Emily Christison-Lagay, MD
Cards
About
Titles
Associate Professor of Surgery (Pediatrics)
Director of Pediatric Trauma, Surgery; Surgical Director, Pediatric Thyroid Center, Surgery
Biography
Emily Christison-Lagay, MD is a pediatric surgeon with broad clinical interests spanning the width pediatric surgery from congenital anomalies in newborns to common childhood surgical conditions (hernias, appendicitis, gallbladder disease) to childhood tumors, trauma, and benign and malignant thyroid disease. She is the surgical director of the Pediatric Thyroid Center at Yale and the Director of Pediatric Trauma. Following completion of her pediatric surgical training, Dr. Christison-Lagay pursued additional training in the medical and surgical management of pediatric solid tumors including thoracic, liver, and renal tumors, as well as neuroblastoma, childhood sarcomas, and pediatric diseases of the thyroid. She is board-certified in surgery and pediatric surgery,
Dr. Christison-Lagay completed her medical degree at Harvard Medical School and her general surgical residency at the Massachusetts General Hospital, with research in tumor angiogenesis at Boston Children's Hospital. From there, she completed a pediatric surgical fellowship at the Hospital for Sick Children in Toronto, followed by a "super"-fellowship in pediatric surgical oncology at Memorial Sloan Kettering Cancer Center. She is a member of the Children's Oncology Group and the International Society of Paediatric Surgical Oncology as well the American Thyroid Association Taskforce on Pediatric Thyroid Disease and a founding member of the Child and Adolescent Thyroid Consortium.
Appointments
Pediatric Surgery
Associate Professor on TermPrimaryPediatrics
Associate Professor on TermSecondary
Other Departments & Organizations
- Fetal Care Center
- General Pediatric & Thoracic Surgery
- Pediatric Aerodigestive Disorders Program
- Pediatric Inflammatory Bowel Disease Surgery Program
- Pediatric Surgery
- Pediatric Surgery
- Pediatric Trauma Surgery Program
- Pediatrics
- Surgery
- Yale Medicine
- Yale New Haven Health System
- Yale Ventures
Education & Training
- Fellowship
- Memorial Sloan Kettering Cancer Center (2012)
- Fellowship
- Hospital for Sick Children (2011)
- Residency
- Massachusetts General Hospital (2009)
- MD
- Harvard Medical School (2002)
Research
Publications
2026
Rare Tumors Part One
Arnold E, Englum B, Christison-Lagay E, Aldrink J. Rare Tumors Part One. Surgical Oncology Clinics Of North America 2026 DOI: 10.1016/j.soc.2026.04.014.Peer-Reviewed Original ResearchVariation in Management of Blunt Splenic Injury by Trauma Center Training Status.
Hellmann Z, Sohi G, Thaxton C, Jones A, Christison-Lagay E, Solomon D. Variation in Management of Blunt Splenic Injury by Trauma Center Training Status. Journal Of The American College Of Surgeons 2026, 242: 1498-1504. PMID: 41562442, DOI: 10.1097/xcs.0000000000001779.Peer-Reviewed Original ResearchBlunt splenic injuryNon-operative managementManagement of blunt splenic injuryPediatric Health Information SystemSplenic injuryInjury Severity ScoreSurgical managementPatient demographicsNon-operative management of blunt splenic injuryFailure of non-operative managementPediatric blunt splenic injuryPercutaneous endovascular embolizationSevere splenic injuriesPediatric trauma surgeonICD-10 diagnostic codesHealth information systemsInjury severityMultivariate logistic regressionRates of interventionSplenic interventionEndovascular embolizationFellowship training programsSurgical fellowshipsSurgical interventionInterinstitutional variabilityThe landscape of pediatric differentiated thyroid carcinoma and predictors of invasive disease: a CATC study
Wasserman J, Isaza A, Waguespack S, Wassner A, Franco A, Christison-Lagay E, Dinauer C, Baran J, Bojarsky M, Bauer A. The landscape of pediatric differentiated thyroid carcinoma and predictors of invasive disease: a CATC study. The Journal Of Clinical Endocrinology & Metabolism 2026, dgag172. PMID: 42025318, DOI: 10.1210/clinem/dgag172.Peer-Reviewed Original ResearchDifferentiated thyroid carcinomaPapillary thyroid carcinomaFollicular thyroid carcinomaPredictors of invasive diseaseMulticenter retrospective analysisThyroid carcinomaExtrathyroidal extensionInvasive diseasePediatric DTCOncogenic fusionsRetrospective analysis of childrenAssociated with age <Papillary thyroid carcinoma patientsDisease outcomeDeintensification of therapyTumor characteristicsPulmonary metastasesAdvanced TAggressive therapyAnalysis of childrenMale sexAdvanced NCarcinomaTreatment outcomesCase volumeImplementing an Education Intervention for Prescription Opioid Pain Medication at Pediatric Trauma Centers
