George Aghajanian, MD
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Professor Emeritus of Psychiatry
Education & Training
- MD
- Yale University (1958)
- Resident
- Yale University
- Fellow
- Yale University
Research
Overview
Medical Subject Headings (MeSH)
Hallucinogens; Neuropharmacology; Neurophysiology; Psychiatry
Research at a Glance
Publications Timeline
A big-picture view of George Aghajanian's research output by year.
2Publications
325Citations
Publications
2009
Modeling “psychosis” in vitro by inducing disordered neuronal network activity in cortical brain slices
Aghajanian GK. Modeling “psychosis” in vitro by inducing disordered neuronal network activity in cortical brain slices. Psychopharmacology 2009, 206: 575-585. PMID: 19241062, PMCID: PMC2755104, DOI: 10.1007/s00213-009-1484-9.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsAberrant network activityBrain slicesReceptor agonistPyramidal cellsLayer V pyramidal cellsRecent phase II clinical trialPhase II clinical trialGABAA receptor antagonismStandard antipsychotic drugsMGlu2/3 receptor agonistGlutamatergic pyramidal cellsNetwork activityCortical brain slicesDopamine receptor agonistsTreatment of schizophreniaUsual side effectsPrefrontal brain slicesNeuronal network activityInterneuron deficitsGABA interneuronsClinical efficacyLysergic acid diethylamideMetabotropic receptorsReceptor antagonismClinical endpoints
2008
Stress blunts serotonin- and hypocretin-evoked EPSCs in prefrontal cortex: Role of corticosterone-mediated apical dendritic atrophy
Liu RJ, Aghajanian GK. Stress blunts serotonin- and hypocretin-evoked EPSCs in prefrontal cortex: Role of corticosterone-mediated apical dendritic atrophy. Proceedings Of The National Academy Of Sciences Of The United States Of America 2008, 105: 359-364. PMID: 18172209, PMCID: PMC2224217, DOI: 10.1073/pnas.0706679105.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsExcitatory postsynaptic currentsLayer V pyramidal neuronsMedial prefrontal cortexApical dendritic atrophyDendritic atrophyPyramidal neuronsRestraint stressPrefrontal cortexGlucocorticoid receptor antagonist RU486Apical dendritic fieldReceptor antagonist RU486Mild restraint stressWhole-cell recordingsMPFC slicesChronic treatmentStress-induced reductionExcitatory responsesSpine densityApical dendritesPostsynaptic currentsDendritic fieldsExcitatory inputsPyramidal cellsAntagonist RU486Selective atrophy
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