David Calfee, MD, MS, FIDSA
he/him/his
Enterprise Chief Epidemiologist, Yale New Haven Health SystemCards
About
Research
Publications
2025
Hospital-onset methicillin-resistant Staphylococcus aureus bloodstream infections within tertiary and community hospitals and implications for prevention
Singh H, Ross B, Hannah J, Ting S, Teasdale C, Wang X, Quinn M, Calfee D, Simon M, Torres H, Acker K, Horowitz H, Wang T, Gunawardhana N, Golderg R, Salazar Y, Prasad N, Jagnatnarain N, Johnson C, Kuang D, Gouveia A, Furuya Y, Westervelt K, Saiman L. Hospital-onset methicillin-resistant Staphylococcus aureus bloodstream infections within tertiary and community hospitals and implications for prevention. Infection Control And Hospital Epidemiology 2025, 47: 236-243. PMID: 41363446, PMCID: PMC12932923, DOI: 10.1017/ice.2025.10370.Peer-Reviewed Original ResearchStandardized infection ratioHO-MRSARetrospective cohort studyClinical characteristicsMethicillin-resistant Staphylococcus aureus bloodstream infections, vaMethicillin-resistant Staphylococcus aureus bloodstream infectionsSource of MRSA infectionClinical characteristics of patientsCatheter-related issuesPotential infectious sourcesCharacteristics of patientsMRSA infectionsBSI ratesPatient dischargeBloodstream infectionsPrimary outcomeSecondary outcomesInfectious sourcePatientsCare hospitalMortality rateSystematic surveillanceAcute care hospitalsPrevention strategiesInfectionInvestigation and control of an outbreak of methicillin-susceptible Staphylococcus aureus skin and soft tissue infections in a neonatal intensive care unit.
Rivera-Valenzuela G, Senaldi L, Tiwari P, Yap V, Cannon J, Saiman L, Calfee D, Marino J, Rólon R, Mitchell K, Rowlinson M, Haas W, Sankaranarayanan K, Westblade L, Acker K. Investigation and control of an outbreak of methicillin-susceptible Staphylococcus aureus skin and soft tissue infections in a neonatal intensive care unit. Infection Control And Hospital Epidemiology 2025, 47: 139-144. PMID: 41243561, DOI: 10.1017/ice.2025.10303.Peer-Reviewed Original ResearchMulti-locus sequence typingMethicillin-susceptible Staphylococcus aureus (MSWhole-genome sequencingMethicillin-resistant Staphylococcus aureus (MRNeonatal intensive care unitSoft tissue infectionsStaphylococcus aureus,Intensive care unitMSSA isolatesMulti-locus sequence typing analysisWhole-genome sequence analysisTissue infectionsOutbreak-related strainsMupirocin-resistant isolatesCare unitNon-invasive respiratory supportTransmission eventsNeonatal faceInfection control measuresAssociated with infectionSequence typingMSSA infectionsRespiratory supportPredominant clusterInfectionThe Impact of Synergistic Therapy Between Colistin and Meropenem on Outcomes of People With Pneumonia or Bloodstream Infection Due to Carbapenem-Resistant Gram-Negative Pathogens
