Diana Núñez
Postdoctoral AssociateAbout
Research
Publications
2025
DECODING RARE CNVS AND THEIR FUNCTIONAL INSIGHTS IN MAJOR DEPRESSIVE DISORDER FROM LATIN AMERICAN COHORTS
Nunez-Rios D, Nagamatsu S, Martínez-Magaña J, Nicolini H, Delia A, Lattig M, Marquez Y, Ferro E, Martinez K, Guisti P, group L, group P, Fernandez T, Montalvo-Ortiz J. DECODING RARE CNVS AND THEIR FUNCTIONAL INSIGHTS IN MAJOR DEPRESSIVE DISORDER FROM LATIN AMERICAN COHORTS. European Neuropsychopharmacology 2025, 99: 10. DOI: 10.1016/j.euroneuro.2025.08.472.Peer-Reviewed Original ResearchGenome-wide association studiesCopy-number variationsDosage-sensitive genesSingle nucleotide variantsMDD-associated genesDatabase of Genomic VariantsRare copy-number variationsCopy-number variation studyDiscovery of risk variantsComplex admixture patternsGenomes Project dataAdmixed Latin AmericansFunctional relevancePotential functional relevanceAncestry inferenceAdmixture patternsGenetic diversityGenomic variantsNucleotide variantsPopulation stratificationAssociation studiesGene regulationDNA sequencesCoding regionGenetic rearrangementsM11. MULTI-OMICS ANALYSIS OF ADVERSE CHILDHOOD EXPERIENCES (ACE) IN THE ORBITOFRONTAL CORTEX (OFC) OF HUMAN POSTMORTEM BRAIN
Nunez-Rios D, Jimenez L, Luppino J, Nagamatsu S, Martínez-Magaña J, Group T, Montalvo-Ortiz J. M11. MULTI-OMICS ANALYSIS OF ADVERSE CHILDHOOD EXPERIENCES (ACE) IN THE ORBITOFRONTAL CORTEX (OFC) OF HUMAN POSTMORTEM BRAIN. European Neuropsychopharmacology 2025, 99: 114. DOI: 10.1016/j.euroneuro.2025.08.207.Peer-Reviewed Original ResearchPost-traumatic stress disorderSubstance use disordersComorbidity of post-traumatic stress disorderAdverse childhood experiencesAssociated with adverse childhood experiencesOrbitofrontal cortexUse disorderExposure to adverse childhood experiencesPostmortem brainsAdverse childhood experience exposureDevelopment of substance use disordersPostmortem brains of individualsAlcohol use disorderHuman postmortem brainBrains of individualsOFC neuronsOpioid use disorderEmotion regulationStress disorderBrain regionsMental disordersFluorescence-activated nuclei sortingPolysubstance useChildhood experiencesCell-type specificityM13. DISENTANGLING THE PREFRONTAL CORTEX MULTI-OMIC PROFILE OF OPIOID MISUSE AND POST-TRAUMATIC STRESS DISORDER COMORBIDITY
Martinez-Magana J, Nagamatsu S, Rivera-Hernández M, Núñez-Ríos D, Krystal J, Girgenti M, Group T, Montalvo-Ortiz J. M13. DISENTANGLING THE PREFRONTAL CORTEX MULTI-OMIC PROFILE OF OPIOID MISUSE AND POST-TRAUMATIC STRESS DISORDER COMORBIDITY. European Neuropsychopharmacology 2025, 99: 115-116. DOI: 10.1016/j.euroneuro.2025.08.209.Peer-Reviewed Original ResearchPost-traumatic stress disorderDorsal anterior cingulate cortexPrefrontal cortexHuman prefrontal cortexOrbitofrontal cortexOpioid use disorderComorbid groupPost-traumatic stress disorder comorbidityContext of post-traumatic stress disorderAssociated with post-traumatic stress disorderSubgenual prefrontal cortexAnterior cingulate cortexDorsolateral prefrontal cortexAssociated with opioid misuseAddiction cycleFear processingPTSD symptomsCingulate cortexStress disorderUse disorderSymptom severityBrain regionsCholinergic systemSgPFCOpioid misuseA META-ANALYSIS OF GENOME-WIDE ASSOCIATION STUDIES OF DEPRESSION IN LATIN AMERICAN COHORTS: PRELIMINARY RESULTS FROM THE MDD WORKING GROUP OF THE LATIN AMERICAN GENOMICS CONSORTIUM
