Ferdi Kiral
Associate Research Scientist in GeneticsAbout
Research
Publications
2025
KIAA0319 plays a critical role in cortical neuronal maturation and synaptic development through a dyslexia-associated gene network
Scandura M, Choe M, Kiral F, Lo C, Kim J, Yang W, Qiu C, Ma Y, Gruen J, Park I. KIAA0319 plays a critical role in cortical neuronal maturation and synaptic development through a dyslexia-associated gene network. Biological Psychiatry 2025 PMID: 41115623, DOI: 10.1016/j.biopsych.2025.10.014.Peer-Reviewed Original ResearchHuman cortical organoidsNeuronal maturationScRNA-seqHuman embryonic stem cellsImpaired neuronal maturationPrimary cilia formationSingle-cell RNA sequencingNeural progenitor cellsDyslexia-associated genesEmbryonic stem cellsDisrupted neurogenesisRegulatory networksGene networksProgenitor cellsCalcium imagingCilia formationTranscriptome analysisRNA sequencingTranscriptomic changesStem cellsSynaptic developmentCortical organoidsMolecular basisKIAA0319Morphological abnormalitiesRadiofrequency regulates the BET-mediated pathways in radial glia differentiation in human cortical development
Cakir B, Tanaka Y, Choe M, Kiral F, Kim J, Micali N, Kang Y, Dharmadhikari B, Patterson B, Yang W, Cho Y, Xiang Y, Zhong M, Lee S, Patra P, Rakic P, Park I. Radiofrequency regulates the BET-mediated pathways in radial glia differentiation in human cortical development. Cell Reports 2025, 44: 116238. PMID: 40997800, DOI: 10.1016/j.celrep.2025.116238.Peer-Reviewed Original ResearchConceptsHuman cortical organoidsHuman embryonic stem cellsExpression of human endogenous retrovirusesBrain developmentStem Cell Self-RenewalRadial glia progenitorsNeural Stem Cell Self-RenewalCell Self-RenewalHuman cortical developmentHuman endogenous retrovirusesEmbryonic stem cellsStem cell identityCortical developmentGlia progenitorsPrenatal stressSelf-RenewalStem cellsCortical organoidsNon-genetic factorsGlia differentiationDevelopmental defectsEndogenous retrovirusesBrainRadiofrequencyDelayed differentiation
2024
Telencephalic organoids as model systems to study cortical development and diseases
Yang W, Kiral F, Park I. Telencephalic organoids as model systems to study cortical development and diseases. Organoid 2024, 4: e1. DOI: 10.51335/organoid.2024.4.e1.Peer-Reviewed Original Research
2023
Diencephalic organoids – A key to unraveling development, connectivity, and pathology of the human diencephalon
Kiral F, Choe M, Park I. Diencephalic organoids – A key to unraveling development, connectivity, and pathology of the human diencephalon. Frontiers In Cellular Neuroscience 2023, 17: 1308479. PMID: 38130869, PMCID: PMC10733522, DOI: 10.3389/fncel.2023.1308479.Peer-Reviewed Original ResearchHuman diencephalonBrain organoidsNeurodevelopmental disordersDevelopmental brain disordersHuman brain tissueThalamocortical connectionsBrain disordersDiencephalic developmentBrain tissueDiencephalic structuresOrganoid modelsHuman-specific aspectsSensory processingDiencephalonDisordersTelencephalic fatePathologyStem cellsStem cell technologyOrganoidsGeneration of ventralized human thalamic organoids with thalamic reticular nucleus
Kiral F, Cakir B, Tanaka Y, Kim J, Yang W, Wehbe F, Kang Y, Zhong M, Sancer G, Lee S, Xiang Y, Park I. Generation of ventralized human thalamic organoids with thalamic reticular nucleus. Cell Stem Cell 2023, 30: 677-688.e5. PMID: 37019105, PMCID: PMC10329908, DOI: 10.1016/j.stem.2023.03.007.Peer-Reviewed Original ResearchConceptsHuman embryonic stem cellsSingle-cell RNA sequencingReceptor tyrosine protein kinaseTyrosine protein kinaseEmbryonic stem cellsDisease-associated genesLineage developmentRNA sequencingHuman brain developmentOrganoid systemsStem cellsHuman brain organoidsNeuronal functionBrain organoidsOrganoidsBrain organoid systemsDistinct nucleiBrain developmentThalamic developmentPTCHD1NucleusKinaseGenesSequencing
2022
Advanced in vitro models: Microglia in action
Cakir B, Kiral F, Park I. Advanced in vitro models: Microglia in action. Neuron 2022, 110: 3444-3457. PMID: 36327894, DOI: 10.1016/j.neuron.2022.10.004.Peer-Reviewed Original Research
2021
Brain connectivity inversely scales with developmental temperature in Drosophila
Kiral F, Dutta S, Linneweber G, Hilgert S, Poppa C, Duch C, von Kleist M, Hassan B, Hiesinger P. Brain connectivity inversely scales with developmental temperature in Drosophila. Cell Reports 2021, 37: 110145. PMID: 34936868, DOI: 10.1016/j.celrep.2021.110145.Peer-Reviewed Original ResearchSystematic functional analysis of Rab GTPases reveals limits of neuronal robustness to environmental challenges in flies
Kohrs F, Daumann I, Pavlovic B, Jin E, Kiral F, Lin S, Port F, Wolfenberg H, Mathejczyk T, Linneweber G, Chan C, Boutros M, Hiesinger P. Systematic functional analysis of Rab GTPases reveals limits of neuronal robustness to environmental challenges in flies. ELife 2021, 10: e59594. PMID: 33666175, PMCID: PMC8016483, DOI: 10.7554/elife.59594.Peer-Reviewed Original ResearchConceptsRab GTPasesMembrane traffickingSystematic functional analysisObvious morphological defectsAutophagy-independent roleMutant collectionNull mutantsFertile fliesMaintenance defectsGTPasesNeuronal robustnessFunctional analysisMolecular switchMorphological defectsUnknown functionHalf exhibitMutantsFliesNeuronal functionGenesTraffickingEnvironmental challengesRabRab26Nervous system
2020
Generation and characterization of inner photoreceptor‐specific enhancer‐trap lines using a novel piggyBac‐Gal4 element in Drosophila
Kara E, Kiral F, Çolak A, Çelik A. Generation and characterization of inner photoreceptor‐specific enhancer‐trap lines using a novel piggyBac‐Gal4 element in Drosophila. Archives Of Insect Biochemistry And Physiology 2020, 104: e21675. PMID: 32285519, DOI: 10.1002/arch.21675.Peer-Reviewed Original ResearchAutophagy-dependent filopodial kinetics restrict synaptic partner choice during Drosophila brain wiring
Kiral F, Linneweber G, Mathejczyk T, Georgiev S, Wernet M, Hassan B, von Kleist M, Hiesinger P. Autophagy-dependent filopodial kinetics restrict synaptic partner choice during Drosophila brain wiring. Nature Communications 2020, 11: 1325. PMID: 32165611, PMCID: PMC7067798, DOI: 10.1038/s41467-020-14781-4.Peer-Reviewed Original Research
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