Huralska M, Pogue J, Rybak M, Abdul-Mutakabbir J, Stamper K, Marchaim D, Thamlikitkul V, Carmeli Y, Chiu C, Daikos G, Dhar S, Durante-Mangoni E, Gikas A, Kotanidou A, Paul M, Roilides E, Samarkos M, Sims M, Tancheva D, Tsiodras S, Kett D, Patel G, Calfee D, Leibovici L, Power L, Munoz-Price S, Shaikh H, Susick L, Latack K, Chiou C, Divine G, Ghazyaran V, Kaye K. The Impact of Synergistic Therapy Between Colistin and Meropenem on Outcomes of People With Pneumonia or Bloodstream Infection Due to Carbapenem-Resistant Gram-Negative Pathogens. Clinical Infectious Diseases 2025, 82: 391-398. PMID: 40682801, PMCID: PMC13016684, DOI: 10.1093/cid/ciaf398.Peer-Reviewed Original ResearchSynergistic combination therapyCarbapenem-resistant Gram-negative bacilliCombination therapyFunctional monotherapyA. baumanniiBloodstream infectionsClinical failureCarbapenem-resistant Gram-negative pathogensIn vitro synergy testingSynergistic therapyLast-line treatmentMicrobiological cure ratesAcinetobacter baumannii infectionsClinical failure rateGram-negative bacilliIn vitro synergyTime-kill analysisSynergistic combination treatmentGram-negative pathogensTreatment of pneumoniaColistin monotherapyColony-forming units/mlSynergy testBaumannii infectionsMicrobiological curePopulation Pharmacokinetic/Toxicodynamic Model for Polymyxin B in Critically Ill Patients to Identify the Risk of Nephrotoxicity
Hanafin P, Mahadevan R, Rao G, Zavascki A, Sandri A, Kwa A, Scheetz M, Kubin C, Shah J, Cherng B, Yin M, Wang J, Wang L, Calfee D, Bolon M, Purcell A, Nation R, Pogue J, Li J, Kaye K. Population Pharmacokinetic/Toxicodynamic Model for Polymyxin B in Critically Ill Patients to Identify the Risk of Nephrotoxicity. Clinical Pharmacology & Therapeutics 2025, 118: 841-852. PMID: 40524377, PMCID: PMC12353974, DOI: 10.1002/cpt.3729.Peer-Reviewed Original ResearchConceptsIntravenous polymyxin BSerum creatinineCritically ill patientsPolymyxin BResistant Gram-negative pathogensDose-limiting adverse effectsIll patientsCritically ill patient populationPolymyxin B dosingRisk of nephrotoxicityLast-line agentsPolymyxin B exposureIll patient populationGram-negative pathogensSensitive to polymyxin B.Clinically relevant treatmentIndirect response modelVancomycin useSupratherapeutic exposuresDrug exposureKidney injuryPatient populationPolymyxin B.Transit compartmentsObservational studyA discrete choice experiment to evaluate healthcare personnel preferences regarding risk-tailored policies for contact precautions for patients with methicillin-resistant Staphylococcus aureus
O’Hara L, Calfee D, Snyder G, Martin E, Angelino N, O’Hara N, Harris A. A discrete choice experiment to evaluate healthcare personnel preferences regarding risk-tailored policies for contact precautions for patients with methicillin-resistant Staphylococcus aureus. Infection Control And Hospital Epidemiology 2025, 46: 710-715. PMID: 40376809, DOI: 10.1017/ice.2025.65.Peer-Reviewed Original ResearchContact precautionsMethicillin-resistant Staphylococcus aureusPrevent MRSA transmissionProbability of uptakeChoice setsPreference policiesHealthcare personnelPolicy optionsMRSA carriageMRSA transmissionHigh-risk settingsPolicyRisk-tailored approachPolicy componentsAdvanced practice providersPatientsEnvironmental services personnelGown useCalculate utilitiesMRSAPractice providersPreferencesUtility scoresHigh-risk activitiesService personnelP-208. Does an electronic alert for secondary C. difficile prophylaxis result in vancomycin prophylaxis and reduction in recurrent CDI?