Mello M, Baird J, Spirito A, Scott K, Zonfrillo M, Lee L, Kiragu A, Christison-Lagay E, Bromberg J, Ruest S, Pruitt C, Lawson K, Nasr I, Aidlen J, Becker S. Implementing an Education Intervention for Prescription Opioid Pain Medication at Pediatric Trauma Centers. Substance Use & Misuse 2026, ahead-of-print: 1-6. PMID: 41481074, DOI: 10.1080/10826084.2025.2609292.Peer-Reviewed Original ResearchOpioid pain medicationsPediatric trauma centerMedical educationPain medicationTrauma centerEducational interventionOpioid prescribingOpioid pain medication useAdolescent patientsPrescription opioid pain medicationPreventive educational interventionsPain medication useIntervention implementationOpioid overdose deathsPost-implementationPositive screenPain managementMedication useTrained staffHospital dischargeOpioidInterventionOverdose deathsFamily membersMedicationMulticenter Histology Image Integration and Multiscale Deep Learning Support Machine Learning-Enabled Pediatric Sarcoma Classification
Thiesen A, Domanskyi S, pour A, Zhang J, Sheridan T, Neuhauser S, Stetson A, Dannheim K, Henriksen J, Cameron D, Ahn S, Wu H, Lagay E, Bult C, Chen E, Chuang J, Rubinstein J. Multicenter Histology Image Integration and Multiscale Deep Learning Support Machine Learning-Enabled Pediatric Sarcoma Classification. Cancer Research 2026, 86: 1797-1810. PMID: 41481196, PMCID: PMC12893192, DOI: 10.1158/0008-5472.can-25-2275.Peer-Reviewed Original ResearchConvolutional neural networkWhole slide imagesMultiple convolutional neural networksTransformer encoder architectureTwo-stage pipelineDeep learning methodsEncoder architectureFeature extractorVision TransformerImage harmonizationClassifier generalizabilityClassification accuracyNeural networkMultiscale featuresLearning methodsDigital histopathologySlide imagesClassifierArchitectureClassificationRepresentationImagesGPUPipelineExtractorInterval appendectomy practices for complicated appendicitis in children: a systematic review from the APSA Outcomes and Evidence-Based Practice Committee
Sulkowski J, Huerta C, Tashiro J, Diesen D, Gulack B, Christison-Lagay E, Russell K, Alemayehu H, Polites S, Hey M, Chang H, Beres A, Ignacio R, Lucas D, Kabagambe S, Baird R, Kulaylat A, Mansfield S, Rentea R, Pennell C, Rich B, Yousef Y, Ricca R, Kelley-Quon L, Levene T. Interval appendectomy practices for complicated appendicitis in children: a systematic review from the APSA Outcomes and Evidence-Based Practice Committee. Pediatric Surgery International 2026, 42: 205. PMID: 42043565, PMCID: PMC13121297, DOI: 10.1007/s00383-026-06445-z.Peer-Reviewed Original ResearchConceptsNon-operative managementIncidence of appendiceal neoplasmsInterval appendectomyComplicated appendicitisCochrane Central RegisterMethodsA systematic reviewRecurrent appendicitisAppendiceal neoplasmsIncidence of recurrent appendicitisRisk of recurrent diseaseRisk factorsCochrane Central Register of Controlled TrialsCentral Register of Controlled TrialsRisk of neoplasmRegister of Controlled TrialsSystematic review of English-language articlesDisease-related risk factorsReview of English-language articlesTime of IAEnglish-language articlesRoutine IAMethodsA systematic review of English language articlesNeuroendocrine tumorsRecurrent diseaseSurgical risk
2025
Factors Associated With Rare Pediatric Cancer Trial Enrollment: A Report From the Children's Oncology Group Rare Tumors Committee
Englum B, Piao J, Younis L, Baertschiger R, Chen K, Christison‐Lagay E, Dholaria H, Gartrell R, Hicks M, Kamihara J, Mitchell S, Orjuela‐Grimm M, Pashankar F, Potter S, Aldrink J, Rosenblum J, Sargen M, Schultz K, Seynnaeve B, Wedekind M, Laetsch T. Factors Associated With Rare Pediatric Cancer Trial Enrollment: A Report From the Children's Oncology Group Rare Tumors Committee. Pediatric Blood & Cancer 2025, 73: e32164-e32164. PMID: 41451685, PMCID: PMC13034881, DOI: 10.1002/pbc.32164.Peer-Reviewed Original ResearchConceptsChildren's Oncology GroupRare cancersTherapeutic trialsAdrenocortical carcinomaNasopharyngeal carcinomaBiobank studyChildren's Oncology Group studyPatient geographyUS childrenTrial accrualUS populationRare Tumor CommitteeUS incidenceEnd ResultsPatient characteristicsDemographic dataTumor CommitteeUS patientsOncology GroupThyroid carcinomaEnrollmentMolecular testingTrial developmentCarcinomaCancerComparing injury severity scores from trauma registries with those mapped from injury diagnosis codes in injured adolescents