Corral-Frias N, Singh M, Chatzinakos C, Cárcamo J, Amaya L, de Oliveira A, Nuñez-Rios D, Ota V, Nagamatsu S, Toledo M, Bigdeli T, Martinez-Levy G, Lattig M, Montalvo-Ortiz J, Peterson R. A META-ANALYSIS OF GENOME-WIDE ASSOCIATION STUDIES OF DEPRESSION IN LATIN AMERICAN COHORTS: PRELIMINARY RESULTS FROM THE MDD WORKING GROUP OF THE LATIN AMERICAN GENOMICS CONSORTIUM. European Neuropsychopharmacology 2025, 99: 12. DOI: 10.1016/j.euroneuro.2025.08.475.Peer-Reviewed Original ResearchGenome-wide association studiesGenome-wide association study meta-analysisMeta-analysis of genome-wide association studiesGenetic admixtureAssociation studiesMental health equityBuilding Research CapacityBurden of depressionIndividuals of European descentPsychiatric genetic researchMental health outcomesWorking GroupGWAS Meta-AnalysisGenome analysis pipelineLatin American ancestryHealth equityHealthcare disparitiesHealth outcomesGeneralizability of findingsDepressive phenotypeSelf-report measuresResearch capacityGlobal disparitiesDiverse cohortEuropean descentIntegrated Gene and Isoform-Level Transcriptomic Analysis of Adverse Childhood Experiences in the Human Prefrontal Cortex
Núñez-Ríos D, Nagamatsu S, Martínez-Magaña J, Montalvo-Ortiz J. Integrated Gene and Isoform-Level Transcriptomic Analysis of Adverse Childhood Experiences in the Human Prefrontal Cortex. The Yale Journal Of Biology And Medicine 2025, 98: 89-103. PMID: 40589944, PMCID: PMC12204229, DOI: 10.59249/vlmz6974.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderAdverse childhood experiencesPsychiatric disordersChildhood experiencesIncreased risk of psychiatric disordersPostmortem brains of individualsRisk of psychiatric disordersAdverse childhood experience historyDorsal anterior cingulateAssociated with adverse childhood experiencesComplex psychiatric disorderHuman prefrontal cortexBrains of individualsPrefrontal cortexAnterior cingulateStress disorderPostmortem brainsSgPFCDisordersNeurogenesis regulationOFCIsoform usageDysregulationDLPFCDiverse outcomesPsychiatric genetics in the diverse landscape of Latin American populations
Bruxel E, Rovaris D, Belangero S, Chavarría-Soley G, Cuellar-Barboza A, Martínez-Magaña J, Nagamatsu S, Nievergelt C, Núñez-Ríos D, Ota V, Peterson R, Sloofman L, Adams A, Albino E, Alvarado A, Andrade-Brito D, Arguello-Pascualli P, Bandeira C, Bau C, Bulik C, Buxbaum J, Cappi C, Corral-Frias N, Corrales A, Corsi-Zuelli F, Crowley J, Cupertino R, da Silva B, De Almeida S, De la Hoz J, Forero D, Fries G, Gelernter J, González-Giraldo Y, Grevet E, Grice D, Hernández-Garayua A, Hettema J, Ibáñez A, Ionita-Laza I, Lattig M, Lima Y, Lin Y, López-León S, Loureiro C, Martínez-Cerdeño V, Martínez-Levy G, Melin K, Moreno-De-Luca D, Muniz Carvalho C, Olivares A, Oliveira V, Ormond R, Palmer A, Panzenhagen A, Passos-Bueno M, Peng Q, Pérez-Palma E, Prieto M, Roussos P, Sanchez-Roige S, Santamaría-García H, Shansis F, Sharp R, Storch E, Tavares M, Tietz G, Torres-Hernández B, Tovo-Rodrigues L, Trelles P, Trujillo-ChiVacuan E, Velásquez M, Vera-Urbina F, Voloudakis G, Wegman-Ostrosky T, Zhen-Duan J, Zhou H, Santoro M, Nicolini H, Atkinson E, Giusti-Rodríguez P, Montalvo-Ortiz J. Psychiatric genetics in the diverse landscape of Latin American populations. Nature Genetics 2025, 57: 1074-1088. PMID: 40175716, PMCID: PMC12133068, DOI: 10.1038/s41588-025-02127-z.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesPsychiatric genomicsPsychiatric genome-wide association studiesLarge-scale genome-wide association studiesGenetic risk lociNon-European populationsGenetic diversityRisk lociGenetic admixtureBurden of psychiatric disordersAssociation studiesPsychiatric disordersEuropean ancestryPsychiatric geneticsGenomeHealthcare disparitiesConsortium effortLatin American populationsPromote equityEnvironmental factorsDiversityAmerican populationDiverse landscapeLociAncestry
2024
Epigenome-wide association studies identify novel DNA methylation sites associated with PTSD: a meta-analysis of 23 military and civilian cohorts