Singh H, Gouveia A, Ross B, Kuang D, wang S, Horowitz H, Simon M, Nelson B, Torres H, Kaplan S, Furuya E, Calfee D. P-208. Does an electronic alert for secondary C. difficile prophylaxis result in vancomycin prophylaxis and reduction in recurrent CDI? Open Forum Infectious Diseases 2025, 12: ofae631.412. PMCID: PMC11777948, DOI: 10.1093/ofid/ofae631.412.Peer-Reviewed Original ResearchBest practice alertRecurrent C. difficile infectionC. difficile infectionPrescription of broad-spectrum antibioticsClinical decision supportVancomycin prophylaxisBroad-spectrum antibioticsImmunized patientsEpisode of C. difficile infectionHistory of C. difficile infectionClinical decision support designEfficacy of VPElectronic health recordsManual chart reviewImmunocompromised patientsCDI recurrencePractice alertMedian ageRetrospective reviewElectronic alertsChart reviewHealth recordsFrequency of deathMedian daysHospitalized patientsP-1265. Risk Factors for Contamination of Healthcare Personnel Gloves and Gown with Candida auris (C. auris)
Harris A, Sansom S, Hayden M, Calfee D, Huang S, Bahr-Robertson M, Newman M, Singh R, Saavedra R, umana U, O’Hara L. P-1265. Risk Factors for Contamination of Healthcare Personnel Gloves and Gown with Candida auris (C. auris). Open Forum Infectious Diseases 2025, 12: ofae631.1447. PMCID: PMC11778459, DOI: 10.1093/ofid/ofae631.1447.Peer-Reviewed Original ResearchC. aurisHealthcare personnelMultiple body sitesHigh risk of transmissionHigh riskPatient's axillaHospitalized patientsRisk of transmissionHospital transmissionBody sitesTransmission of C. aurisConduction studiesRisk factorsPatient care techniciansAntiseptic productsStandardized data collection formEnvironmental surfacesData collection formCandida aurisEnvironmental risk factorsGown contaminationCare activitiesCare tasksRespiratory therapistsHealthcare settingsP-332. A Discrete Choice Experiment to Evaluate Healthcare Personnel Preferences Regarding Risk-Tailored Policies for Contact Precautions for Patients with Methicillin-Resistant Staphylococcus aureus in Hospitals
O’Hara L, Calfee D, Angelino N, Harris A, Snyder G, Martin E, O’Hara N. P-332. A Discrete Choice Experiment to Evaluate Healthcare Personnel Preferences Regarding Risk-Tailored Policies for Contact Precautions for Patients with Methicillin-Resistant Staphylococcus aureus in Hospitals. Open Forum Infectious Diseases 2025, 12: ofae631.535. PMCID: PMC11779223, DOI: 10.1093/ofid/ofae631.535.Peer-Reviewed Original ResearchEnvironmental servicesPolicy optionsAdvanced practice providersChoice experiment surveyDiscrete choice experimentHealthcare personnelMixed logit modelPractice providersDiscrete choice surveyProbability of uptakeChoice setsChoice experimentRespondent's occupationLogit modelChoice surveyContact precautionsRisk-tailored approachPolicyMRSA transmissionExperiences SurveyPolicy componentsPhysical therapistsCare activitiesRespiratory therapistsRisk of MRSA transmission
2024
Investigation and control of an outbreak of methicillin-susceptible Staphylococcus aureus skin and soft tissue infections in a level IV NICU
Rivera G, Mitchell K, Marino J, Yap V, Senaldi L, Tiwari P, Cannon J, Roldon R, Rowlinson M, Haas W, Hemway R, Calfee D, Saiman L, Westblade L, Acker K. Investigation and control of an outbreak of methicillin-susceptible Staphylococcus aureus skin and soft tissue infections in a level IV NICU. Antimicrobial Stewardship & Healthcare Epidemiology 2024, 4: s27-s27. PMCID: PMC11504376, DOI: 10.1017/ash.2024.133.Peer-Reviewed Original ResearchMulti-locus sequence typingWhole-genome sequencingNeonatal intensive care unitMupirocin-resistant strainsSoft tissue infectionsMupirocin resistanceMSSA colonizationWhole-genome sequence analysisCase-patientsMolecular typingMethicillin-resistant S. aureusSoft-tissue infection casesAntibiotic susceptibility testingTissue infectionsStaphylococcal scalded skin syndromeNon-invasive respiratory supportGenome sequenceMupA geneIsolate relatednessMLST typesSequence typingMutational eventsSusceptibility testingFisher's exact testWilcoxon rank sum testHealthcare personnel opinions regarding the feasibility of a risk-tailored approach to contact precautions for methicillin-resistant Staphylococcus aureus in the acute care setting
O’Hara L, Harris A, Calfee D, Snyder G, Cottam J, O’Hara N, Martin E. Healthcare personnel opinions regarding the feasibility of a risk-tailored approach to contact precautions for methicillin-resistant Staphylococcus aureus in the acute care setting. Infection Control And Hospital Epidemiology 2024, 45: 900-902. PMID: 38646712, DOI: 10.1017/ice.2024.54.Peer-Reviewed Original Research