Hong Lin, MD
About
Appointments
Education & Training
- MD
- New York University School of Medicine (2002)
Research
Publications
2024
Treadmill Exercise Enhances Post-Stroke Functional Recovery in Mice via the CX3CL1/CX3CR1 Signaling Pathway
Ge Y, Dou X, Chen P, Chen J, Dai M, Yao S, Lin Y. Treadmill Exercise Enhances Post-Stroke Functional Recovery in Mice via the CX3CL1/CX3CR1 Signaling Pathway. Molecular Neurobiology 2024, 1-13. PMID: 38886327, DOI: 10.1007/s12035-024-04287-1.Peer-Reviewed Original ResearchConceptsTreadmill exercisePost-strokeMorris water mazeTreadmill sessionsExercise mimeticsPost-stroke functional recoveryPost-ischemic strokePost-stroke recoveryTreadmillDentate gyrusRostral migratory streamEvaluate cognitive functionExerciseMiddle cerebral artery occlusionEnhanced neurogenesisCognitive functionModified neurological severity scoreSubventricular zoneSeverity scoreIschemic strokeSensorimotor functionControl groupFunctional recoveryExperimental groupIntraperitoneal injection of bromodeoxyuridineDiaphragm ultrasonography as a monitor in assessing antagonistic effect of sugammadex on rocuronium in patients with Child-Pugh grades A and B
Sun Y, Sun S, Chen R, Shen J, Chen X, Lin Y, Yao S. Diaphragm ultrasonography as a monitor in assessing antagonistic effect of sugammadex on rocuronium in patients with Child-Pugh grades A and B. Frontiers In Medicine 2024, 11: 1370021. PMID: 38686365, PMCID: PMC11057376, DOI: 10.3389/fmed.2024.1370021.Peer-Reviewed Original ResearchConceptsPreoperative Child-Pugh classificationEffects of sugammadexChild-Pugh classificationPost-anesthesia care unitThickening fractionDiaphragmatic ultrasonographyPost-surgeryChild-Pugh A groupLaparoscopic liver resection surgeryReversal effect of sugammadexChild-Pugh grade ACare unitNon-randomized controlled clinical trialChild-Pugh B groupBaseline diaphragm thicknessChild-Pugh gradeLiver resection surgeryDeep neuromuscular blockadeTrain-of-four ratioDiaphragm ultrasoundDiaphragm ultrasonographyDouble-blindNo significant differenceResection surgeryRocuronium-induced blockadeMaresins as novel anti-inflammatory actors and putative therapeutic targets in sepsis
Sun Y, Sun S, Chen P, Dai Y, Yang D, Lin Y, Yi L. Maresins as novel anti-inflammatory actors and putative therapeutic targets in sepsis. Pharmacological Research 2024, 202: 107113. PMID: 38387744, DOI: 10.1016/j.phrs.2024.107113.Peer-Reviewed Original ResearchAltmetricConceptsInflammatory response associated with sepsisIntensive care unit admissionDiagnosis of sepsisManagement of patientsHost response to infectionSuboptimal treatment strategyResponse to infectionFamily of lipid mediatorsUnit admissionUnfavorable outcomeTreatment strategiesSepsisClinical syndromeInflammatory processSepsis treatmentInflammation resolutionLipid mediatorsTherapeutic targetInaccurate diagnosisMaresinsDocosahexaenoic acidTermination of inflammatory processesT cell-mediated skin-brain axis: Bridging the gap between psoriasis and psychiatric comorbidities
Yang J, Zhang S, Wu Q, Chen P, Dai Y, Long J, Wu Y, Lin Y. T cell-mediated skin-brain axis: Bridging the gap between psoriasis and psychiatric comorbidities. Journal Of Autoimmunity 2024, 144: 103176. PMID: 38364575, DOI: 10.1016/j.jaut.2024.103176.Peer-Reviewed Original ResearchConceptsPsychiatric comorbiditiesMental disordersHypothalamic-pituitary-adrenal axisT cellsSuicidal ideationHPA axisPsychological disordersSympathetic nervous systemPsychiatric diseasesBlood-brain barrierDisordersMechanisms of T cellsChronic inflammatory skin conditionSkin diseasesEfficacy of treatmentPathogenesis of psoriasisInflammatory skin conditionProgression of psoriasisSecrete cytokinesIdeationPsoriasisComorbiditiesAnxietyDepressionNervous systemAbsence in CX3CR1 receptor signaling promotes post‐ischemic stroke cognitive function recovery through suppressed microglial pyroptosis in mice