Katrinli S, Wani A, Maihofer A, Ratanatharathorn A, Daskalakis N, Montalvo-Ortiz J, Núñez-Ríos D, Zannas A, Zhao X, Aiello A, Ashley-Koch A, Avetyan D, Baker D, Beckham J, Boks M, Brick L, Bromet E, Champagne F, Chen C, Dalvie S, Dennis M, Fatumo S, Fortier C, Galea S, Garrett M, Geuze E, Grant G, Hauser M, Hayes J, Hemmings S, Huber B, Jajoo A, Jansen S, Kessler R, Kimbrel N, King A, Kleinman J, Koen N, Koenen K, Kuan P, Liberzon I, Linnstaedt S, Lori A, Luft B, Luykx J, Marx C, McLean S, Mehta D, Milberg W, Miller M, Mufford M, Musanabaganwa C, Mutabaruka J, Mutesa L, Nemeroff C, Nugent N, Orcutt H, Qin X, Rauch S, Ressler K, Risbrough V, Rutembesa E, Rutten B, Seedat S, Stein D, Stein M, Toikumo S, Ursano R, Uwineza A, Verfaellie M, Vermetten E, Vinkers C, Ware E, Wildman D, Wolf E, Young R, Zhao Y, van den Heuvel L, Uddin M, Nievergelt C, Smith A, Logue M. Epigenome-wide association studies identify novel DNA methylation sites associated with PTSD: a meta-analysis of 23 military and civilian cohorts. Genome Medicine 2024, 16: 147. PMID: 39696436, PMCID: PMC11658418, DOI: 10.1186/s13073-024-01417-1.Peer-Reviewed Original ResearchConceptsEpigenome-wide association studiesDNA methylationPsychiatric Genomics ConsortiumPost-traumatic stress disorderAssociation studiesMeta-analysis of epigenome-wide association studiesMethylation levelsGenome-wide expression dataEpigenetic gene regulationBrain regionsPGC-PTSDAnnotated genesBlood cell proportionsCpG lociGene regulationSusceptibility to post-traumatic stress disorderExpression dataAssociated with post-traumatic stress disorderIllumina HumanMethylation450Genomics ConsortiumOccurrence of post-traumatic stress disorderAssociated with biological differencesCpGMultiple brain regionsPostmortem brain samplesAncestral origins of TYR and OCA2 gene mutations in oculocutaneous albinism from two admixed populations in Colombia
Cárdenas W, Conley A, Nagar S, Núñez-Ríos D, Jordan I, Lattig M. Ancestral origins of TYR and OCA2 gene mutations in oculocutaneous albinism from two admixed populations in Colombia. PLOS ONE 2024, 19: e0313777. PMID: 39556609, PMCID: PMC11573203, DOI: 10.1371/journal.pone.0313777.Peer-Reviewed Original ResearchConceptsAncestral originTYR haplotypeAdmixed populationsOCA2 geneOCA patientsOCA2 mutationsOculocutaneous albinismAdmixed American populationsDisease-Associated VariantsGlobal reference populationsAutosomal recessive oculocutaneous albinismNative American admixtureDisease-causing mutationsNative American originGene mutationsRecessive conditionColonization historyGenetic architectureGenetic admixtureMendelian diseasesCompound heterozygote patientsAffected family membersAssociation mappingSephardic Jewish originRecessive allelesThe Prefrontal Cortex Transcriptomic Landscape of the Comorbidity Between Post-Traumatic Stress Disorder and Opioid Misuse
Martinez-Magaña J, Nagamatsu S, Nunez-Rios D, Krystal J, Girgenti M, Group T, Montalvo-Ortiz J. The Prefrontal Cortex Transcriptomic Landscape of the Comorbidity Between Post-Traumatic Stress Disorder and Opioid Misuse. Biological Psychiatry 2024, 95: s69. DOI: 10.1016/j.biopsych.2024.02.169.Peer-Reviewed Original ResearchMulti-Omics Mapping in Human Cortical Neurons Reveals Well-Known and Novel Loci of Post-Traumatic Stress Disorder
Nunez-Rios D, Hurd Y, Rompala G, Nagamatsu S, Martinez-Magaña J, Krystal J, Group T, Montalvo-Ortiz J. Multi-Omics Mapping in Human Cortical Neurons Reveals Well-Known and Novel Loci of Post-Traumatic Stress Disorder. Biological Psychiatry 2024, 95: s34. DOI: 10.1016/j.biopsych.2024.02.087.Peer-Reviewed Original Research
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