Henrique Novaes Morgan, MSc
Postgraduate AssociateAbout
Research
Publications
2026
Western diet-induced MASH in PWK/PhJ mice identifies disruptions in amino acid and sphingolipid metabolism contributing to cardiac dysfunction
Rodríguez-López S, Pérez-Rodríguez M, Badreddine A, Gaspar R, Novaes Morgan H, Sakuma I, von Alvensleben G, Alonso-Calleja A, Everts S, Suter N, Benegiamo G, Goepfert C, de Brot S, Villalba J, Shulman G, Schoonjans K, Auwerx J. Western diet-induced MASH in PWK/PhJ mice identifies disruptions in amino acid and sphingolipid metabolism contributing to cardiac dysfunction. Nature Communications 2026 PMID: 42156763, DOI: 10.1038/s41467-026-73449-7.Peer-Reviewed Original Research
2025
Control of hepatic gluconeogenesis in mice fed a high protein diet: a transcriptional shift from CREB to FoxO1
Camargo Neto J, Morgan H, Moro M, Assis A, Ruiz L, Schavinski A, Lautherbach N, Navegantes L, Kettelhut I. Control of hepatic gluconeogenesis in mice fed a high protein diet: a transcriptional shift from CREB to FoxO1. AJP Endocrinology And Metabolism 2025, 329: e810-e824. PMID: 41134648, DOI: 10.1152/ajpendo.00242.2025.Peer-Reviewed Original ResearchAnimalsBlood GlucoseCorticosteroneCyclic AMP Response Element-Binding ProteinDietary ProteinsForkhead Box Protein O1GluconeogenesisHepatocyte Nuclear Factor 4InsulinLiverMaleMiceMice, Inbred C57BLPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaPhosphorylationSignal TransductionTranscription, GeneticShort-term sustained hypoxia distinctly affects subpopulations of carotid body glomus cells from rats
Spiller P, Morgan H, Navegantes L, Machado B, da Silva M, Moraes D. Short-term sustained hypoxia distinctly affects subpopulations of carotid body glomus cells from rats. American Journal Of Physiology - Cell Physiology 2025, 328: c1346-c1365. PMID: 40094217, DOI: 10.1152/ajpcell.00967.2024.Peer-Reviewed Original ResearchHepatic Estrogen Receptor Alpha Overexpression Protects Against Hepatic Insulin Resistance and MASLD
Alves E, Santos J, Cruz A, Camargo F, Talarico C, Santos A, Silva C, Morgan H, Matos S, Araujo L, Camporez J. Hepatic Estrogen Receptor Alpha Overexpression Protects Against Hepatic Insulin Resistance and MASLD. Pathophysiology 2025, 32: 1. PMID: 39846638, PMCID: PMC11755535, DOI: 10.3390/pathophysiology32010001.Peer-Reviewed Original Research
2024
Hepatic noradrenergic innervation acts via CREB/CRTC2 to activate gluconeogenesis during cold
Morgan H, Delfino H, Schavinski A, Malone S, Charoy C, Reis N, Assis A, Lautherbach N, Silveira W, Heck L, Guton D, Domingos A, Kettelhut I, Montminy M, Navegantes L. Hepatic noradrenergic innervation acts via CREB/CRTC2 to activate gluconeogenesis during cold. Metabolism 2024, 157: 155940. PMID: 38878857, DOI: 10.1016/j.metabol.2024.155940.Peer-Reviewed Original ResearchCentral angiotensin-(1–7) attenuates hypoglycemia in sepsis-like conditions via reducing systemic and hepatic inflammation
Cardoso Santos G, Alves de Jesus A, Passaglia P, Novaes Morgan H, Carvalho Navegantes L, Leico Kagohara Elias L, Cárnio E. Central angiotensin-(1–7) attenuates hypoglycemia in sepsis-like conditions via reducing systemic and hepatic inflammation. Cytokine 2024, 179: 156637. PMID: 38723454, DOI: 10.1016/j.cyto.2024.156637.Peer-Reviewed Original ResearchMaternal Vitamin D Deficiency Impairs the Development of β Cells in Offspring Rats in a Sex-Dependent Manner
Schavinski A, Reis N, Morgan H, Assis A, Moro M, Valentim R, Seni-Silva A, Ramos E, Kettelhut I, Navegantes L. Maternal Vitamin D Deficiency Impairs the Development of β Cells in Offspring Rats in a Sex-Dependent Manner. International Journal Of Molecular Sciences 2024, 25: 4136. PMID: 38673723, PMCID: PMC11050228, DOI: 10.3390/ijms25084136.Peer-Reviewed Original Research
2022
Glucocorticoids decrease thermogenic capacity and increase triacylglycerol synthesis by glycerokinase activation in the brown adipose tissue of rats
Assis A, Silva K, Lautherbach N, Morgan H, Garófalo M, Zanon N, Navegantes L, Chaves V, do Carmo Kettelhut I. Glucocorticoids decrease thermogenic capacity and increase triacylglycerol synthesis by glycerokinase activation in the brown adipose tissue of rats. Lipids 2022, 57: 313-325. PMID: 36098349, DOI: 10.1002/lipd.12358.Peer-Reviewed Original ResearchMaternal vitamin D deficiency affects the morphology and function of glycolytic muscle in adult offspring rats
Reis N, Assis A, Lautherbach N, Gonçalves D, Silveira W, Morgan H, Valentim R, Almeida L, Heck L, Zanon N, Koike T, Santos A, Miyabara E, Kettelhut I, Navegantes L. Maternal vitamin D deficiency affects the morphology and function of glycolytic muscle in adult offspring rats. Journal Of Cachexia Sarcopenia And Muscle 2022, 13: 2175-2187. PMID: 35582969, PMCID: PMC9398225, DOI: 10.1002/jcsm.12986.Peer-Reviewed Original Research
2021
Calcitonin gene-related peptide exerts inhibitory effects on autophagy in the heart of mice
Schavinski A, Machado J, Morgan H, Lautherbach N, Paula-Gomes S, Kettelhut I, Navegantes L. Calcitonin gene-related peptide exerts inhibitory effects on autophagy in the heart of mice. Peptides 2021, 146: 170677. PMID: 34695513, DOI: 10.1016/j.peptides.2021.170677.Peer-Reviewed Original Research
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