Zonfrillo M, Baird J, Spirito A, Scott K, Lee L, Kiragu A, Christison-Lagay E, Bromberg J, Ruest S, Pruitt C, Lawson K, Nasr I, Aidlen J, Maxson R, Becker S, Mello M. Comparing injury severity scores from trauma registries with those mapped from injury diagnosis codes in injured adolescents. Injury Prevention 2025, 32: 348-351. PMID: 41386800, PMCID: PMC13138516, DOI: 10.1136/ip-2024-045525.Peer-Reviewed Original ResearchInjury Severity ScoreTrauma registryAbbreviated Injury ScaleInternational ClassificationInternational Classification of Diseases (ICD)Electronic health recordsInjury diagnosis codePaediatric trauma centreAbbreviated Injury Scale scoreAdolescent trauma patientsSeverity scoreHealth recordsInjury Severity Score valuesInjury severity classificationClinical careDiagnosis codesTrauma centreQuality improvementICD-10Injury ScaleRegistryISS valuesInjury severityDescriptive analysisTrauma patientsManagement of perianal abscesses in infants: A systematic review from the APSA outcomes and evidence-based practice committee
Acker S, Sulkowski J, Chang H, Cyrus J, Christison-Lagay E, Mansfield S, Diesen D, Gulack B, Russell K, Beres A, Rentea R, Yousef Y, Alemayehu H, Danko M, Kabagambe S, Kulaylat A, Levene T, Pennell C, Polites S, Ramjist J, Rich B, Scholz S, Skarda D, Tashiro J, Hey M, Ignacio R, Baird R, Kelley-Quon L, Ricca R, Committee T. Management of perianal abscesses in infants: A systematic review from the APSA outcomes and evidence-based practice committee. Journal Of Pediatric Surgery 2025, 60: 162691. PMID: 40983150, DOI: 10.1016/j.jpedsurg.2025.162691.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsFistula-in-anoManagement of perianal abscessNon-operative approachNonoperative managementPerianal abscessPerianal diseaseAmerican Pediatric Surgical Association OutcomesManagement of fistula-in-anoFailure of nonoperative managementSystematic reviewPractice CommitteeRecurrence rateSurgical managementTreatment strategiesAbscessOperative interventionApproaches to managementPreferred Reporting ItemsConsensus-based questionsComprehensive search strategyRecurrenceCase-by-case basisReporting ItemsInfantsAssociated outcomesArnold Schwarzenegger or Danny DeVito? The fate of twins with necrotizing enterocolitis in the NICU
Hellmann Z, Thaxton C, Sapir N, Rehman S, Cowles R, Christison-Lagay E, Solomon D. Arnold Schwarzenegger or Danny DeVito? The fate of twins with necrotizing enterocolitis in the NICU. Journal Of Pediatric Surgery 2025, 61: 162526. PMID: 40812408, DOI: 10.1016/j.jpedsurg.2025.162526.Peer-Reviewed Original ResearchMultiple gestation pregnanciesGestation pregnanciesSingleton birthsUncontrolled cohortIncidence of necrotizing enterocolitisNeonatal intensive care unitDevelopment of NECIncidence of NECPediatric Health Information SystemIntensive care unitSingleton gestationsGestational ageMultiple gestationsNICU populationSingleton infantsNecrotizing enterocolitisNICU infantsLow birthweightAverage birthweightInternal validityPrimary outcomeGestationCare unitShort gestationInfants
Clinical Care
Overview
Emily Christison-Lagay, MD, is a pediatric surgeon with broad clinical interests spanning the width of pediatric surgery from congenital anomalies in newborns to common childhood surgical conditions (hernias, appendicitis, gallbladder disease) to childhood tumors, trauma, and benign and malignant thyroid disease. She is board-certified in surgery and pediatric surgery and has pursued additional training in the medical and surgical management of pediatric solid tumors including thoracic, liver, and renal tumors, as well as neuroblastoma, childhood sarcomas, and pediatric diseases of the thyroid.
She completed her medical degree at Harvard Medical School and her general surgical residency at the Massachusetts General Hospital, with research in tumor angiogenesis at Boston Children's Hospital. From there, she completed a pediatric surgical fellowship at the Hospital for Sick Children in Toronto, followed by a "super" fellowship in pediatric surgical oncology at Memorial Sloan Kettering Cancer Center. She is a member of both the Children's Oncology Group and the American Thyroid Association Taskforce on Pediatric Thyroid Disease.
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Pediatric Surgery
PO Box 208062
New Haven, CT 06520-8062
United States
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