Mei Zhong, PhD
Associate Research Scientist in Cell BiologyCards
About
Research
Publications
2026
Large-scale, spatially resolved panoramic CRISPR screening in native tissue environments using Perturb-DBiT
Baysoy A, Tian X, Renauer P, Zhang F, Bai Z, Shi H, Yang M, Zhang D, Liu M, Li H, Tao B, Enninful A, Lu Y, Gao F, Wang G, Zhang W, Tran T, Patterson N, Sheng J, Bao S, Dong C, Xin S, Chen B, Zhong M, Rankin S, Guy C, Wang Y, Connelly J, Pruett-Miller S, Wang D, Xu M, Gerstein M, Chi H, Chen S, Fan R. Large-scale, spatially resolved panoramic CRISPR screening in native tissue environments using Perturb-DBiT. Nature Biotechnology 2026, 1-14. PMID: 42277225, DOI: 10.1038/s41587-026-03127-y.Peer-Reviewed Original ResearchThis study introduces Perturb-DBiT, a method enabling spatially resolved CRISPR screens and transcriptomics in tissues, uncovering genetic and RNA-level mechanisms driving cancer and immune interactions.Genetic dissection of clinical heterogeneity in Hemoglobin H patients by targeted long-read sequencing
Ye Y, Niu C, Mao A, Chen L, Qin L, Chen W, Liu Z, Xie T, Long Y, Shang X, Huang Y, Zhang Q, Chen L, Luo H, Li Y, Lu Y, Liu Y, Liao L, Cai J, Liu R, Zhang X, Zeng L, Li Y, Chen J, Zhong Z, Fang J, Li X, Yang X, Lin B, Li K, Hua X, Huang B, Qin H, Huang Y, Huang Z, Lao J, Qu X, Chen J, Feng X, Liu Q, Lin W, Zhou X, Liang Y, Long X, Qin J, Yan L, Zhu W, Yu L, Fan C, Tang D, Zhong T, Tan J, Ren Z, Gao Y, Xu X. Genetic dissection of clinical heterogeneity in Hemoglobin H patients by targeted long-read sequencing. Journal Of Genetics And Genomics 2026 PMID: 42035796, DOI: 10.1016/j.jgg.2026.04.011.Peer-Reviewed Original ResearchCorrigendum “Glycyrrhetinic acid inhibits non-small cell lung cancer via promotion of Prdx6- and caspase-3-mediated mitochondrial apoptosis” [Biomed. Pharmacother., 173 (2024) 116304]
Guo Q, Zhao M, Wang Q, Lu T, Luo P, Chen L, Xia F, Pang H, Shen S, Cheng G, Dai C, Meng Y, Zhong T, Qiu C, Wang J. Corrigendum “Glycyrrhetinic acid inhibits non-small cell lung cancer via promotion of Prdx6- and caspase-3-mediated mitochondrial apoptosis” [Biomed. Pharmacother., 173 (2024) 116304]. Biomedicine & Pharmacotherapy 2026, 196: 119162. PMID: 41748410, DOI: 10.1016/j.biopha.2026.119162.Commentaries, Editorials and Letters
2025
Generation of human pineal gland organoids with melatonin production for disease modeling
Kiral F, Yang W, Iyilikci O, Lu X, Kim J, Choe M, Lo C, Zhong M, Kim K, Jiang Y, Park I. Generation of human pineal gland organoids with melatonin production for disease modeling. Cell Stem Cell 2025, 33: 91-107.e9. PMID: 41475351, PMCID: PMC12925488, DOI: 10.1016/j.stem.2025.12.004.Peer-Reviewed Original ResearchSpatial dynamics of brain development and neuroinflammation
Zhang D, Rubio Rodríguez-Kirby L, Lin Y, Wang W, Song M, Wang L, Wang L, Kanatani S, Jimenez-Beristain T, Dang Y, Zhong M, Kukanja P, Bao S, Wang S, Chen X, Gao F, Wang D, Xu H, Ma C, Lou X, Liu Y, Chen J, Sestan N, Uhlén P, Kriegstein A, Zhao H, Castelo-Branco G, Fan R. Spatial dynamics of brain development and neuroinflammation. Nature 2025, 647: 213-227. PMID: 41193846, PMCID: PMC12589135, DOI: 10.1038/s41586-025-09663-y.Peer-Reviewed Original ResearchImpact of transferrin levels on iron accumulation in transfusion-dependent beta-thalassemia: A genotype-specific analysis
Liang Y, Zhang X, Huang B, Huang Y, Liao L, Huang Y, Huang K, Lao J, Feng X, Lin B, Long X, Liu Z, Zhu W, Yu L, Tang D, Zhong T, Ye Y, Xu X. Impact of transferrin levels on iron accumulation in transfusion-dependent beta-thalassemia: A genotype-specific analysis. Journal Of Medical Biochemistry 2025, 44: 1575-1589. PMID: 41281279, PMCID: PMC12639517, DOI: 10.5937/jomb0-54839.Peer-Reviewed Original ResearchRadiofrequency regulates the BET-mediated pathways in radial glia differentiation in human cortical development
Cakir B, Tanaka Y, Choe M, Kiral F, Kim J, Micali N, Kang Y, Dharmadhikari B, Patterson B, Yang W, Cho Y, Xiang Y, Zhong M, Lee S, Patra P, Rakic P, Park I. Radiofrequency regulates the BET-mediated pathways in radial glia differentiation in human cortical development. Cell Reports 2025, 44: 116238. PMID: 40997800, PMCID: PMC12959456, DOI: 10.1016/j.celrep.2025.116238.Peer-Reviewed Original ResearchFeasibility of machine learning–based modeling and prediction to assess osteosarcoma outcomes
Zhao Q, Hu W, Xia Y, Dai S, Wu X, Chen J, Yuan X, Zhong T, Xi X, Wang Q. Feasibility of machine learning–based modeling and prediction to assess osteosarcoma outcomes. Scientific Reports 2025, 15: 17386. PMID: 40389469, PMCID: PMC12089500, DOI: 10.1038/s41598-025-00179-z.Peer-Reviewed Original ResearchNanobody Engineered and Photosensitiser Loaded Bacterial Outer Membrane Vesicles Potentiate Antitumour Immunity and Immunotherapy
Xia P, Qu C, Xu X, Tian M, Li Z, Ma J, Hou R, Li H, Rückert F, Zhong T, Zhao L, Yuan Y, Wang J, Li Z. Nanobody Engineered and Photosensitiser Loaded Bacterial Outer Membrane Vesicles Potentiate Antitumour Immunity and Immunotherapy. Journal Of Extracellular Vesicles 2025, 14: e70069. PMID: 40240911, PMCID: PMC12003094, DOI: 10.1002/jev2.70069.Peer-Reviewed Original ResearchFunctional Validation of Alcohol Dependence-Associated FYN Variants Using Gene Editing and Stem Cell Study Approaches
Cakir B, Tanaka Y, Choe M, Chu P, Xiang Y, Kim K, Zhong M, Gelernter J, Zhang H, Krystal J, Park I. Functional Validation of Alcohol Dependence-Associated FYN Variants Using Gene Editing and Stem Cell Study Approaches. International Journal Of Stem Cells 2025, 18: 263-274. PMID: 40205763, PMCID: PMC12394083, DOI: 10.15283/ijsc24123.Peer-Reviewed Original Research
Get In Touch
Contacts
Email