About
Titles
Assistant Professor
Biography
Evangelos K. Oikonomou, M.D., D.Phil. is a cardiologist and physician-scientist, and an Assistant Professor of Medicine in the Section of Cardiovascular Medicine at Yale School of Medicine, where he leads a lab working on dissecting cardiometabolic disease through artificial intelligence–enabled digital biomarkers. He is also a Deputy Editor of the European Heart Journal. His work focuses on the development and clinical translation of artificial intelligence-enabled digital biomarkers, with an emphasis on computer vision applications for precision phenotyping in cardiovascular disease. His research aims to create scalable, cost-effective tools that integrate seamlessly into routine clinical workflows to improve diagnosis, risk stratification, and therapeutic decision-making.
He received his M.D. degree as valedictorian from the University of Athens and his Ph.D. (D.Phil.) in Medical Sciences from the University of Oxford. He subsequently completed the Yale Physician-Scientist Training Program, including residency training in Internal Medicine and clinical and postdoctoral fellowship training in Cardiovascular Medicine. His research is supported by a Career Development Award (K23) from the National Heart, Lung, and Blood Institute, with additional funding from the American Heart Association, the Yale Claude D. Pepper Older Americans Independence Center, and Wellcome Leap (through the VISIBLE program).
He has received multiple national and international honors, including Young Investigator Awards from the American Heart Association, the European Society of Cardiology, and the Society of Cardiovascular Computed Tomography; the American Society for Clinical Investigation Emerging Generation Award; and the Wiesman Award from the ATTR Early-Career Research Forum.
His interdisciplinary research lies at the intersection of cardiovascular and cardiometabolic medicine and focuses on four major areas: (i) the development and clinical translation of adipose tissue imaging biomarkers to elucidate the early links between adiposity and cardiovascular disease; (ii) the design and validation of deep learning algorithms for point-of-care echocardiography to detect both common and under-recognized cardiomyopathies; (iii) the data-driven evaluation of treatment-effect heterogeneity in clinical trials to inform adaptive and precision-enriched trial design; and (iv) the multimodal integration of these approaches into clinical care pathways through innovative clinical informatics approaches.
His work has been published in the Lancet, Lancet Digital Health, JAMA, NEJM AI, JAMA Cardiology, Eur Heart J, JACC, Circulation, and Diabetes Care, among others.
Looking ahead, his research is focused on leveraging multimodal AI to redefine diagnostic and prognostic frameworks across the cardiovascular disease spectrum, from subclinical detection to dynamic risk prediction, with a strong emphasis on real-world implementation and equitable access to advanced diagnostics.
A complete list of publications is available at: https://scholar.google.com/citations?user=GgJv1SMAAAAJ&hl=en
An overview of his lab can be found here: https://oikonomou-lab.org/
Departments & Organizations
- ABIM Physician-Scientist Research Pathway
- Internal Medicine
- Janeway Society
- Yale Medicine
- Yale New Haven Health System
Education & Training
- Clinical fellow
- Yale School of Medicine (2025)
- Post-doctoral fellow
- Yale School of Medicine (2025)
- Resident
- Yale School of Medicine (2021)
- Intern
- Yale School of Medicine (2020)
- DPhil
- University of Oxford (2020)
- MD
- University of Athens School of Health Sciences (2015)
Board Certifications
Cardiovascular Disease
- Certification Organization
- AB of Internal Medicine
- Original Certification Date
- 2025
Internal Medicine
- Certification Organization
- AB of Internal Medicine
- Original Certification Date
- 2022
Research
Overview
Medical Research Interests
Academic Achievements & Community Involvement
News & Links
News
- September 09, 2026
Shah, Lansky, and Oikonomou Join VISIBLE Network
- August 12, 2026
Yale Center for Clinical Investigation Names 2026 Scholars
- June 18, 2026
Announcing the 2026 Pepper Awardees
- February 11, 2026
Using AI to Guide AI
Get In Touch
Contacts
Yale School of Medicine
100 Church St S
New Haven, CT 06519
United States
Locations
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