleep Apnea: A Decade of Evidence Toward Personalized Management. Pathophysiology 2025, 33: 2. PMID: 41562843, PMCID: PMC12821736, DOI: 10.3390/pathophysiology33010002.Peer-Reviewed Original ResearchObstructive sleep apneaApnea-hypopnea indexPositive airway pressureAdherence to positive airway pressurePhenotypes of obstructive sleep apneaCardiovascular riskObstructive sleep apnea phenotypeModerate-to-severe diseaseMinimally symptomatic patientsComorbid associationsDisturbed sleepPersonalized treatment strategiesSymptom burdenOSA phenotypesSleep apneaSymptom-based phenotypesSymptomatic patientsAirway pressureSymptomatic improvementES patientsRisk stratificationTreatment responseUpper airwayCardiovascular risk predictionTreatment strategiesCalcification in Vascular Smooth Muscle Cells Is Associated with Elevated GCLm and Impaired Contraction: Insights into Osteogenic Transdifferentiation and Therapeutic Approaches
Delgadillo L, Rashdan N, Hamilton H, Pattillo J, Yuan S, Eshaq R, Harris N, Alexander J, Pattillo C. Calcification in Vascular Smooth Muscle Cells Is Associated with Elevated GCLm and Impaired Contraction: Insights into Osteogenic Transdifferentiation and Therapeutic Approaches. Pathophysiology 2025, 32: 66. PMID: 41441180, PMCID: PMC12736360, DOI: 10.3390/pathophysiology32040066.Peer-Reviewed Original ResearchVascular smooth muscle cellsGCL modifier subunitSmooth muscle cellsVascular calcificationGlutamate-cysteine ligaseCoronary artery vascular smooth muscle cellsHuman coronary artery vascular smooth muscle cellsMuscle cellsArtery vascular smooth muscle cellsPredictor of cardiovascular morbidityMurine vascular smooth muscle cellsVascular smooth muscle cell calcificationKEGG pathway analysisLoss of contractile phenotypeRegulating vascular smooth muscle cellOxidative stressImpaired contractionCardiovascular morbidityTherapeutic approachesOsteogenic transdifferentiationGlutamate-cysteine ligase modifier subunitContractile phenotypeEnzyme glutamate-cysteine ligasePhosphate-rich mediumPhenotypic switchingNeurogranin-MYH9 interaction regulates cytoskeletal remodeling in cerebral vasculature
Akande A, Park J, Scott R, Alexander J, Nam H. Neurogranin-MYH9 interaction regulates cytoskeletal remodeling in cerebral vasculature. Fluids And Barriers Of The CNS 2025, 22: 94. PMID: 41029426, PMCID: PMC12487352, DOI: 10.1186/s12987-025-00709-x.Peer-Reviewed Original ResearchConceptsImmunoprecipitation-mass spectrometryCytoskeletal remodelingF-actinRegulator of cytoskeletal remodelingF-actin levelsAlzheimer's diseaseProximity ligation assayMYH9 knockdownAffinity pulldownUnrecognized functionLigation assayMYH9Brain microvascular endothelial cellsEndothelial cellsBarrier integrityKnockdownMicrovascular endothelial cellsMYH9 expressionAlzheimerNGRegulationBlood-brain barrier integrityInteractomeCellsRemodelingEnteric Elongation Induced by a Novel Sleeve Device in a Live Roux-en-Y Configuration
Colvin J, O’Quin C, Meyer H, Welch V, Solitro G, Alexander J, Sorrells D. Enteric Elongation Induced by a Novel Sleeve Device in a Live Roux-en-Y Configuration. Bioengineering 2025, 12: 771. PMID: 40722463, PMCID: PMC12292125, DOI: 10.3390/bioengineering12070771.Peer-Reviewed Original ResearchShort bowel syndromeRoux limb lengthRoux-en-YLong-term parenteral nutritionRoux-en-Y configurationDelayed gastric emptyingCurrent surgical optionsParenteral nutritionSurgical optionsIntestinal dilatationGastric emptyingBowel syndromeIntestinal lengtheningTissue remodelingRoux limbSleeve deviceWeeks post-deploymentBowelRatsLimb lengthWeeks4. Effect of GLP-2 Coated Vaginal Expansion Sleeves (VES) in a Rat Model
Colvin J, Cline R, Meyer H, Sorrells D, Alexander J, Shah-Bruce M. 4. Effect of GLP-2 Coated Vaginal Expansion Sleeves (VES) in a Rat Model. Journal Of Pediatric And Adolescent Gynecology 2025, 38: 221. DOI: 10.1016/j.jpag.2025.01.016.Peer-Reviewed Original ResearchVaginal lengthVaginal canalGLP-2Average vaginal lengthMild to moderate inflammationMinimally invasive alternativeGlucagon-like peptide 2Resin capVaginal atresiaRat vaginaDilation therapySurgical vaginoplastyLymphoid infiltratesCongenital absenceInvasive alternativeCanal lengthModerate inflammationProcedural interventionRat modelFemale reproductive tissuesCurrent treatmentNon-intestinal tissuesNonabsorbable suturesMuscular layerRats
2024
Validation of Therapeutic Agent Conjugation to Polyvinyl Alcohol-Coated Medical Devices.
Colvin J, Sorrells D, Alexander J. Validation of Therapeutic Agent Conjugation to Polyvinyl Alcohol-Coated Medical Devices. Journal Of Visualized Experiments 2024 PMID: 39671324, DOI: 10.3791/67358.Peer-Reviewed Original ResearchPathophysiology and Prevention of Manual-Ventilation-Induced Lung Injury (MVILI)
White L, Conrad S, Alexander J. Pathophysiology and Prevention of Manual-Ventilation-Induced Lung Injury (MVILI). Pathophysiology 2024, 31: 583-595. PMID: 39449524, PMCID: PMC11503381, DOI: 10.3390/pathophysiology31040042.Peer-Reviewed Original ResearchManual ventilationLung injuryManual hyperventilationOperator-dependent skillsShort-term ventilationMechanism of injuryManikin-based studyBag valve maskAmerican Heart AssociationEuropean Resuscitation CouncilHyperventilated patientsMechanical ventilationHemodynamic alterationsHealthcare providersHeart AssociationPatient populationResuscitation effortsGastric regurgitationResuscitation CouncilCardiopulmonary resuscitationVentilation parametersPatientsInjury processAcute barotraumaVentilationImpaired Peripheral Vascular Function Following Ischemic Stroke in Mice: Potential Insights into Blood Pressure Variations in the Post-Stroke Patient
Yilmaz G, Alexander J. Impaired Peripheral Vascular Function Following Ischemic Stroke in Mice: Potential Insights into Blood Pressure Variations in the Post-Stroke Patient. Pathophysiology 2024, 31: 488-501. PMID: 39311310, PMCID: PMC11417821, DOI: 10.3390/pathophysiology31030036.Peer-Reviewed Original ResearchIncreased blood pressure variabilityBlood pressure variabilityIschemic strokeAcetylcholine-induced endothelium-dependent vasodilationAssociated with poor clinical outcomesEndothelium-dependent vasodilator responsesPeripheral arteriesVascular smooth muscle toneResponse to SNPStroke animalsImpaired peripheral vascular functionPhenylephrine-induced vasoconstrictionEndothelium-dependent vasodilationPoor clinical outcomesSmooth muscle toneThoracic aortic segmentsDeterminants of blood pressurePressure variabilityPeripheral vascular functionPeripheral vascular responseWire myographyIsolated aortaVasoconstrictor responsesVasodilator responseRemote artery