Ge Y, Yang J, Chen J, Dai M, Dou X, Yao S, Yao C, Lin Y. Absence in CX3CR1 receptor signaling promotes post‐ischemic stroke cognitive function recovery through suppressed microglial pyroptosis in mice. CNS Neuroscience & Therapeutics 2024, 30: e14551. PMID: 38421089, PMCID: PMC10850801, DOI: 10.1111/cns.14551.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsMorris water mazeNovel object recognition testObject recognition testCX3CR1<sup>-/-</sup> micePost-stroke cognitive impairmentRecognition testCX3CR1 receptorCognitive behavioral performanceWater mazeBehavioral performanceCognitive dysfunctionDouble-positive cellsCognitive functionSource of morbidityCognitive impairmentPositron emission tomographyEnhanced neurogenesisCognitive function recoveryCX3CR1 knockoutExpression of GSDMDMicroglial pyroptosisChronic phaseInfarct volumeCX3CR1HippocampusStable-Isotope N‑Me Aziridination Enables Accurate Quantitative CC Isomeric Lipidomics
Feng G, Gao M, Chen H, Zhang Z, Chen J, Tong Y, Wu P, Fu R, Lin Y, Chen S. Stable-Isotope N‑Me Aziridination Enables Accurate Quantitative CC Isomeric Lipidomics. Analytical Chemistry 2024, 96: 2524-2533. PMID: 38308578, DOI: 10.1021/acs.analchem.3c04824.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsC-C bondsAccurate lipid quantificationAccurate relative quantificationOne-step introductionLipid isomersC bondSimultaneous qualificationLarge-scale resolutionMouse brain ischemiaStructural resolutionRelative quantificationUnsaturated lipidsLipid quantificationAccurate quantificationBrain ischemiaIsomersQuantificationActive groupEsterReactionPositive identificationPathological processesCholesterol estersLipidomics
2023
Strong opioids-induced cardiac, neurologic, and respiratory disorders: a real-world study from 2004 to 2023 based on FAERS
Dai M, Dou X, Chen M, Yang J, Long J, Lin Y. Strong opioids-induced cardiac, neurologic, and respiratory disorders: a real-world study from 2004 to 2023 based on FAERS. Naunyn-Schmiedeberg's Archives Of Pharmacology 2023, 397: 4105-4121. PMID: 38032491, DOI: 10.1007/s00210-023-02844-4.Peer-Reviewed Original ResearchCitationsConceptsAcute adverse drug reactionsEmpirical Bayesian geometric meanAdverse eventsSystem organ classReporting odds ratioProportional reporting ratioAdverse Event Reporting System databaseFDA Adverse Event Reporting System (FAERS) databaseSevere cancer painAdverse drug reactionsNervous system disordersReal-world studyUS FDA Adverse Event Reporting System (FAERS) databaseReporting System databasePostoperative analgesiaCancer painRespiratory depressionChronic painToxic leukoencephalopathyGeneral anesthesiaMediastinal diseaseDrug reactionsMediastinal disordersOdds ratioRespiratory disordersMaresin1 prevents sepsis-induced acute liver injury by suppressing NF-κB/Stat3/MAPK pathways, mitigating inflammation
Sun S, Wang L, Wang J, Chen R, Pei S, Yao S, Lin Y, Yao C, Xia H. Maresin1 prevents sepsis-induced acute liver injury by suppressing NF-κB/Stat3/MAPK pathways, mitigating inflammation. Heliyon 2023, 9: e21883. PMID: 38027581, PMCID: PMC10665730, DOI: 10.1016/j.heliyon.2023.e21883.Peer-Reviewed Original ResearchCitationsConceptsSepsis-induced acute liver injuryAcute liver injuryAnti-inflammatory effectsLiver injuryNeutrophil infiltrationBacterial loadSurvival rateDocosahexaenoic acidNormal saline 1Peritoneal lavage fluidPro-inflammatory moleculesTreatment of sepsisUncontrolled inflammatory responseAnti-inflammatory moleculesSepsis-induced injuryEffects of MaR1Body weight changesSepsis-related diseasesDose-dependent mannerSaline 1Septic miceCecal ligationLavage fluidLiver functionAcute inflammationNeuromuscular Blocking Agents and Cancer: A Narrative Review
Chen R, Sun Y, Li Y, Dou X, Dai M, Sun S, Lin Y. Neuromuscular Blocking Agents and Cancer: A Narrative Review. Journal Of Clinical Pharmacy And Therapeutics 2023, 2023: 1-7. DOI: 10.1155/2023/5607134.Peer-Reviewed Original ResearchCitationsConceptsNeuromuscular blocking agentsCancer surgeryBlocking agentCancer cellsGastric cancer surgeryCell lung cancerFurther clinical studiesWeb of ScienceCancer resectionGeneral anesthesiaCancer cell behaviorCochrane LibraryLung cancerBreast cancerClinical studiesGastric cancerSurgeryNarrative reviewCancerAvailable evidenceClinical applicationFurther studiesAnesthesiaCurrent findingsCells
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